TYPE V COLLAGEN AND CORNEAL STROMA
V 型胶原蛋白和角膜基质
基本信息
- 批准号:2502428
- 负责人:
- 金额:$ 17.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-12-01 至 2000-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: The matrix composition of the cornea is critical to its
function as a transparent barrier in the visual pathway. In addition to
collagen type I, the major corneal collagen, up to 20 percent of the
collagen of the cornea is composed of collage V, a minor constituent in
other tissues. This project tests the hypothesis that type V collagen
regulates corneal organization, specifically, the assembly and diameter of
heterotypic collagen I/V fibrils. It employs the pN/pN mouse which carries
a targeted mutation in collagen a2(V). Previous esults showing abnormal
corneal stroma development in both homozygote and heterozygote mutants are
consistent with this hypothesis.
The Specific Aims are to test the following predictions of the hypothesis:
1. The diameter of corneal collagen fibrils depends upon the inclusion or
exclusion of type V collagen in heterotypic fibrils of the cornea. 2. A
mutation of collagen V alters its transit through the synthetic and
secretory pathway. 3. Collagen V and Collagen I/V heterotype fibrils bind
to keratocyte cell surface receptors in ligand specific fashions. 4.
Mutant type V collagen alters the functional integrity of the corneal
stroma.
The proposed experiments will provide fundamental information about the
cellular mechanisms of cell/matrix interaction and about the role of type V
collagen in corneal stroma development and in remodeling such as occurs
during wound healing.
角膜基质的组成对其形成至关重要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SANDRA K MASUR其他文献
SANDRA K MASUR的其他文献
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{{ truncateString('SANDRA K MASUR', 18)}}的其他基金
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