SUPPLY, EVALUATION AND SELECTION OF LIVING RENAL DONORS

活体肾捐献者的供应、评估和选择

• 批准号: 2733836
• 负责人: Akinlolu Oluseun Ojo
• 金额: $ 11.29万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2733836
• 关键词: behavior prediction; behavioral /social science research tag; blood groups; chronic renal failure; clinical research; culture; decision making; family sizes; human population study; human subject; interview; kidney transplantation; outcomes research; population survey; serology /serodiagnosis; socioeconomics; statistics /biometry; tissue donors

Over 30,000 end-stage renal disease (ESRD) patients are waiting for cadaveric kidney transplantation. This number is expected to double in five years. In the last decease, the number of kidneys from cadaver donors has remained stagnant at 7,500-8,000/year. Although living renal donation is accepted as a low risk procedure with superior allograft survival, only 25% of transplants performed in European Americans and 10% of transplants in African americans are from living donors. factors governing the supply of living renal donors are not well understood. Despite well-established criteria for donor nephrectomy, variable which influence the outcomes of donor evaluation/selection process have not been rigorously studied. The goals of this project are to: (I) identify and describe the obstacles to the supply of living renal donors; (ii) identify the medical diagnoses, laboratory findings and non-medical factors which impact the outcomes of donor selection/evaluation process and ; (iii) analyze the relationships between the predictors of living renal donation and the characteristics of various ESRD populations. A quasi-experimental design with statistical adjustment for baseline characteristics will be applied. the sampling frame is a consecutive sample of three cohorts (transplant candidates, evaluable and unevaluable potential donors) from two transplants centers (University of Michigan and Henry Ford Hospitals). Clinical and laboratory investigations and multi-stage, longitudinal, interviewer-administered, validated survey instruments will be prospectively applied to 840 transplant candidates and 420 potential donors. Descriptive and multi variate techniques will be used to analyze the relationships between the probability of being a donor and 3 classes of explanatory variables: (1) demographics, cultural beliefs and socioeconomic characteristics; (2) medical diagnoses and serologies; and (3) ABO blood groups and positive crossmatch. The relationship between familial size and the pool of potential living donors will also be analyzed. A cohort of donors will be prospectively followed for overall health and renal outcomes. The proposed project will yield additional information needed to build effective public health campaigns to improve living donor awareness, increase the donor pool and bring the benefit of kidney transplantation to more ESRD patients, particularly the minority patients, among whom access to transplantation is an even greater problem. The prospective donor database will demonstrate the feasibility of a multi- center living renal donor registry which is essential to future research in living renal donation.

超过30,000名终末期肾病(ESRD)患者正在等待 身体肾移植。这一数字预计将翻一番 五年后。在上一次死亡中，身体上的肾脏数量 捐助者仍然停滞不前，每年7500至8000人。虽然活着 肾脏捐献被认为是一种低风险的程序 同种异体移植物存活，只有25%的移植手术在欧洲进行 美国人和10%的非裔美国人的移植来自 活着的捐赠者。影响活体肾脏捐赠者供应的因素有 不是很清楚。尽管捐赠者的标准已经确立 影响供者结局的变量--肾切除术 评估/选择过程没有得到严格的研究。这个 该项目的目标是：(1)查明和描述 活体肾脏捐赠者的供应；(2)确定医疗诊断； 影响预后的实验室检查结果和非医学因素 捐助者选择/评价过程；(3)分析 活体肾捐献预测因素与年龄的关系 各种ESRD人群的特征。一种准实验 对基线特征进行统计调整的设计将是 已申请。抽样帧是三个队列的连续样本 (移植候选人、可评估和不可评估的潜在捐赠者) 来自两个移植中心(密歇根大学和亨利·福特 医院)。临床和实验室检查和多阶段， 面试者管理的经验证的纵向调查工具 将前瞻性地应用于840名移植候选人和420名 潜在的捐赠者。将使用描述性和多变量技术 分析成为捐献者的概率与 和三类解释变量：(1)人口统计、文化 信仰和社会经济特征；(2)医学诊断和 血清学；(3)ABO血型和阳性交叉配型。这个 家庭规模与潜在生活池的关系 捐赠者也将被分析。一批捐赠者将是 对总体健康和肾脏结果进行前瞻性跟踪。这个 拟议的项目将产生建立所需的额外信息 开展有效的公共卫生运动，提高对活体捐赠者的认识； 增加供体库，为肾移植带来好处 对更多终末期肾病患者，特别是少数族裔患者， 谁能获得移植是一个更大的问题。这个 潜在捐赠者数据库将证明多个 中心活体肾脏捐赠者登记对未来的研究至关重要 活体肾脏捐献。