ANGII NEURAL INTERACTIONS IN CARDIOVASCULAR CONTROL

心血管控制中的 ANGII 神经相互作用

• 批准号: 2695269
• 负责人: JOHN P COLLISTER
• 金额: $ 7.78万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2695269
• 关键词: angiotensin /renin /aldosterone hypertension; angiotensin II; area postrema; autonomic reflex; laboratory rat; nutrition related tag; renin angiotensin system; salt intake; vasomotion

DESCRIPTION (Adapted from applicant's abstract) This application is based on the hypothesis that changes in salt intake lead to changes in circulating levels of the hormone, angiotensin II (AII). Subsequent alterations in AII levels act via the brainstein site known as the area postrema to create neurogenic changes in medullary sympathetic activity. More specifically, an increase in salt intake will decrease circulating levels of AII via suppression of the renin-angiotensin system (RAS). Decreased concentrations of AII at the area postrema will cause a withdrawal of sympathetic tone to the kidneys and vasculature. Suppression of the RAS along with withdrawal of sympathetic tone allows for the preservation of arterial pressure, as well as sodium and volume homeostasis. It is hypothesized that any intervention in this NaCl-AII- Sympathetic Reflex (during increases in NaCl intake) will result in a lack of salt induced sympathoinhibition and salt induced hypertension. Dr. John Collister received his D.V.M. in 1994 from the Univ. of IL. He is now currently working toward a Ph.D. in the Dept. of Vet. PathoBiology at the Univ. of MN. The applicant has both a strong academic and research background. He has chosen a research career in the biomedical sciences of integrated cardiovascular physiology. During the initial two years of support from this award, Dr. Collister will be under the direct supervision of the sponsor, Dr. John Osborn. During this time, 100% effort will be placed on the proposed research while the candidate completes his Ph.D. thesis. Dr. Osborn has trained successful scientists in the past and is a well known and respected scientist both locally and nationally, in the field of hypertension research. Upon completion of his Ph.D., Dr. Collister will be appointed to an Assistant Professorship within the Dept. of Vet. PathoBiology. At this time, 80% effort will be placed on the proposed research, while other time will be utilized teaching classes within the College of Veterinary Medicine (Anatomy and Physiology). In addition, the advisory committee will meet regularly to discuss research data and future directions. This committee is made up of diverse individuals who are all active and trained researchers in specific areas of the RAS. Dr. Collister will also have the opportunity to interact with individuals from the Departments of Pharmacology, Neuroscience, and Cellular and Integrative Physiology, through attending regular journal clubs and seminars. Upon completion, Dr. Collister will have fully developed into an independent investigator.

描述(改编自申请人的摘要)本申请是 基于这样的假设，即盐摄入量的变化会导致 循环中的荷尔蒙血管紧张素II(AII)水平。后续 所有水平的变化都是通过被称为脑区的大脑部位起作用的 在延髓交感神经活动中产生神经源性变化。 更具体地说，盐摄入量的增加会减少血液循环。 通过抑制肾素-血管紧张素系统(RAS)升高AII水平。 后遗症区域内AII浓度的降低将导致 交感神经张力对肾脏和血管系统的收缩。 抑制RAS和撤销交感神经音调允许 用于维持动脉压、钠和血容量 动态平衡。假设任何对氯化钠-所有-的干预- 交感神经反射(在食盐摄入量增加期间)将导致 缺盐引起交感神经抑制和盐源性高血压。 约翰·科利斯特博士于1994年从大学获得医学博士学位。是IL的。 他目前正在攻读该系的博士学位。兽医。 大学的病理生物学。MN.申请者既有很强的 学术和研究背景。他选择了一项研究事业， 综合心血管生理学的生物医学科学。在.期间 这一奖项的最初两年支持，科利斯特博士将是 在赞助商约翰·奥斯本博士的直接监督下。在.期间 这一次，100%的精力将放在拟议的研究上，而 候选人完成他的博士论文。奥斯本博士成功地训练了 是过去的科学家，也是一位著名和受人尊敬的科学家 在地方和国家，在高血压研究领域。vt.在.的基础上 完成博士学位后，科利斯特博士将被任命为助理 系内教授职称。兽医。病理生物学。此时，80% 将把精力放在拟议的研究上，而其他时间将 利用兽医学院内的课堂教学 (解剖学和生理学)此外，咨询委员会将举行会议。 定期讨论研究数据和未来方向。这 委员会由不同的人组成，他们都很活跃， 在RAS的特定领域培训研究人员。科利斯特博士将 也有机会与来自 药理学、神经科学系、细胞与综合系 生理学，通过参加定期的杂志俱乐部和研讨会。vt.在.的基础上 完成后，科利斯特博士将完全发展成为一名独立的 调查员。