Formation of boundaries in the developing embryo

发育中胚胎边界的形成

• 批准号: DP190102771
• 负责人: A/Prof Mirana Ramialison
• 金额: $ 26.4万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-10 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102771
• 关键词: Formation; boundaries; developing; embryo

This project aims to decipher how the boundaries between the different organs are established in the developing embryo. The project aims to identify the components of the gene regulatory network that controls lateral plate mesoderm formation, develop a mathematical model that can explain how the domains are formed within this region, and validate novel interactions in vivo in zebrafish. The expected outcome of the project is to reveal how the progenitors of our body parts are instructed to be positioned at the right time and at the right place in the embryo. This project should provide significant benefit such as the expansion of Australia's knowledge base and research capability in cross-disciplinary science.

该项目旨在破译不同器官之间的界限是如何在发育中的胚胎中建立的。该项目旨在确定控制侧板中胚层形成的基因调控网络的组成部分，开发一个数学模型，可以解释该区域内的结构域是如何形成的，并验证斑马鱼体内的新型相互作用。该项目的预期成果是揭示我们身体部位的祖细胞是如何被指示在胚胎中的正确时间和正确位置定位的。该项目将带来巨大的好处，如扩大澳大利亚的知识基础和跨学科科学的研究能力。