ALCOHOL CONSUMPTION PATTERNS, BIOMARKERS AND HEALTH

我们建议前瞻性地评估每日适量 酒精消费，每周定期消费模式，以及 与餐同饮的通常酒精百分比，对糖尿病的风险 高血压、心血管疾病和总死亡率 在对51,529名40至75岁的中年男性进行的大型队列研究中， 1986年基线时的年龄（卫生专业人员随访 研究），以及116，601名年龄在25至42岁之间的年轻女性， 1989年的基线（护士健康研究II）。 此外，使用 来自18，018名男性的储存血浆样本（n=500名男性和500名女性） 他们在1993-94年提供了血液样本， 我们建议在1995- 1996年提供40，000名妇女的血样， 评估适度饮酒对血浆的影响 血脂和血栓形成因素与冠心病危险性的关系 疾病 使用横截面设计，我们建议评估 酒精消费模式与酒精摄入水平之间的关系 血浆HDL-胆固醇、组织型纤溶酶原激活物（t-PA）、 纤维蛋白原、因子VII活性和血管性血友病因子 独立于肥胖，体力活动和饮食摄入量， 饱和脂肪、胆固醇和总能量。 最后，在嵌套的 冠心病的病例对照研究，我们建议同时评估 酒精消费模式、生物标志物和 冠心病的风险，以量化每个的重要性， 生物标志物在解释报告的负相关之间 饮酒和冠心病的风险。 正在进行的 HPFS（CA 55075和HL 35464）和NHS II（CA 50385）将提供随访 高血压、心血管疾病和 死亡率以及协变量信息。 总体而言， 这些队列的规模、前瞻性设计、高随访率 率，详细的酒精数据，以及存档的可用性 血液标本提供了一个独特的机会，以测试一些 公共卫生重要性的假设，使用具有高度成本效益的 设计

We propose to evaluate, prospectively, the impact of moderate daily alcohol consumption, regular weekly patterns of consumption, and usual percent of alcohol consumed with meals, on risk of diabetes mellitus, hypertension, cardiovascular disease and total mortality in large cohort studies of 51,529 middle-aged men who were 40 to 75 years of age at baseline in 1986 (Health Professionals Follow-up Study), and 116,601 young women who were 25 to 42 years of age at baseline in 1989 (Nurses' Health Study II). In addition, using samples (n=500 men and 500 women) of stored plasma from 18,018 men who provided blood specimens in 1993-94 and from an anticipated 40,000 women who will provede blood samples in 1995-96, we propose to evaluate the impact of moderate alcohol consumption on plasma lipids and thrombotic factors related to risk of coronary heart disease. Using a cross-sectional design we propose to evaluate the relationship between alcohol consumption patterns and levels of plasma HDL-cholesterol, tissue-type plasminogen activator (t-PA), fibrinogen, factor VII activity, and von Willebrand Factor independent of obesity, physical activity, and dietary intake of saturated fac, cholesterol, and total energy. Finally, in a nested case-control study of CHD, we propose to evaluate simultaneously the relationship between alcohol consumption patterns, biomarkers, and risk of coronary heart disease to quantitate the importanceof each biomarker in explaining the reported inverse association between alcohol consumption and risk of coronary heart disease. The ongoing HPFS (CA55075 HL35464) and NHS II (CA50385) will provide follow-up and documentation of hypertension, cardiovascular disease, and mortality in addition tocovariate information. Overall, the large size of these cohorts, the prospective design, the high follow-up rates, the detailed alcohol data, and the availability of archived blood specimens provide a unique opportunity to test a number of hypotheses of public health importance, using a highly cost-effective design.