Cohort Follow-up and Database Maintenance

队列随访和数据库维护核心（核心C）作为数据中心 处理、队列维护、癌症文件和卫生部生物标本储存库 专业人士的后续研究，因此，它支持本提案中的每个项目。的目标 核心是：（1）制定和邮寄后续调查问卷，（2）处理、核实和汇编数据库， 接触数据，（3）记录癌症事件报告，（4）查明和确定死亡原因 在所有参与者中，（5）追踪丢失的主题并维护姓名和地址文件，以及（6）维护 通过两年期通讯和通信参与。核心也是所有四个人的资源 这些项目使用了存储的问卷数据，来自18，018名男性的血浆和血沉棕黄层，来自一名男性的脸颊细胞， 另外17，000名男性，以及从2，000多例确诊的癌症和腺瘤病例中收集的肿瘤块。 在其他研究人员对该计划项目的投入下，核心C开发和设计了两年一度的后续计划。 向研究参与者发送调查问卷，以更新有关饮食、暴露信息、身体状况、 活动和重大疾病。在保持与以往调查表的连续性的同时， 还对假设进行评估，并仔细审查问题的具体措辞。收回的调查表 检查完整性、光学扫描、验证扫描错误、数字成像、存储，然后 编制了暴露信息数据库。Core C使用多种方法来跟踪参与者， 保持高水平的参与。对于每个两年的随访周期，我们的平均应答率为93%。 目前，超过71%的参与者仅通过一次邮寄就对2004年的调查表作出了答复。从 收集到的信息，通过获取医疗记录，记录癌症的发病病例。我们 据估计，我们将需要在未来5年内确认超过5000例腺瘤和癌症病例， 书房大多数死亡是通过邮寄问卷和搜索全国死亡调查表报告的。 每两年一次的问卷调查周期结束后进行索引。这项研究的另一个主要组成部分是 通过收集生物标本。已经制定了有效的程序， 用于流行和偶发结肠息肉、结肠癌和前列腺癌病例的病理学块。芯C 作为使用储存标本的项目的资源。

The Cohort Follow-up and Database Maintenance core (Core C) serves as the center for data processing, cohort maintenance, cancer documentation, and biospecimen repository for the Health Professionals Follow-up Study, and, thus, it supports each of the projects within this proposal. The goals of the core are to: (1) develop and mail follow-up questionnaires, (2) process, verify and compile a database of exposure data, (3) document reports of incident cases of cancer, (4) identify and ascertain cause of death among all participants, (5) trace lost subjects and maintain a name and address file, and (6) maintain participation through biennial newsletters and correspondence. The core also serves as a resource to all four projects which use stored questionnaire data, plasma and buffy coat from 18,018 men, cheek cells from an additional 17,000 men, and tumor blocks collected from over 2,000 confirmed cancer and adenoma cases. With input from other investigators on the Program Project, Core C develops and designs the biennial follow- up questionnaire sent to study participants to update information on diet, exposure information, physical activity, and major illnesses. While maintaining continuity with previous questionnaires, new and existing hypotheses are also evaluated and specific wording for questions is scrutinized. Returned questionnaires are checked for completeness, optically scanned, verified for scanning errors, digitally imaged, stored, and a database of exposure information is compiled. Core C uses a variety of methods to trace participants and to maintain high levels of participation. For each two-year follow-up cycle, we average a 93% response rate. At present, over 71% of participants responded to the 2004 questionnaire after only a single mailing. From the information collected, incident cases of cancer are documented by obtaining medical records. We estimate that we will need to confirm more than 5000 adenoma and cancer cases over the next 5 years of the study. Most deaths are reported through the questionnaire mailings, and searches of the National Death Index are done after each 2-year questionnaire cycle. A major additional component of the study has come through the collection of biological specimens. Efficient procedures have been developed to obtain pathology blocks for prevalent and incident colon polyps, colon cancer, and prostate cancer cases. Core C serves as a resource to projects which use stored specimens.