Validity of Diet and Activity Measures in Men

男性饮食和活动措施的有效性

• 批准号: 8548284
• 负责人: ERIC B RIMM
• 金额: $ 97.21万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-29 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8548284
• 关键词: African American; Animals; Area; Basal metabolic rate; Biological Markers; Blood specimen; Boston; Calibration; Cancer Etiology; Carotenoids; Chronic Disease; Clinical; Cohort Studies; Collection; Communities; Complement; Country; DEXA; Data; Databases; Diet; Diet Records; Dietary Assessment; Dietary Fats; Dietary intake; Disease; Eating; Energy Intake; Energy Metabolism; Epidemiology; Evaluation; Fasting; Fatty Acids; Folate; Food; Frequencies; Funding; Future; Gender; Health Professional; Healthcare; Height; Hour; Incidence; Indirect Calorimetry; Intake; Investigation; Label; Lipids; Literature; Malignant Neoplasms; Measurement; Measures; Methods; Monitor; Morphologic artifacts; Motion; Nitrogen; Nurses' Health Study; Nutrient; Online Systems; Paper; Participant; Patient Self-Report; Physical activity; Plasma; Potassium; Potential Energy; Prospective Studies; Proteins; Public Health; Publishing; Pulse Rates; Questionnaires; Records; Relative (related person); Relative Risks; Request for Proposals; Research Design; Research Personnel; Rest; Self-Administered; Series; Sodium; Stimulus; Structure; System; Time; Validation; Variant; Water; Weight; Woman; base; cohort; design; diet and cancer; disorder risk; follow-up; instrument; malignant breast neoplasm; men; protein intake; public health relevance; response; time interval; urinary; validation studies

DESCRIPTION (provided by applicant): Large prospective studies of diet and cancer have often not supported hypotheses that were based on animal and ecological findings; one possible explanation could be large measurement errors in the assessment of diet. Thus, NCI had requested proposals for a series of collaborative validation/calibration studies imbedded in existing cohorts using a common design with multiple self-reported and biomarker measures of diet and physical activity including doubly labeled water (DLW), urinary nitrogen (UN) and motion monitors. We therefore propose to conduct such a study among 750 men. The proposed study will complement a very similar study that NCI is funding in women, utilizing many of the same methods, among participants in the Nurses' Health Studies. The two studies will provide substantial synergy. For the proposed study, 375 men will be participants in the ongoing Health Professionals Follow-up Study (HPFS), which will be of particular value because of the rich data already collected. The other 375 participants will be drawn from Harvard Pilgrim Health Care, a Boston-area HMO. This participant pool will permit a broader representation of the community, with oversampling of African-Americans, and the potential with linkage to the clinical database. In HPFS, we have already collected extensive dietary data using multiple measures of intake and plasma biomarkers of diet; this will allow the evaluation of the validity of dietary assessment methods over a 23-year period. The proposed study design will consist of two FFQ's one year apart; in the year between these measures we will collect four NCI automated self-administered 24-hour recalls (ASA24), two 7-day dietary records, and biomarkers of diet including one assessment of energy expenditure using doubly-labeled water (DLW), four 24-hour urinary measures of nitrogen (a measure of protein intake), sodium and potassium, and two fasting blood samples for assessment of fatty acids, standard lipids, carotenoids, and folate. Physical activity will be assessed twice (together with the FFQ's) by the modified Paffenbarger physical activity questionnaire, by four 24-hour recalls using an automated system developed by the NCI, twice by an objective physical activity monitor, and by DLW. In the 575 men from the Boston area (from the HPFS and the HMO), we will also assess DEXA and resting metabolic rate to refine energy expenditure measures. These multiple measurements will allow an evaluation of the error structure associated with dietary and physical activity assessment methods, in particular the influences of variation over time for each method and correlated errors between methods. This will provide information of the relative and absolute validity of the different measures, and inform the interpretation of the published literature on diet and cancer (allowing for measurement error correction) and the design of future validation/calibration studies. Additional analyses will indicate the optimal approaches to adjust nutrient intakes for total energy intake, which is critical for the interpretation of epidemiologic findings. PUBLIC HEALTH RELEVANCE: The proposed validation/calibration study will provide quantitative data on the validity of the methods that have been used in cohort studies to measure diet and physical activity. This information would greatly enhance the value of the data that have been collected and would also provide invaluable guidance for the design and collection of future data on diet and physical activity and cancer by other investigators, resulting in great benefit to public health.

描述(由申请人提供)：关于饮食和癌症的大型前瞻性研究往往不支持基于动物和生态发现的假设；一个可能的解释是饮食评估中的巨大测量误差。因此，NCI征求了一系列合作验证/校准研究的建议，这些研究嵌入在现有的队列中，使用共同的设计，包括饮食和体力活动的多个自我报告和生物标记物测量，包括双标记水(DLW)、尿氮(UN)和运动监测器。因此，我们建议对750名男性进行这样一项研究。这项拟议的研究将补充NCI资助的一项非常类似的研究，该研究在护士健康研究的参与者中使用许多相同的方法。这两项研究将提供实质性的协同作用。在这项拟议的研究中，375名男性将参与正在进行的卫生专业人员后续研究(HPFS)，由于已经收集了丰富的数据，这项研究将具有特别的价值。其他375名参与者将从波士顿地区的卫生保健组织哈佛朝圣者健康护理中心抽出。这一参与者池将允许更广泛的社区代表性，对非裔美国人进行过度抽样，并有可能与临床数据库建立联系。在HPFS，我们已经使用多种饮食摄入量和血浆生物标记物收集了广泛的饮食数据；这将使我们能够在23年期间评估饮食评估方法的有效性。拟议的研究设计将包括两个相隔一年的FFQ；在这些措施之间的一年中，我们将收集四个NCI自动24小时自我管理召回(ASA24)、两个7天饮食记录和饮食生物标记物，包括一个使用双标记水(DLW)的能量消耗评估，四个24小时尿氮(蛋白质摄入量的衡量标准)，钠和钾的测量，以及两个用于评估脂肪酸、标准血脂、类胡萝卜素和叶酸的空腹血液样本。体力活动将通过修改后的Paffenbarger体力活动问卷进行两次评估(与FFQ一起)，通过使用NCI开发的自动化系统进行四次24小时召回，通过客观体力活动监测器和DLW进行两次评估。在来自波士顿地区的575名男性(来自HPFS和HMO)中，我们还将评估DEXA和静息代谢率，以完善能量消耗指标。这些多重测量将允许评估与饮食和体力活动评估方法有关的误差结构，特别是每种方法随时间变化的影响以及方法之间的相关误差。这将提供不同措施的相对和绝对有效性的信息，并为关于饮食与癌症(允许测量误差校正)的已发表文献的解释和未来验证/校准研究的设计提供信息。其他分析将指出调整总能量摄入量的营养摄入量的最佳方法，这对解释流行病学结果至关重要。 公共卫生相关性：拟议的验证/校准研究将提供定量数据，说明队列研究中用于测量饮食和体力活动的方法的有效性。这些信息将大大提高已经收集的数据的价值，并将为其他调查人员设计和收集未来关于饮食和体力活动与癌症的数据提供宝贵的指导，从而对公众健康产生巨大的好处。