PROMOTING HEALTH IN PROSTATE & BREAST CANCER

促进前列腺健康

• 批准号: 6701166
• 负责人: WENDY DEMARK-WAHNEFRIED
• 金额: $ 7.08万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6701166
• 关键词: behavior modification; body weight; breast neoplasms; carotenoids; clinical research; computer assisted instruction; depression; education evaluation /planning; female; fruit; gender difference; health behavior; health education; human subject; male; nutrition aspect of cancer; nutrition related tag; physical fitness; prostate neoplasms; quality of life; racial /ethnic difference; vegetables; women's health

DESCRIPTION:This year, nearly 1.4 million Americans will be diagnosed with cancer. Most will survive 5 years and be considered "cured." However, cancer survivors are at increased risk for developing other cancers, diabetes and/or cardiovascular disease. Reasons for increased risk across conditions may be genetic, treatment-related or because common lifestyle factors increase risk for more than one disease. Thus, if cancer survivors adopt healthier lifestyles, they also may reduce their risk for secondary cancers and other chronic disorders. Our preliminary study data on 988 prostate and breast cancer patients suggest that cancer survivors are exceptionally receptive toward improving their diet and physical activity behaviors, and that the cancer diagnosis may render a" teachable moment." Few efforts have capitalized on this apparent opportunity to promote behavioral change within this high risk population - one reason may be the barrier of distance (travel), which cancer survivors list as a leading reason for non-participation in health promotion programs. Fortunately, there are several ways to overcome this barrier. An experienced team of investigators in the fields of nutrition, exercise, behavior, aging, biostatistics & medical informatics at Duke Univ. Med. Ctr. proposes to test the efficacy of a tailored correspondence course in changing both diet & physical activity behaviors. We will recruit 530 early stage prostate & breast cancer patients in 25 NC counties & randomize them to: 1) a group that receives a 10 mth. tailored correspondence course that promotes increased physical activity, a low fat diet, and increased fruit & vegetable intake; or 2) a usual care control group that receives information in unrelated areas. Intervention efficacy will be gauged by the proportion of participants in the intervention arm who adopt two or more goal behaviors compared to control group participants. The purpose of this study is to determine: 1) the relative short (post-intervention) & long-term (1 yr follow-up) efficacy of this personalized, computer-generated intervention; 2) the effects of the intervention on other endpoints (quality of life, perceived health, etc); & 3) factors, such as gender & race that may interact with the intervention in predicting program efficacy. If effective, this program could be modified, easily disseminated & used in a variety of health care settings, thus having broad public health impact.

描述：今年，近 140 万美国人将被诊断出患有 癌症。大多数可以存活 5 年并被视为“治愈”。然而，癌症 幸存者患其他癌症、糖尿病和/或 心血管疾病。不同条件下风险增加的原因可能是 遗传、治疗相关或常见的生活方式因素会增加风险 对于不止一种疾病。因此，如果癌症幸存者采用更健康的方式 生活方式，他们还可以降低继发性癌症和其他疾病的风险 慢性疾病。我们对 988 例前列腺癌和乳腺癌的初步研究数据 患者表示癌症幸存者特别容易接受 改善他们的饮食和身体活动行为，并且癌症 诊断可能会带来“受教时刻”。很少有努力利用这一点 在这种高风险中促进行为改变的明显机会 人口——原因之一可能是距离（旅行）的障碍，这是癌症 幸存者将其列为不参与健康促进的主要原因 程序。幸运的是，有多种方法可以克服这一障碍。 一支在营养、运动、 杜克大学的行为、衰老、生物统计学和医学信息学。医学。中心。 建议测试量身定制的函授课程在改变 饮食和身体活动行为。前期招募530名 北卡罗来纳州 25 个县的前列腺癌和乳腺癌患者并将他们随机分为：1) a 接受 10 个月的组。量身定制的函授课程，促进 增加体力活动、低脂饮食以及增加水果和蔬菜 摄入量；或 2) 常规护理对照组，以不相关的方式接收信息 地区。干预效果将根据参与者的比例来衡量 在干预组中，与相比，采取了两种或更多目标行为 对照组参与者。本研究的目的是确定：1​​） 相对短期（干预后）和长期（1 年随访）疗效 这种个性化的、计算机生成的干预； 2) 的影响 对其他终点的干预（生活质量、感知健康等）； &3) 可能与干预相互作用的因素，例如性别和种族 预测计划效果。如果有效，可以修改该程序， 易于在各种医疗保健环境中传播和使用，从而 广泛的公共卫生影响。