DYSTHYMIC DISORDER IN YOUTH

描述(改编自申请者摘要)：目的 导师临床科学家发展奖(MCSDA-K08)授予 申请开发恶劣心境研究项目的申请者 儿童和青少年的精神障碍和发展必要的技能 测试这个年龄段的恶劣心境是：1) 神经生物介导性情绪障碍 精神药理学干预，以及2)有风险的家庭障碍 导致这种疾病的因素至少有一部分是遗传的。 已发送。以几名研究人员的工作为基础 成年人的慢性抑郁症，并利用其中几名研究人员在 成人精神病学作为首席调查员的导师和顾问， 本节目将评估恶劣心境分类的有效性 青少年精神障碍作为一种情绪障碍的临床研究 被招募到治疗方案中。使用方法学的研究性研究 有助于理解成人受试者的精神障碍 都被提出了。在此期间将进行的核心研究 GRANT是一项氟西汀的安慰剂对照双盲疗效研究 儿童和青少年恶劣心境障碍的短期治疗。 所描述的项目还将开发一种系统的方法来研究 儿童和青少年对慢性抑郁症的熟悉程度， 年对儿童年龄先证者的对照家庭研究达到顶峰 与控件进行比较。初步研究调查的作用 分子遗传学研究有助于理解 文中还提出了该病的病因。首席调查员， 已完成临床培训和初步研究培训，IS 致力于临床研究的职业生涯，并计划在 遗传流行病学和分子遗传学的研究技术 加强其在慢性疾病领域开展未来研究的能力的手段 儿童和青春期的情绪障碍。一项系统化的计划 讲授教育，辅以实验室经验，指导 提出了督导和自主研究项目。这个MCSDA将 为首席调查员提供进一步研究的经验 儿童和青少年的慢性情绪障碍并促进其成长 进行独立的临床研究。

DESCRIPTION (Adapted from Applicant's Abstract): The purpose of this Mentored Clinical Scientist Development Award (MCSDA-K08) grant is to allow the applicant to develop a research program in the study of Dysthymic Disorder in children and adolescents and to develop the skills necessary to test the hypotheses that dysthymia in this age group is: 1) a neurobiologically mediated mood disorder that is amenable to psychopharmacologic intervention, and 2) a familial disorder in which risk factors for the development of the disorder are at least in part genetically transmitted. Building on the work of several investigators who have studied chronic depression in adults, and using several of these researchers in adult psychiatry as mentors and consultants to the Principal Investigator, this program will assess the validity of the classification of Dysthymic Disorder in youth as a mood disorder using clinical samples of subjects recruited into a treatment protocol. Research studies using methodologies that have contributed to the understanding of the disorder in adult subjects are proposed. The core study to be conducted during the period of this grant is a placebo-controlled, double-blind efficacy study of Fluoxetine in the short-term treatment of Dysthymic Disorder in children and adolescents. The project described will also develop a systematic approach to studying the familiarity of chronic depression in children and adolescents, culminating in controlled family studies of pediatric-age probands in comparison to controls. Preliminary studies investigating the role of Molecular Genetics studies in contributing to the understanding of the etiology of the disorder are also proposed. The Principal Investigator, having completed clinical training and preliminary research training, is pursuing a career devoted to clinical research and, proposes to train in the research techniques of Genetic Epidemiology and Molecular Genetics as a means of enhancing its capacity to conduct future research in the chronic mood disorders of childhood and adolescence. A program of systematic didactic education, supplemented by laboratory experience, mentored supervision and independent research projects, is proposed. This MCSDA will provide the Principal Investigator with further experience in the study of chronic mood disorders in children and adolescents and foster his growth toward conducting independent clinical research.