NEURAL CORRELATES OF AGE RELATED DIFFERENCES IN MEMORY

年龄相关记忆差异的神经关联

• 批准号: 6371803
• 负责人: NAFTALI RAZ
• 金额: $ 5.67万
• 依托单位: UNIVERSITY OF MEMPHIS
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6371803
• 关键词: adult human (21+); age difference; aging; brain mapping; cerebrum; clinical research; cognition; hippocampus; human old age (65+); human subject; intelligence tests; longitudinal human study; magnetic resonance imaging; mathematical model; memory; memory disorders; neural degeneration; neuroanatomy; neuropsychological tests; prefrontal lobe /cortex

DESCRIPTION: These studies extend and expand those conduct previously. These previous studies showed that age-related los in vortical volume is not uniform but differential and selective. Age-related loss in the prefrontal cortex if pronounced and associated with age-related deficits in executive functions. In contrast, age-related loss in the hippocampal formation is mild and not generally associated with memory deficits. In a subgroup of elderly adults, however, there was a significant association between hippocampal volume and explicit memory. It is hypothesized that prefrontal atrophy is associated with healthy aging, whereas limbic atrophy is associated with the beginning of cognitive pathology. The proposed studies have three goals: 1) Investigate the longitudinal course of cerebral and cognitive aging: 2) Expand the study of the relation between age-related atrophy in the prefrontal cortex and age-related decline in executive functions; and 3) Examine more closely the relation between age-related hippocampal atrophy and deficits in declarative memory after 60 years of age.

描述：这些研究延伸和扩展了以前的研究。 这些先前的研究表明，与年龄相关的涡量损失是 不是统一的，而是有区别的和有选择性的。与年龄相关的损失在 前额叶皮质是否发音并与年龄相关的缺陷有关 在执行职能方面。相比之下，与年龄相关的海马区丢失 形成是温和的，通常与记忆缺陷无关。在一个 然而，老年人的亚组中，有一个显著的关联 在海马体体积和外显记忆之间。据推测， 前额叶萎缩与健康衰老有关，而边缘 萎缩与认知病理的开始有关。这个 建议的研究有三个目标：1)调查纵向过程 脑老化与认知老化的研究：2)拓展脑老化与认知老化关系的研究 前额叶皮质的年龄相关性萎缩和年龄相关性之间的关系 行政职能的下降；以及3)更密切地审视两者的关系 年龄相关性海马区萎缩与陈述性记忆障碍之间的关系 60岁以后。