ANGII NEURAL INTERACTIONS IN CARDIOVASCULAR CONTROL

心血管控制中的 ANGII 神经相互作用

• 批准号: 6388436
• 负责人: JOHN P COLLISTER
• 金额: $ 11.89万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6388436
• 关键词: angiotensin /renin /aldosterone hypertension; angiotensin II; area postrema; autonomic reflex; laboratory rat; nutrition related tag; renin angiotensin system; salt intake; vasomotion

DESCRIPTION (Adapted from applicant's abstract) This application is based on the hypothesis that changes in salt intake lead to changes in circulating levels of the hormone, angiotensin II (AII). Subsequent alterations in AII levels act via the brainstein site known as the area postrema to create neurogenic changes in medullary sympathetic activity. More specifically, an increase in salt intake will decrease circulating levels of AII via suppression of the renin-angiotensin system (RAS). Decreased concentrations of AII at the area postrema will cause a withdrawal of sympathetic tone to the kidneys and vasculature. Suppression of the RAS along with withdrawal of sympathetic tone allows for the preservation of arterial pressure, as well as sodium and volume homeostasis. It is hypothesized that any intervention in this NaCl-AII- Sympathetic Reflex (during increases in NaCl intake) will result in a lack of salt induced sympathoinhibition and salt induced hypertension. Dr. John Collister received his D.V.M. in 1994 from the Univ. of IL. He is now currently working toward a Ph.D. in the Dept. of Vet. PathoBiology at the Univ. of MN. The applicant has both a strong academic and research background. He has chosen a research career in the biomedical sciences of integrated cardiovascular physiology. During the initial two years of support from this award, Dr. Collister will be under the direct supervision of the sponsor, Dr. John Osborn. During this time, 100% effort will be placed on the proposed research while the candidate completes his Ph.D. thesis. Dr. Osborn has trained successful scientists in the past and is a well known and respected scientist both locally and nationally, in the field of hypertension research. Upon completion of his Ph.D., Dr. Collister will be appointed to an Assistant Professorship within the Dept. of Vet. PathoBiology. At this time, 80% effort will be placed on the proposed research, while other time will be utilized teaching classes within the College of Veterinary Medicine (Anatomy and Physiology). In addition, the advisory committee will meet regularly to discuss research data and future directions. This committee is made up of diverse individuals who are all active and trained researchers in specific areas of the RAS. Dr. Collister will also have the opportunity to interact with individuals from the Departments of Pharmacology, Neuroscience, and Cellular and Integrative Physiology, through attending regular journal clubs and seminars. Upon completion, Dr. Collister will have fully developed into an independent investigator.

描述（改编自申请人摘要）本申请是 基于盐摄入量的变化会导致 循环水平的激素，血管紧张素II（AII）。 后续 所有水平的改变都是通过大脑中被称为 postrema，以在延髓交感神经活动中产生神经源性变化。 更具体地说，盐摄入量的增加会减少循环 通过抑制肾素-血管紧张素系统（RAS）降低AII水平。 最后区AII浓度降低将导致 交感神经紧张度下降至肾脏和脉管系统。 RAS的抑制沿着交感神经紧张的消退， 用于保持动脉压、钠和容量 体内平衡 据推测，任何干预这种氯化钠-铝- 交感神经反射（在NaCl摄入量增加期间）将导致 缺盐引起的交感神经抑制和盐性高血压。 博士John Collister收到了他的D.V.M. 1994年，从伊利诺伊大学毕业。 他目前正在攻读博士学位。在部门。兽医 病理生物学在明尼苏达大学。 申请人既有很强的 学术和研究背景。 他选择了一个研究生涯， 综合心血管生理学的生物医学科学。 期间 在最初两年的支持，从这个奖项，博士科利斯特将 在赞助商约翰奥斯本博士的直接监督下进行 期间 这一次，100%的努力将放在拟议的研究，而 候选人完成博士学位。论文 奥斯本博士训练成功 科学家在过去，是一个众所周知的和受人尊敬的科学家， 在高血压研究领域， 后 完成博士学位，Collister博士将被任命为助理 系内教授 兽医病理生物学 目前，80% 将把精力放在拟议的研究上，而其他时间将 在兽医学院的教学课程中使用 （解剖学和生理学）。 此外，咨询委员会将举行会议， 定期讨论研究数据和未来方向。 这 委员会由各种各样的人组成，他们都是活跃的， 在RAS的特定领域培训研究人员。 科里斯特医生会 也有机会与个人互动， 药理学系、神经科学系、细胞与综合系 生理学，通过参加定期的期刊俱乐部和研讨会。 后 完成后，博士Collister将完全发展成为一个独立的 调查员