PROMOTING HEALTH IN PROSTATE & BREAST CANCER

促进前列腺健康

• 批准号: 6489300
• 负责人: WENDY DEMARK-WAHNEFRIED
• 金额: $ 42.11万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6489300
• 关键词: behavior modification; body weight; breast neoplasms; carotenoids; clinical research; computer assisted instruction; depression; education evaluation /planning; female; fruit; gender difference; health behavior; health education; human subject; male; nutrition aspect of cancer; nutrition related tag; physical fitness; prostate neoplasms; quality of life; racial /ethnic difference; vegetables; women's health

DESCRIPTION:This year, nearly 1.4 million Americans will be diagnosed with cancer. Most will survive 5 years and be considered "cured." However, cancer survivors are at increased risk for developing other cancers, diabetes and/or cardiovascular disease. Reasons for increased risk across conditions may be genetic, treatment-related or because common lifestyle factors increase risk for more than one disease. Thus, if cancer survivors adopt healthier lifestyles, they also may reduce their risk for secondary cancers and other chronic disorders. Our preliminary study data on 988 prostate and breast cancer patients suggest that cancer survivors are exceptionally receptive toward improving their diet and physical activity behaviors, and that the cancer diagnosis may render a" teachable moment." Few efforts have capitalized on this apparent opportunity to promote behavioral change within this high risk population - one reason may be the barrier of distance (travel), which cancer survivors list as a leading reason for non-participation in health promotion programs. Fortunately, there are several ways to overcome this barrier. An experienced team of investigators in the fields of nutrition, exercise, behavior, aging, biostatistics & medical informatics at Duke Univ. Med. Ctr. proposes to test the efficacy of a tailored correspondence course in changing both diet & physical activity behaviors. We will recruit 530 early stage prostate & breast cancer patients in 25 NC counties & randomize them to: 1) a group that receives a 10 mth. tailored correspondence course that promotes increased physical activity, a low fat diet, and increased fruit & vegetable intake; or 2) a usual care control group that receives information in unrelated areas. Intervention efficacy will be gauged by the proportion of participants in the intervention arm who adopt two or more goal behaviors compared to control group participants. The purpose of this study is to determine: 1) the relative short (post-intervention) & long-term (1 yr follow-up) efficacy of this personalized, computer-generated intervention; 2) the effects of the intervention on other endpoints (quality of life, perceived health, etc); & 3) factors, such as gender & race that may interact with the intervention in predicting program efficacy. If effective, this program could be modified, easily disseminated & used in a variety of health care settings, thus having broad public health impact.

描述：今年，将有近140万美国人被诊断出患有 癌症。大多数人将生存5年，并被视为“治愈”。但是，癌症 幸存者患其他癌症，糖尿病和/或 心血管疾病。跨条件增加风险的原因可能是 遗传，与治疗有关或因为常见的生活方式因素增加风险 对于多种疾病。因此，如果癌症幸存者采用更健康的 生活方式，它们还可能降低其中期癌和其他癌症的风险 慢性疾病。我们关于988前列腺和乳腺癌的初步研究数据 患者认为癌症幸存者对 改善他们的饮食和体育锻炼行为，并提高癌症 诊断可能会导致“可教的时刻”。很少为此努力 明显的机会来促进这种高风险内的行为改变 人口 - 一个原因之一可能是距离（旅行）的障碍，癌症 幸存者列表是健康促进参与的主要原因 程序。幸运的是，有几种克服这一障碍的方法。 一个经验丰富的研究人员团队，在营养，锻炼领域， 杜克大学的行为，老化，生物统计学和医学信息学。医学CTR。 建议测试量身定制的对应课程在更改中的功效 饮食和体育锻炼行为。我们将招募530个早期舞台 25 NC县的前列腺和乳腺癌患者，并将其随机为：1）A 获得10个月的小组。额定的促进信函课程 增加体育锻炼，低脂饮食以及果实和蔬菜的增加 进气或2）接收无关信息的通常的护理控制组 区域。参与者比例将衡量干预功效 在干预部门中，他们采用了两个或多个目标行为 对照组参与者。这项研究的目的是确定：1​​） 相对短期（干预后）和长期（1年随访）的功效 这种个性化的计算机生成的干预措施； 2） 干预其他终点（生活质量，感知的健康等）； ＆3） 可能与性别与种族的因素可能与干预相互作用 预测程序功效。如果有效，可以修改该程序， 在各种医疗机构中易于传播和使用，因此 广泛的公共卫生影响。