DYSTHYMIC DISORDER IN YOUTH

描述（改编自申请人的摘要）：本申请的目的是 指导临床科学家发展奖（MCSDA-K 08）赠款是允许 申请人开发一个研究计划，在恶劣心境的研究 儿童和青少年的疾病，并发展必要的技能， 测试该年龄组的心境恶劣的假设是：1）a 神经生物学介导的情绪障碍， 精神药理学干预，和2）家族性疾病，其中风险 导致这种疾病发展的因素至少部分是遗传性的 传来 在几位研究人员的工作基础上， 成年人的慢性抑郁症，并利用这些研究人员中的一些人， 成人精神病学作为导师和顾问的主要研究者， 该计划将评估心境恶劣分类的有效性 使用受试者的临床样本的作为心境障碍的青年障碍 招募到一个治疗方案中 使用方法学的研究 这有助于理解成年人的疾病 被提议。 在此期间进行的核心研究 Grant是一项安慰剂对照、双盲的氟西汀疗效研究， 儿童和青少年心境恶劣障碍的短期治疗。 所述项目还将制定一个系统的方法来研究 儿童和青少年对慢性抑郁症的熟悉程度， 在对儿童期先证者的对照家庭研究中， 与对照比较。 初步研究调查的作用 分子遗传学研究有助于理解 病因的障碍也提出了建议。 主要研究者， 完成临床培训和初步研究培训后， 追求致力于临床研究的职业生涯，并建议在 遗传流行病学和分子遗传学的研究技术， 加强其今后在慢性病领域进行研究的能力的手段 儿童和青少年的情绪障碍。 一个系统的程序 教学式教育，辅以实验室经验， 监督和独立研究项目，提出。 MCSDA将 为主要研究者提供更多的研究经验 儿童和青少年的慢性情绪障碍，并促进他的成长 进行独立的临床研究

DESCRIPTION (Adapted from Applicant's Abstract): The purpose of this Mentored Clinical Scientist Development Award (MCSDA-K08) grant is to allow the applicant to develop a research program in the study of Dysthymic Disorder in children and adolescents and to develop the skills necessary to test the hypotheses that dysthymia in this age group is: 1) a neurobiologically mediated mood disorder that is amenable to psychopharmacologic intervention, and 2) a familial disorder in which risk factors for the development of the disorder are at least in part genetically transmitted. Building on the work of several investigators who have studied chronic depression in adults, and using several of these researchers in adult psychiatry as mentors and consultants to the Principal Investigator, this program will assess the validity of the classification of Dysthymic Disorder in youth as a mood disorder using clinical samples of subjects recruited into a treatment protocol. Research studies using methodologies that have contributed to the understanding of the disorder in adult subjects are proposed. The core study to be conducted during the period of this grant is a placebo-controlled, double-blind efficacy study of Fluoxetine in the short-term treatment of Dysthymic Disorder in children and adolescents. The project described will also develop a systematic approach to studying the familiarity of chronic depression in children and adolescents, culminating in controlled family studies of pediatric-age probands in comparison to controls. Preliminary studies investigating the role of Molecular Genetics studies in contributing to the understanding of the etiology of the disorder are also proposed. The Principal Investigator, having completed clinical training and preliminary research training, is pursuing a career devoted to clinical research and, proposes to train in the research techniques of Genetic Epidemiology and Molecular Genetics as a means of enhancing its capacity to conduct future research in the chronic mood disorders of childhood and adolescence. A program of systematic didactic education, supplemented by laboratory experience, mentored supervision and independent research projects, is proposed. This MCSDA will provide the Principal Investigator with further experience in the study of chronic mood disorders in children and adolescents and foster his growth toward conducting independent clinical research.