Old genes learning new tricks: characterising regulatory changes driving increased heart complexity during vertebrate evolution

老基因学习新技巧：表征脊椎动物进化过程中导致心脏复杂性增加的调控变化

• 批准号: DP140101067
• 负责人: A/Prof Mirana Ramialison
• 金额: $ 27.23万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-02-17 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140101067
• 关键词: Old; genes; learning; new; tricks

The heart has dramatically increased in morphological complexity during vertebrate evolution but the molecular basis driving these major changes remains unknown. Using comparative genomics approaches, this project will explore changes in the regulation of genes involved in heart formation that lead to changes in cardiac structure. It will elucidate for the first time the cardiac regulatory repertoire in zebrafish and will compare it with that of fly and mouse using cutting-edge bioinformatics pipelines. This work will unravel cardiac-specific regulatory modifications that give rise to evolutionary changes. On a broader scale, it will shed new light on the role of regulatory innovations over gene innovations in the emergence of new traits.

在脊椎动物进化过程中，心脏的形态复杂性急剧增加，但驱动这些主要变化的分子基础仍然未知。使用比较基因组学方法，该项目将探索心脏形成相关基因调控的变化，从而导致心脏结构的变化。它将首次阐明斑马鱼的心脏调节功能，并将使用尖端的生物信息学管道将其与苍蝇和小鼠进行比较。这项工作将解开导致进化变化的心脏特异性调节修饰。在更广泛的范围内，它将揭示新性状出现中调控创新对基因创新的作用。