NEURAL CORRELATES OF AGE RELATED DIFFERENCES IN MEMORY

年龄相关记忆差异的神经关联

• 批准号: 2682106
• 负责人: NAFTALI RAZ
• 金额: $ 27.46万
• 依托单位: UNIVERSITY OF MEMPHIS
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2682106
• 关键词: adult human (21+); age difference; aging; brain mapping; cerebrum; clinical research; cognition; hippocampus; human old age (65+); human subject; intelligence tests; longitudinal human study; magnetic resonance imaging; mathematical model; memory; memory disorders; neural degeneration; neuroanatomy; neuropsychological tests; prefrontal lobe /cortex

DESCRIPTION: These studies extend and expand those conduct previously. These previous studies showed that age-related los in vortical volume is not uniform but differential and selective. Age-related loss in the prefrontal cortex if pronounced and associated with age-related deficits in executive functions. In contrast, age-related loss in the hippocampal formation is mild and not generally associated with memory deficits. In a subgroup of elderly adults, however, there was a significant association between hippocampal volume and explicit memory. It is hypothesized that prefrontal atrophy is associated with healthy aging, whereas limbic atrophy is associated with the beginning of cognitive pathology. The proposed studies have three goals: 1) Investigate the longitudinal course of cerebral and cognitive aging: 2) Expand the study of the relation between age-related atrophy in the prefrontal cortex and age-related decline in executive functions; and 3) Examine more closely the relation between age-related hippocampal atrophy and deficits in declarative memory after 60 years of age.

描述：这些研究以前扩展并扩展了这些行为。 这些先前的研究表明，与年龄相关的LOS涡流相关的LO为 不是统一的，而是差异和选择性。与年龄有关的损失 前额叶皮层如果发音并与年龄相关的缺陷有关 在执行功能中。相反，海马与年龄有关的损失 形成是温和的，通常与记忆缺陷无关。在 但是，成年人的亚组有很大的关联 在海马体积和明确的内存之间。假设 前额叶萎缩与健康衰老有关，而边缘则 萎缩与认知病理学的开始有关。这 拟议的研究有三个目标：1）调查纵向过程 大脑和认知衰老的衰老：2）扩大关系的研究 在前额叶皮层中与年龄有关的萎缩与年龄有关 行政职能下降； 3）更仔细地检查关系 与年龄有关的海马萎缩与声明性记忆中的缺陷之间 60岁以后。