NEURAL CORRELATES OF AGE RELATED DIFFERENCES IN MEMORY

年龄相关记忆差异的神经关联

• 批准号: 2682106
• 负责人: NAFTALI RAZ
• 金额: $ 27.46万
• 依托单位: UNIVERSITY OF MEMPHIS
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2682106
• 关键词: adult human (21+); age difference; aging; brain mapping; cerebrum; clinical research; cognition; hippocampus; human old age (65+); human subject; intelligence tests; longitudinal human study; magnetic resonance imaging; mathematical model; memory; memory disorders; neural degeneration; neuroanatomy; neuropsychological tests; prefrontal lobe /cortex

DESCRIPTION: These studies extend and expand those conduct previously. These previous studies showed that age-related los in vortical volume is not uniform but differential and selective. Age-related loss in the prefrontal cortex if pronounced and associated with age-related deficits in executive functions. In contrast, age-related loss in the hippocampal formation is mild and not generally associated with memory deficits. In a subgroup of elderly adults, however, there was a significant association between hippocampal volume and explicit memory. It is hypothesized that prefrontal atrophy is associated with healthy aging, whereas limbic atrophy is associated with the beginning of cognitive pathology. The proposed studies have three goals: 1) Investigate the longitudinal course of cerebral and cognitive aging: 2) Expand the study of the relation between age-related atrophy in the prefrontal cortex and age-related decline in executive functions; and 3) Examine more closely the relation between age-related hippocampal atrophy and deficits in declarative memory after 60 years of age.

描述：这些研究扩展和扩展了以前的研究。 这些先前的研究表明，与年龄有关的涡量损失是 不是统一的，而是有差别的、有选择的。1999年与索赔有关的损失 前额皮质，如果明显且与年龄相关的缺陷相关 执行功能。与此相反，海马神经元中与年龄相关的损失 形成是温和的，通常与记忆缺陷无关。中 然而，在老年人的一个亚组中， 海马体积和外显记忆之间的联系它是假设 前额叶萎缩与健康老龄化有关，而边缘系统 萎缩与认知病理学的开始有关。的 本研究有三个目标：1）研究纵向过程 2）扩大对大脑和认知老化之间关系的研究 与年龄相关的前额皮质萎缩和 执行功能下降; 3）更密切地检查 与年龄相关的海马萎缩和陈述性记忆缺陷之间的联系 60岁以后。