PROMOTING HEALTH IN PROSTATE & BREAST CANCER

促进前列腺健康

• 批准号: 6701166
• 负责人: WENDY DEMARK-WAHNEFRIED
• 金额: $ 7.08万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6701166
• 关键词: behavior modification; body weight; breast neoplasms; carotenoids; clinical research; computer assisted instruction; depression; education evaluation /planning; female; fruit; gender difference; health behavior; health education; human subject; male; nutrition aspect of cancer; nutrition related tag; physical fitness; prostate neoplasms; quality of life; racial /ethnic difference; vegetables; women's health

DESCRIPTION:This year, nearly 1.4 million Americans will be diagnosed with cancer. Most will survive 5 years and be considered "cured." However, cancer survivors are at increased risk for developing other cancers, diabetes and/or cardiovascular disease. Reasons for increased risk across conditions may be genetic, treatment-related or because common lifestyle factors increase risk for more than one disease. Thus, if cancer survivors adopt healthier lifestyles, they also may reduce their risk for secondary cancers and other chronic disorders. Our preliminary study data on 988 prostate and breast cancer patients suggest that cancer survivors are exceptionally receptive toward improving their diet and physical activity behaviors, and that the cancer diagnosis may render a" teachable moment." Few efforts have capitalized on this apparent opportunity to promote behavioral change within this high risk population - one reason may be the barrier of distance (travel), which cancer survivors list as a leading reason for non-participation in health promotion programs. Fortunately, there are several ways to overcome this barrier. An experienced team of investigators in the fields of nutrition, exercise, behavior, aging, biostatistics & medical informatics at Duke Univ. Med. Ctr. proposes to test the efficacy of a tailored correspondence course in changing both diet & physical activity behaviors. We will recruit 530 early stage prostate & breast cancer patients in 25 NC counties & randomize them to: 1) a group that receives a 10 mth. tailored correspondence course that promotes increased physical activity, a low fat diet, and increased fruit & vegetable intake; or 2) a usual care control group that receives information in unrelated areas. Intervention efficacy will be gauged by the proportion of participants in the intervention arm who adopt two or more goal behaviors compared to control group participants. The purpose of this study is to determine: 1) the relative short (post-intervention) & long-term (1 yr follow-up) efficacy of this personalized, computer-generated intervention; 2) the effects of the intervention on other endpoints (quality of life, perceived health, etc); & 3) factors, such as gender & race that may interact with the intervention in predicting program efficacy. If effective, this program could be modified, easily disseminated & used in a variety of health care settings, thus having broad public health impact.

今年，近140万美国人将被诊断出患有 癌大多数人将存活5年，并被认为是“治愈”。“然而，癌症 幸存者患其他癌症、糖尿病和/或 心血管疾病各种情况下风险增加的原因可能是 遗传、治疗相关或由于常见的生活方式因素增加风险 不止一种疾病。因此，如果癌症幸存者采用更健康的 生活方式，他们也可以降低患继发性癌症和其他癌症的风险。 慢性疾病我们对988例前列腺癌和乳腺癌的初步研究数据 病人们认为癌症幸存者特别容易接受 改善他们的饮食和身体活动行为， 诊断可以提供一个”可教的时刻。“很少有努力利用这一点 在这种高风险环境下促进行为改变的明显机会 人口-一个原因可能是距离的障碍（旅行），癌症 幸存者被列为不参与健康促进的主要原因 程序.幸运的是，有几种方法可以克服这一障碍。 一个在营养、运动、 行为，衰老，生物统计学和医学信息学在杜克大学医学中心。 建议测试一个量身定制的函授课程在改变 饮食和身体活动行为。我们将招募530名早期 在25个NC县的前列腺癌和乳腺癌患者中，将他们随机分为：1）a 一个10个月的小组。定制函授课程，促进 增加体力活动，低脂饮食，增加水果和蔬菜 摄入量;或2）接受不相关信息的常规护理对照组 地区干预效果将通过参与者的比例来衡量 在干预组中，采用两种或两种以上目标行为的人， 对照组参与者。本研究的目的是确定：1） 相对短期（干预后）和长期（1年随访）疗效 这种个性化的，计算机生成的干预; 2）的影响， 对其他终点的干预（生活质量，感知健康等）; 3） 因素，如性别和种族，可能与干预措施相互作用， 预测程序的有效性。如果有效的话，这个计划可以修改， 易于传播和用于各种医疗保健环境，因此具有 广泛的公共卫生影响。