CHRONIC PROSTATITIS COLLABORATIVE CLINICAL RESEARCH STUD

慢性前列腺炎合作临床研究

• 批准号: 2770689
• 负责人: MARK S. LITWIN
• 金额: $ 29.47万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2770689
• 关键词: behavioral /social science research tag; biomarker; cellular immunity; clinical research; diagnosis design /evaluation; enzyme activity; fluorescent in situ hybridization; human subject; leukocyte activation /transformation; leukocyte count; leukocytes; nitric oxide synthase; outcomes research; pathologic process; prostate; prostatitis; psychometrics; quality of life; questionnaires; secretion; sign /symptom; urinary tract disorder chemotherapy; urinary tract disorder diagnosis

DESCRIPTION (Taken from the applicant's Abstract) Chronic non-infectious prostatitis or chronic pelvic pain syndrome (CPPS) represents one of the greatest challenges in clinical medicine. It consists of a constellation of symptoms that are subjectively evaluated by both the patient and his physician. These may include perineal and thigh pain, penile discomfort, orchalgia, lower back pain, irritative and obstructive voiding symptoms, ejaculatory dysfunction, fatigue, and a variety of other complaints. Treatments often lead to minimal or intermittent improvement, frequent exacerbations, increasing frustration, and extensive utilization of resources. In CPPS, physicians and researchers lack a clear understanding of the relevant pathophysiology and immunology, lack consensus on what constitutes the appropriate diagnostic evaluation and therapeutic management, and disagree on how best to quantify patients' symptoms and the resulting quality of life impact. The goal of this proposal is to carry out two specific projects that address current knowledge deficits in CPPS. The first involves the development and validation of a symptom index and a quality of life impact index for men with CPPS. The multi-center nature of the project will allow for the creation of an instrument that is psychometrically reliable and valid yet easily understood and completed by patients. With a uniformly accepted outcome measure, researchers and clinicians can begin speaking the same language when assessing the natural history of this disease and its response to various proposed treatments. The second is to determine whether CPPS is an inappropriate injury response in the absence of ongoing bacterial injury. It will establish signal modulators that provide novel and effective tools to diagnose CPPS and to select and monitor treatment efficacy for individual patients. We will study the biochemical, cellular and molecular markers from the fluid and cells of expressed prostatic secretions and correlate these parameters with the outcomes measures developed in the first project. The biological measures will include quantification of white blood cells, nitric oxide activity in prostatic fluid, and fluorescent in situ hybridization of prostate fluid cells for markers of individual immune cell types and immune cell activation.

描述（摘自申请人的摘要） 慢性非感染性前列腺炎或慢性盆腔疼痛综合征（CPPS） 是临床医学面临的最大挑战之一。 它包括 由双方主观评估的一系列症状 病人和他的医生。 这些可能包括会阴和大腿疼痛， 阴茎不适、睾丸痛、腰痛、刺激性和阻塞性 排尿症状、射精功能障碍、疲劳和各种其他症状 投诉。 治疗通常会带来最小的或间歇性的改善， 频繁恶化、不断增加的挫败感以及广泛使用 资源。 对于CPPS，医生和研究人员缺乏清晰的认识 相关病理生理学和免疫学的研究缺乏共识 构成适当的诊断评估和治疗 管理，并且在如何最好地量化患者的症状和治疗方面存在分歧 由此产生的生活质量影响。 该提案的目标是执行 两个解决 CPPS 当前知识缺陷的具体项目。 第一个涉及症状指数和症状指数的开发和验证 CPPS 男性的生活质量影响指数。 多中心性质 该项目将允许创建一个工具 心理测量可靠且有效，但易于理解和完成 患者。 通过统一接受的结果衡量标准，研究人员和 临床医生在评估自然情况时可以开始使用相同的语言 这种疾病的病史及其对各种拟议治疗的反应。 二是确定CPPS是否属于不适当的损伤反应 在没有持续的细菌损伤的情况下。 它将建立信号 调节器提供新颖有效的工具来诊断 CPPS 并 选择并监测个体患者的治疗效果。 我们将 研究液体中的生化、细胞和分子标记， 表达前列腺分泌物的细胞并将这些参数与 第一个项目中制定的成果衡量标准。 生物的 措施将包括白细胞、一氧化氮的量化 前列腺液中的活性，以及​​荧光原位杂交 前列腺液细胞作为个体免疫细胞类型和免疫标记物 细胞激活。