ALCOHOL CONSUMPTION PATTERNS, BIOMARKERS AND HEALTH

酒精消费模式、生物标志物与健康

• 批准号: 2769192
• 负责人: ERIC B RIMM
• 金额: $ 30.16万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2769192
• 关键词: alcoholic beverage consumption; behavioral /social science research tag; biomarker; blood chemistry; cardiovascular disorder epidemiology; clinical research; coronary disorder; diabetes mellitus; diet; disease /disorder proneness /risk; fibrinogen; high density lipoproteins; human middle age (35-64); human mortality; human subject; hypertension; lifestyle; longitudinal human study; nutrition related tag; plasminogen activator; questionnaires; substance abuse epidemiology; von Willebrand factor; young adult human (21-34)

We propose to evaluate, prospectively, the impact of moderate daily alcohol consumption, regular weekly patterns of consumption, and usual percent of alcohol consumed with meals, on risk of diabetes mellitus, hypertension, cardiovascular disease and total mortality in large cohort studies of 51,529 middle-aged men who were 40 to 75 years of age at baseline in 1986 (Health Professionals Follow-up Study), and 116,601 young women who were 25 to 42 years of age at baseline in 1989 (Nurses' Health Study II). In addition, using samples (n=500 men and 500 women) of stored plasma from 18,018 men who provided blood specimens in 1993-94 and from an anticipated 40,000 women who will provede blood samples in 1995-96, we propose to evaluate the impact of moderate alcohol consumption on plasma lipids and thrombotic factors related to risk of coronary heart disease. Using a cross-sectional design we propose to evaluate the relationship between alcohol consumption patterns and levels of plasma HDL-cholesterol, tissue-type plasminogen activator (t-PA), fibrinogen, factor VII activity, and von Willebrand Factor independent of obesity, physical activity, and dietary intake of saturated fac, cholesterol, and total energy. Finally, in a nested case-control study of CHD, we propose to evaluate simultaneously the relationship between alcohol consumption patterns, biomarkers, and risk of coronary heart disease to quantitate the importanceof each biomarker in explaining the reported inverse association between alcohol consumption and risk of coronary heart disease. The ongoing HPFS (CA55075 HL35464) and NHS II (CA50385) will provide follow-up and documentation of hypertension, cardiovascular disease, and mortality in addition tocovariate information. Overall, the large size of these cohorts, the prospective design, the high follow-up rates, the detailed alcohol data, and the availability of archived blood specimens provide a unique opportunity to test a number of hypotheses of public health importance, using a highly cost-effective design.

我们建议前瞻性地评估每日适量饮食的影响。 饮酒，每周规律的消费模式，以及 与糖尿病风险相关的正常饮酒量百分比 糖尿病、高血压、心血管疾病和总死亡率 在对51,529名40岁至75岁的中年男性进行的大型队列研究中 1986年基线年龄(卫生专业人员随访 研究)，以及116,601名年龄在25岁至42岁之间的年轻女性 1989年基线(护士健康研究二)。此外，使用 18018名男性的储存血浆样本(n=500名男性和500名女性) 世卫组织在1993-94年间提供了血液样本，预计 在1995-96年度将提供血液样本的40,000名妇女，我们建议 评价适量饮酒对血浆的影响 与冠心病危险相关的血脂和血栓形成因素 疾病。我们建议使用横断面设计来评估 饮酒方式与饮酒水平的关系 血浆高密度脂蛋白、组织型纤溶酶原激活物(t-PA)、 纤维蛋白原、凝血因子VII活性与血管性血友病因子 与肥胖、体力活动和饮食摄入量无关 饱和的面部脂肪、胆固醇和总能量。最后，在嵌套的 冠心病的病例对照研究，我们建议同时评价 酒精消费模式、生物标志物和 量化每个因素对冠心病风险的重要性 生物标记物在解释已报道的 饮酒和患冠心病的风险。正在进行的 HPFS(CA55075 HL35464)和NHS II(CA50385)将提供后续行动 和高血压、心血管疾病的记录，以及 除协变量信息外的死亡率。总体而言，大型 这些队列的规模、前瞻性设计、高随访率 价格，详细的酒精数据，以及存档的可用性 血液样本提供了一个独特的机会来检测许多 公共卫生重要性的假设，使用高成本效益的 设计。