HERITAGE--GENETICS, RESPONSE TO EXERCISE, RISK FACTORS

遗产家族研究的目的是记录 耐力运动训练的心血管和代谢反应， 以及遗传因素对伴随反应的贡献。 心血管疾病(CVD)和糖尿病(NIDDM)危险因素。一个 由5所大学组成的联盟正在进行这项研究。第一阶段(1992- 1997年)，大约765名久坐的受试者接受了 同样的计划，为期20周。最终的主文件中会有 来自98个高加索后裔家庭的约495人，两者都有 父母和亲生成年后代以及102人中的270人 黑人家庭。训练前后最大摄氧量和最大摄氧量 次极量和最大量的心血管和代谢反应 对运动进行测量。血脂、脂蛋白、载脂蛋白 酶、胰岛素和葡萄糖对静脉注射葡萄糖的反应 负荷、血浆性类固醇和糖皮质激素、休息和运动 血压、体脂、局部脂肪分布和内脏脂肪 都进行了评估。在拟议的第二阶段期间，一系列非农 将对遗产家族数据集进行研究。 生理、行为和社会决定因素最大和 久坐状态下心肺耐力的次极值指标 将对培训的状态和反应进行调查，包括 考虑到年龄、性别和种族的贡献。类似的分析将 对监测的心血管疾病和非胰岛素依赖型糖尿病的危险因素进行 学习。遗传分析将确定遗传力水平，并测试 父系或母系效应、主基因效应和分离 这些模式将被用来发展关于基因的假说 耐力运动反应的基础。一组候选人 基因将被分型并用于关联和连锁研究。 将使用骨骼肌转录本的差异显示分析 寻找耐力反应的新候选基因 锻炼身体。最后，将进行全基因组搜索以定位 该基因的候选基因组区域和位置候选基因 心肺耐力与心血管疾病和非胰岛素依赖型糖尿病风险的关系 因子表型。遗产家庭研究的这一阶段 应该加深我们对黑人之间的差异的了解 白人是常见的心血管疾病和非胰岛素依赖型糖尿病的危险因素 久坐状态和适应规律耐力的遗传学 在这些危险因素中进行锻炼，重点是潜在的种族 不同之处。此应用程序来自拉瓦尔大学临床 该中心同时也是遗产协调财团 中心。

The aim of the HERITAGE Family Study is to document cardiovascular and metabolic responses to endurance exercise training, and the contribution of genetic factors to the concomitant response of cardiovascular disease (CVD) and diabetes (NIDDM) risk factors. A consortium of 5 universities is conducting the study. In Phase 1 (1992- 1997), about 765 sedentary subjects were exercise-trained with the same program for 20 weeks. There will be in the final master file about 495 individuals from 98 families of Caucasian descent with both parents and biological adult offspring and 270 individuals from 102 black families. Before and after training, maximal oxygen uptake and cardiovascular and metabolic responses to submaximal and maximal exercise were measured. Plasma lipids, lipoproteins, apolipoproteins and enzymes, insulin and glucose response to an intravenous glucose load, plasma sex steroids and glucocorticoids, resting and exercise blood pressures, and body fat, regional fat distribution and visceral fat were assessed. During the proposed Phase 2, a series of nongentic studies will be undertaken on the HERITAGE family dataset. Physiological, behavioral and social determinants of maximal and submaximal indicators of cardiorespiratory endurance in the sedentary state and in the response to training will be investigated taking into account the contributions of age, gender and race. Similar analysis will be carried out on the CVD and NIDDM risk factors monitored in the study. Genetic analyses will determine the heritability levels, and test for paternal or maternal effects, major gene effects and segregation patterns which will be used to develop hypotheses concerning genetic bases of the response to endurance exercise. A panel of candidate genes will be typed and used for association ad linkage studies. Differential display analysis of skeletal muscle transcripts will be used to identify new candidate genes for the response to endurance exercise. Finally, a genome wide search will be undertaken to locate candidate genomic regions and positional candidate genes for the response of cardiorespiratory endurance and CVD and NIDDM risk factor phenotypes. This phase of the HERITAGE Family Study should increase our understanding of the differences between Blacks and whites for common CVD and NIDDM risk factors in the sedentary state and of the genetics of adaptation to regular endurance exercise in these risk factors with an emphasis on potential racial differences. This application is from the Laval University Clinical Center which also serves as the HERITAGE consortium Coordinating Center.