DIET--ENDOCRINE STUDY OF BREAST AND PROSTATE CANCER

前列腺癌和乳腺癌几乎占所有癌症的三分之一。 癌症在美国这些肿瘤， 在美国， 男人和女人尽管存在明显的性别差异，但这些癌症都有一个共同点， 共同的基础（如。相似的发病率，平行 流行病学与各种因素的关系（高脂肪饮食，肥胖， 等等）。和类似的提出的发病机制的途径]。一个学术 奖励旨在扩大申请人对以下方面的理解： 这些与癌症有关的疾病。这项工作是由主要导师赞助的 芭芭拉·里默，博士，有相关计划的经验 导演：James Iglehart，M.D. Eric Winer，医学博士，克劳德·休斯医学博士 哲学博士、和医学博士卡里·罗伯逊杜克和北方大学 卡罗莱纳的保罗·戈德利医学博士，博士和博伊德·斯威策博士最终 拟议计划的目标是为申请人提供一个工作 前列腺癌和乳腺癌、内分泌学和分子生物学 生物学/遗传调控-知识基础，将补充她 作为营养学家的技能，使她能够确定适当的 这些地区营养干预的中间终点。这 培训将为申请人提供必要的跳板， 在这些领域的翻译研究，并有机会成为一个 预防肿瘤学的独立研究员 研究项目是拟议培训的重点，将 允许研究者扩大并继续其对饮食、身体 脂肪及其分布，以及它们与 肿瘤性疾病这项研究的题目是“探索和干预， 乳腺癌辅助化疗相关的体重增加。" 体重增加是一种常见的副作用，在妇女接受佐剂 乳腺癌的化疗-一个一直被报道 在过去的二十年里。对于某些疗法，增益超过22 四分之一的女性体重超标。这种体重增加可能是 不受欢迎。 首先，它可能会产生深刻的负面心理影响 一群自我意识已经受损的病人身上 尊重其次，最近的研究结果表明，治疗期间体重增加是 与生存率下降有关。虽然在辅助治疗期间体重增加 乳腺癌的化疗在临床上很受欢迎， 已经进行了研究以调查 这种能量不平衡。只有在以下情况下才能制定适当的干预措施： 这是已知的。 本研究的具体目的如下：1） 量化能量摄入和能量特定成分的变化 支出（即。静息代谢率、饮食诱导产热和 100例绝经前乳腺癌患者， 辅助化疗[6个月环磷酰胺+ 甲氨蝶呤+ 5氟尿嘧啶（CMF）或环磷酰胺+多柔比星+ 5 氟尿嘧啶（CAF）]和2）使用这项拟议研究的结果 制定适当的干预措施，以防止体重增加， 人口这一研究途径有可能增加 乳腺癌患者的生活质量和数量 辅助化疗，同时使我们的整体贡献， 了解体重和癌症。

Cancers of the prostate and breast constitute almost one-third of all cancers in the United States. These neoplasms, which have been characterized as hormonally-linked, are the leading cancers in American men and women. Despite obvious gender differences, these cancers share a substantial common ground [eg. similar rates of incidence, parallel epidemiologic relationships to various factors (high fat diet, obesity, etc.) and analogous proposed pathways of etiopathogenesis]. An academic award is sought in efforts to broaden the applicant's understanding of these hormone-related cancers. This effort is sponsored by primary mentor Barbara Rimer, Dr.PH, with planned experiences in relevant programs directed by James Iglehart, M.D., Eric Winer, M.D., Claude Hughes, M.D., Ph.D., and Cary Robertson, M.D. of Duke, and University of North Carolina's Paul Godley, M.D., Ph.D. and Boyd Switzer, Ph.D. The ultimate goal of the proposed program is to provide the applicant with a working knowledge-base in prostate and breast cancer, endocrinology and molecular biology/genetic regulation - a knowledge base that would complement her skills as a nutritionist and enable her to identify appropriate intermediate end points for nutrition intervention in these areas. This training will afford the applicant the springboard necessary for translational research in these areas and the opportunity to become an independent investigator in preventive oncology. A research project is a focal piece of the proposed training, and will permit the investigator to broaden and continue her interest in diet, body fat and its distribution, and their relationship to the continuum of neoplastic disease. The study is entitled "Exploration and Intervention in Weight Gain Associated with Adjuvant Chemotherapy for Breast Cancer." Weight gain is a common side effect in women receiving adjuvant chemotherapy for breast cancer - one that has been consistently reported throughout the past twenty years. For some therapies, gains of over 22 pounds are seen in one out of four women. This weight gain may be undesirable. First, it may have a profoundly negative psychosocial impact on a group of patients who may already have a compromised sense of self esteem. Second, recent findings suggest that weight gain during therapy is associated with decreased survival. Although weight gain during adjuvant chemotherapy for breast cancer is well-appreciated clinically, little research has been conducted to investigate the underlying mechanisms of this energy imbalance. Appropriate interventions cannot be developed until this is known. The specific aims of the proposed research are as follows: 1) to quantitate changes in energy intake and specific components of energy expenditure (ie. resting metabolic rate, diet-induced thermogenesis and physical activity) in 100 premenopausal breast cancer patients receiving adjuvant chemotherapy [six month regimens of cyclophosphamide + methotrexate + 5 fluorouracil (CMF) or cyclophosphamide + doxarubacin + 5 fluorouracil (CAF)] and 2) to use the findings of this proposed research to develop an appropriate intervention to prevent weight gain in this population. This research avenue has the potential to increase both the quantity and quality of life for breast cancer patients undergoing adjuvant chemotherapy, while making an overall contribution to our understanding of body weight and cancer.