UROKINASE--A LINK BETWEEN CELL ADHESION AND PROTEOLYSIS
UROKINASE--A LINK BETWEEN CELL ADHESION AND PROTEOLYSIS
批准号:
2734932
负责人:
DAVID A WALTZ
金额:
$8.37万
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-07-01 至 1999-06-30
关键词:
cell adhesion cell migration crosslink drug receptors enzyme linked immunosorbent assay monocyte plasminogen activator plasminogen activator inhibitors polymerase chain reaction protein sequence proteolysis receptor binding receptor expression tissue /cell culture urokinase vitronectin western blottings
中文摘要
该研究提案是一个多方面的项目和细胞迁移。
细胞相关蛋白分解中对细胞重要的中心成分
尿激酶型纤溶酶原激活剂及其细胞表面迁移与组织重塑
受体。我们之前已经证明了它的粘附性
单核细胞依赖于uPA受体的占位并被调节
纤溶酶原激活物抑制物-1(PAI-1)
通过uPA/PAI复合体周转。我们最近描述了一部小说
Vitronectin受体的活性与uPA受体的占有率有关。
由于Vitronectin的一个已知功能是结合PAI-1,我们假设
UPA诱导的Vitronectin结合启动细胞附着,并通过
增强uPA/PAI-1复合体的形成调节uPA依赖
蛋白质分解并启动随后的细胞分离。为了测试这一点
假设我们将确定Vitronectin受体的特征并确定
尿激酶型纤溶酶原激活剂诱导的玻璃连结蛋白与细胞周膜结合的重要性
蛋白质分解和细胞迁移。
英文摘要
The research proposal is a multifaceted project and cellular migration.
Central elements in cell-associated proteolysis important to cell
migration and tissue remodeling are urokinase (uPA) and its cell-surface
receptor. We have previously demonstrated that the adhesiveness of
monocytic cells is dependent upon uPA receptor occupancy and regulated
by the uPA inhibitor plasminogen activator inhibitor type 1 (PAI-1)
through uPA/PAI complex turnover. We have recently described a novel
vitronectin receptor whose activity is coupled to uPA receptor occupancy.
As a known function of vitronectin is to bind PAI-1, we hypothesize that
uPA-induced vitronectin binding initiates cellular attachment and by
potentiating uPA/PAI-1 complex formation regulates uPA-dependent
proteolysis and initiates subsequent cell detachment. To test this
hypothesis we will characterize the vitronectin receptor and determine
the importance of uPA-induced vitronectin binding on pericellular
proteolysis and cellular migration.
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会议论文
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UROKINASE--A LINK BETWEEN CELL ADHESION AND PROTEOLYSIS
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批准号:2445010
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项目类别:
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资助金额:$8.37万
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财政年份:1994
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负责人:DAVID A WALTZ
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依托单位:
UROKINASE--A LINK BETWEEN CELL ADHESION AND PROTEOLYSIS
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批准号:2211262
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项目类别:
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资助金额:$8.26万
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UROKINASE--A LINK BETWEEN CELL ADHESION AND PROTEOLYSIS
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批准号:2211261
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资助金额:$8.26万
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UROKINASE--A LINK BETWEEN CELL ADHESION AND PROTEOLYSIS
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批准号:2211260
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项目类别:
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资助金额:$8.37万
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财政年份:1994
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负责人:DAVID A WALTZ
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依托单位:
海外基金