NEURAL BASIS OF COMPLEX BEHAVIORS

复杂行为的神经基础

• 批准号: 2609425
• 负责人: ELIZABETH C CROPPER
• 金额: $ 7.26万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2609425
• 关键词: Aplysia; electrophysiology; intercellular connection; mechanoreceptors; neural information processing; neural plasticity; neural transmission; neurochemistry; neurotransmitters; nutrient intake activity; sensory receptors

This is an application for an ADAMHA Research Scientist Development Award (RSDA) My long-standing interest in the neural basis of behavior has driven me to pursue an academic career as a neuroscientist. I am requesting this award because I am at a critical stage in my career. I recently obtained my first appointment as a tenure-track faculty member. Consequently, my institutional obligations have increased, and I have less time for research. I am, however, at a point where I need to develop scientifically. I need to collaborate with others and acquire skills, so that my research will not be limited by my technical abilities. Additionally, I need to interact with other faculty members and broaden my research program. Interactions will occur between myself and other members of the Physiology Department. Additionally, I will interact with members of the Fishberg Center for Neurobiological Research. Thus, in recent years Mt. Sinai has made a major commitment to the study of mental health. This interest has been reflected in recruitment policies; e.g., there are 6 Neuroscience faculty members with primary appointments in the Department of Physiology, and 9 faculty members with primary appointments in the Fishberg Center. With this award I will increase my interactions with the well-established Neuroscience community that has formed at Mt. Sinai. In addition to enhancing my own scientific development, this award will benefit others that will train with me. My postdoctoral years were spent in a large lab that functioned as a supportive, collaborative unit. I prospered in this environment and tend to recreate it, by establishing an active laboratory that includes both graduate students and postdocs. This award, which will relieve me of most of my teaching and administrative obligations, will make a critical difference to my development as a scientist. Additionally, it will enable me to devote time to the training of others. The long term goal of my research is to characterize cellular and molecular mechanisms that endow organisms with the ability to adapt to changes in the external environment. Immediate experiments will determine how the mollusk Aplysia makes a switch between two types of related, but distinctly different, rhythmic behaviors. I have developed a model that postulates that switches from one behavior to the other result from the phasic activity of sensory neurons. These sensory neurons contain both primary neurotransmitters and modulatory peptide cotransmitters. My work is, therefore, relevant to studies of plasticity in any rhythmic behavior that must accommodate changes in the external environment in a coordinated fashion. Additionally, I postulate a novel conceptualization of the physiological significance of the presence of primary transmitters and cotransmitters in neurons triggering switches from one behavior to another. This data will help guide future studies of the role of neuromodulation in circuit selection, and may provide insights into dysfunctions of the nervous system that occur when cognitive processes necessary for the proper choice of behavior are perturbed, as is the case with obsessions and compulsions. Thus, this research is directly relevant to the mission of the NIMH.

这是对ADAMHA研究科学家发展奖的申请 (RSDA)我对行为的神经基础的长期兴趣已经 促使我追求作为一名神经学家的学术生涯。我是 之所以要求这个奖项，是因为我正处于职业生涯的关键阶段。我 最近，我第一次获得终身教职。 因此，我的机构义务增加了，我也 更少的研究时间。然而，我正处在一个需要发展的阶段 从科学上讲。我需要与他人合作并获得技能，所以 我的研究不会受到我的技术能力的限制。 此外，我需要与其他教职员工互动，拓宽 我的研究项目。我和其他人之间会发生互动 生理系的成员。此外，我还将与 菲什伯格神经生物学研究中心的成员。因此，在 近几年来，Mt.西奈半岛对精神疾病的研究做出了重大承诺 健康。这种兴趣已反映在征聘政策中；例如， 有6名神经科学教职员工在这里接受了初级任命 生理系和9名初级教职员工 在菲什伯格中心。有了这个奖项，我将增加我的互动 与山上已经形成的完善的神经科学社区。 西奈半岛。除了加强我自己的科学发展，这个奖项 将有益于其他将与我一起训练的人。我的博士后生涯是 在一个大型实验室里度过，这个实验室起到了支持性、协作性的作用。 我在这个环境中取得了成功，并倾向于通过建立 既有研究生也有博士后的活跃实验室。 这个奖项，它将使我摆脱大部分的教书和 行政义务，将对我的 作为科学家的发展。此外，这将使我能够致力于 训练别人的时间到了。 我研究的长期目标是将细胞和 赋予生物体适应能力的分子机制 外部环境的变化。即刻的实验将确定 软体动物海兔是如何在两种类型的亲缘关系之间切换的，但 截然不同的，有节奏的行为。我开发了一种模型， 假设从一种行为切换到另一种行为的结果是 感觉神经元的时相活动。这些感觉神经元既包含 初级神经递质和调节性多肽共递质。我的作品 因此，与研究任何节律行为的可塑性有关 中的外部环境的更改。 协调一致的时尚。此外，我假设了一种新的概念化 初级递质存在的生理意义 神经元中的共递质触发从一种行为到 又一个。这些数据将有助于指导未来对 在电路选择中的神经调节，并可能提供对 在认知过程中发生的神经系统功能障碍 对于正确的行为选择是必要的，情况也是如此 痴迷和强迫症。因此，这项研究是直接相关的。 NIMH的使命。