HERITAGE--GENETICS, RESPONSE TO EXERCISE, RISK FACTORS

遗传——遗传学、运动反应、风险因素

• 批准号: 2771289
• 负责人: CLAUDE BOUCHARD
• 金额: $ 71.21万
• 依托单位: LAVAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2771289
• 关键词: aerobic exercise; age difference; blood chemistry; blood pressure; body composition; cardiovascular disorder epidemiology; cardiovascular stress test; clinical research; diabetes mellitus genetics; disease /disorder proneness /risk; enzyme activity; family genetics; genetic markers; glucose tolerance test; human data; human tissue; linkage mapping; noninsulin dependent diabetes mellitus; phenotype; racial /ethnic difference

The aim of the HERITAGE Family Study is to document cardiovascular and metabolic responses to endurance exercise training, and the contribution of genetic factors to the concomitant response of cardiovascular disease (CVD) and diabetes (NIDDM) risk factors. A consortium of 5 universities is conducting the study. In Phase 1 (1992- 1997), about 765 sedentary subjects were exercise-trained with the same program for 20 weeks. There will be in the final master file about 495 individuals from 98 families of Caucasian descent with both parents and biological adult offspring and 270 individuals from 102 black families. Before and after training, maximal oxygen uptake and cardiovascular and metabolic responses to submaximal and maximal exercise were measured. Plasma lipids, lipoproteins, apolipoproteins and enzymes, insulin and glucose response to an intravenous glucose load, plasma sex steroids and glucocorticoids, resting and exercise blood pressures, and body fat, regional fat distribution and visceral fat were assessed. During the proposed Phase 2, a series of nongentic studies will be undertaken on the HERITAGE family dataset. Physiological, behavioral and social determinants of maximal and submaximal indicators of cardiorespiratory endurance in the sedentary state and in the response to training will be investigated taking into account the contributions of age, gender and race. Similar analysis will be carried out on the CVD and NIDDM risk factors monitored in the study. Genetic analyses will determine the heritability levels, and test for paternal or maternal effects, major gene effects and segregation patterns which will be used to develop hypotheses concerning genetic bases of the response to endurance exercise. A panel of candidate genes will be typed and used for association ad linkage studies. Differential display analysis of skeletal muscle transcripts will be used to identify new candidate genes for the response to endurance exercise. Finally, a genome wide search will be undertaken to locate candidate genomic regions and positional candidate genes for the response of cardiorespiratory endurance and CVD and NIDDM risk factor phenotypes. This phase of the HERITAGE Family Study should increase our understanding of the differences between Blacks and whites for common CVD and NIDDM risk factors in the sedentary state and of the genetics of adaptation to regular endurance exercise in these risk factors with an emphasis on potential racial differences. This application is from the Laval University Clinical Center which also serves as the HERITAGE consortium Coordinating Center.

遗产家庭研究的目的是记录 对耐力运动训练的心血管和代谢反应， 以及遗传因素对伴随反应的贡献， 心血管疾病（CVD）和糖尿病（NIDDM）的危险因素。 一 由5所大学组成的联合会正在进行这项研究。 第一阶段（1992年- 1997年），约765名久坐不动的受试者进行了运动训练， 同样的节目20周。 在最终的主文件中 来自98个高加索血统家庭的约495名个体， 父母和生物成年后代和270个个体， 黑人家庭 训练前后，最大摄氧量和 对次最大和最大剂量的心血管和代谢反应 锻炼是测量的。 血脂、脂蛋白、载脂蛋白 酶、胰岛素和葡萄糖对静脉注射葡萄糖的反应 负荷，血浆性类固醇和糖皮质激素，休息和运动 血压、体脂、区域脂肪分布和内脏脂肪 进行了评估。 在拟议的第二阶段，一系列非基因 将对遗产家庭数据集进行研究。 生理、行为和社会决定因素， 久坐者心肺耐力的次最大指标 国家和培训响应将进行调查， 考虑到年龄、性别和种族的影响。 类似的分析将 对监测的心血管疾病和NIDDM危险因素进行监测， study. 遗传分析将确定遗传力水平，并测试 父系或母系效应、主基因效应和分离 这些模式将用于发展关于遗传学的假设， 耐力运动的反应基础。 候选人小组 基因将被分型并用于关联和连锁研究。 将使用骨骼肌转录本的差异显示分析 来识别新的候选基因， 锻炼的 最后，将进行全基因组搜索， 候选基因组区域和位置候选基因 心肺耐力反应与CVD和NIDDM风险 因子表型 遗产家庭研究的这一阶段 应该增加我们对黑人之间差异的理解 和白人的常见CVD和NIDDM危险因素， 久坐状态和适应规律耐力的遗传学 在这些危险因素中进行锻炼，重点是潜在的种族 差异 此应用程序来自拉瓦尔大学临床 该中心也作为遗产财团协调 中心