ANGII NEURAL INTERACTIONS IN CARDIOVASCULAR CONTROL

心血管控制中的 ANGII 神经相互作用

• 批准号: 6182753
• 负责人: JOHN P COLLISTER
• 金额: $ 10.05万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6182753
• 关键词: angiotensin /renin /aldosterone hypertension; angiotensin II; area postrema; autonomic reflex; laboratory rat; nutrition related tag; renin angiotensin system; salt intake; vasomotion

DESCRIPTION (Adapted from applicant's abstract) This application is based on the hypothesis that changes in salt intake lead to changes in circulating levels of the hormone, angiotensin II (AII). Subsequent alterations in AII levels act via the brainstein site known as the area postrema to create neurogenic changes in medullary sympathetic activity. More specifically, an increase in salt intake will decrease circulating levels of AII via suppression of the renin-angiotensin system (RAS). Decreased concentrations of AII at the area postrema will cause a withdrawal of sympathetic tone to the kidneys and vasculature. Suppression of the RAS along with withdrawal of sympathetic tone allows for the preservation of arterial pressure, as well as sodium and volume homeostasis. It is hypothesized that any intervention in this NaCl-AII- Sympathetic Reflex (during increases in NaCl intake) will result in a lack of salt induced sympathoinhibition and salt induced hypertension. Dr. John Collister received his D.V.M. in 1994 from the Univ. of IL. He is now currently working toward a Ph.D. in the Dept. of Vet. PathoBiology at the Univ. of MN. The applicant has both a strong academic and research background. He has chosen a research career in the biomedical sciences of integrated cardiovascular physiology. During the initial two years of support from this award, Dr. Collister will be under the direct supervision of the sponsor, Dr. John Osborn. During this time, 100% effort will be placed on the proposed research while the candidate completes his Ph.D. thesis. Dr. Osborn has trained successful scientists in the past and is a well known and respected scientist both locally and nationally, in the field of hypertension research. Upon completion of his Ph.D., Dr. Collister will be appointed to an Assistant Professorship within the Dept. of Vet. PathoBiology. At this time, 80% effort will be placed on the proposed research, while other time will be utilized teaching classes within the College of Veterinary Medicine (Anatomy and Physiology). In addition, the advisory committee will meet regularly to discuss research data and future directions. This committee is made up of diverse individuals who are all active and trained researchers in specific areas of the RAS. Dr. Collister will also have the opportunity to interact with individuals from the Departments of Pharmacology, Neuroscience, and Cellular and Integrative Physiology, through attending regular journal clubs and seminars. Upon completion, Dr. Collister will have fully developed into an independent investigator.

描述（改编自申请人的摘要）该申请是 基于这样的假设：盐摄入量的变化会导致 激素血管紧张素 II (AII) 的循环水平。 随后的 AII 水平的改变通过称为脑斯坦区域的脑斯坦部位起作用 postrema 在髓质交感神经活动中产生神经源性变化。 更具体地说，盐摄入量的增加会减少循环 通过抑制肾素-血管紧张素系统（RAS）来降低 AII 水平。 后区 AII 浓度降低将导致 肾脏和脉管系统的交感神经张力减弱。 抑制 RAS 并减弱交感神经张力可以 用于保存动脉压以及钠和容量 体内平衡。 据推测，对这种 NaCl-AII- 的任何干预 交感神经反射（在氯化钠摄入量增加期间）将导致 缺乏盐引起的交感神经抑制和盐引起的高血压。 约翰·科利斯特 (John Collister) 博士获得了 D.V.M. 1994年从大学毕业。 伊利诺伊州。 他目前正在攻读博士学位。在兽医部门。 大学病理生物学。 明尼苏达州。 申请人既有较强的 学术和研究背景。 他选择了研究职业 综合心血管生理学的生物医学科学。 期间 在该奖项的最初两年的支持下，科利斯特博士将 在申办者约翰·奥斯本博士的直接监督下。 期间 这次，我们将把100%的精力放在所提出的研究上，同时 候选人完成博士学位。论文。 奥斯本博士训练成功 过去的科学家，并且是一位著名且受人尊敬的科学家 当地和全国的高血压研究领域。 之上 完成博士学位后，科利斯特博士将被任命为助理 兽医系教授职位。病理生物学。 此时，80% 将把精力放在拟议的研究上，而其他时间将 在兽医学院内使用教学课程 （解剖学和生理学）。 此外，咨询委员会将召开会议 定期讨论研究数据和未来方向。 这 委员会由不同的个人组成，他们都很活跃并且 RAS 特定领域受过培训的研究人员。 科利斯特博士将 也有机会与来自各行各业的人士互动 药理学、神经科学、细胞与综合系 生理学，通​​过参加定期的期刊俱乐部和研讨会。 之上 完成后，科利斯特博士将完全发展成为一名独立的 研究者。