ALCOHOL CONSUMPTION PATTERNS, BIOMARKERS AND HEALTH

我们建议前瞻性地评估适度日常活动的影响 饮酒量、每周有规律的消费模式，以及 通常用餐时饮酒的百分比与患糖尿病的风险有关 糖尿病、高血压、心血管疾病和总死亡率 对 51,529 名 40 至 75 岁中年男性的大型队列研究 1986 年基线年龄（卫生专业人员随访 研究），以及 116,601 名 25 至 42 岁的年轻女性 1989 年为基线（护士健康研究 II）。 此外，使用 来自 18,018 名男性的储存血浆样本（n=500 名男性和 500 名女性） 谁在 1993-94 年提供了血液样本，并来自预期的 我们提议在 1995-96 年对 40,000 名妇女进行血液样本检验 评估适量饮酒对血浆的影响 与冠心病风险相关的血脂和血栓因素 疾病。 我们建议使用横截面设计来评估 饮酒模式与酒精水平之间的关系 血浆高密度脂蛋白胆固醇、组织型纤溶酶原激活剂（t-PA）、 纤维蛋白原、因子 VII 活性和冯维勒布兰德因子 与肥胖、体力活动和饮食摄入量无关 饱和脂肪酸、胆固醇和总能量。 最后，在嵌套中 CHD 病例对照研究，我们建议同时评估 饮酒模式、生物标志物和酒精摄入量之间的关系 冠心病的风险量化每一项的重要性 生物标志物解释了所报告的负相关性 饮酒与冠心病的风险。 正在进行的 HPFS (CA55075 HL35464) 和 NHS II (CA50385) 将提供后续服务 以及高血压、心血管疾病的记录 除协变量信息外还包括死亡率。 总体而言，大 这些队列的规模、前瞻性设计、高随访率 费率、详细的酒精数据以及存档的可用性 血液样本提供了一个独特的机会来测试许多 公共卫生重要性的假设，使用极具成本效益的方法 设计。

We propose to evaluate, prospectively, the impact of moderate daily alcohol consumption, regular weekly patterns of consumption, and usual percent of alcohol consumed with meals, on risk of diabetes mellitus, hypertension, cardiovascular disease and total mortality in large cohort studies of 51,529 middle-aged men who were 40 to 75 years of age at baseline in 1986 (Health Professionals Follow-up Study), and 116,601 young women who were 25 to 42 years of age at baseline in 1989 (Nurses' Health Study II). In addition, using samples (n=500 men and 500 women) of stored plasma from 18,018 men who provided blood specimens in 1993-94 and from an anticipated 40,000 women who will provede blood samples in 1995-96, we propose to evaluate the impact of moderate alcohol consumption on plasma lipids and thrombotic factors related to risk of coronary heart disease. Using a cross-sectional design we propose to evaluate the relationship between alcohol consumption patterns and levels of plasma HDL-cholesterol, tissue-type plasminogen activator (t-PA), fibrinogen, factor VII activity, and von Willebrand Factor independent of obesity, physical activity, and dietary intake of saturated fac, cholesterol, and total energy. Finally, in a nested case-control study of CHD, we propose to evaluate simultaneously the relationship between alcohol consumption patterns, biomarkers, and risk of coronary heart disease to quantitate the importanceof each biomarker in explaining the reported inverse association between alcohol consumption and risk of coronary heart disease. The ongoing HPFS (CA55075 HL35464) and NHS II (CA50385) will provide follow-up and documentation of hypertension, cardiovascular disease, and mortality in addition tocovariate information. Overall, the large size of these cohorts, the prospective design, the high follow-up rates, the detailed alcohol data, and the availability of archived blood specimens provide a unique opportunity to test a number of hypotheses of public health importance, using a highly cost-effective design.