CHRONIC PROSTATITIS COLLABORATIVE CLINICAL RESEARCH

慢性前列腺炎合作临床研究

• 批准号: 2770685
• 负责人: ANTHONY J SCHAEFFER
• 金额: $ 30.71万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2770685
• 关键词: biofeedback; biopsy; chronic disease /disorder; clinical research; cooperative study; cytokine; diagnosis design /evaluation; disease /disorder etiology; human subject; human therapy evaluation; male; microorganism culture; molecular pathology; outcomes research; pain; polymerase chain reaction; prostatitis; urination

DESCRIPTION (Taken from the applicant's Abstract) Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CPPS) affects men of all ages. Cytokines are important inflammatory mediators. We have shown a direct significant correlation between the levels of interleukin-1-beta (IL-1-beta) and white blood cells. Furthermore IL-1-beta levels were significantly higher in expressed prostatic secretion (EPS) of men with inflammatory CPPS than in controls. The specific aims are to investigate: 1. Cytokines in CPPS. We will test the hypothesis that cytokines are important in CPPS by measuring IL-1-beta, TNF-alfa (tumor necrosis factor-alpha), IL-6, and IL-8 in EPS and prostate tissue collected from 150 men with CPPS. We will correlate cytokine levels, symptoms, urodynamic findings, and response to behavioral modification and utilization, to classify patients and to determine the role of anticytokine therapy. 2. Infectious agents and CPPS. We will test the hypothesis that infectious agents are important in CPPS using rRNA probes and polymerase chain reaction (PCR) to search for the presence of fastidious bacteria and viruses in prostate biopsy specimens from men with CPPS. We will determine whether the organisms associated with inflammatory CPPS differ from those associated with noninflammatory CPPS and correlate these finding with the presence of cytokines. These findings will provide important new insights into the pathogenesis of CPPS and allow the development of potential antimicrobial therapy for CPPS. 3. Voiding Dysfunction/Biofeedback and CPPS. We will test the hypothesis that men with CPPS have dysfunctional voiding and that symptoms can be improved through biofeedback. Men will be randomized to biofeedback or no biofeedback. This study will provide insight into relationships between CPPS, the clinical indications for urodynamics in evaluating patients, and response to behavioral modification in these patients. 4a. Effectiveness of biofeedback treatment. We will test the hypothesis that patients who receive biofeedback treatment will have better outcomes as measured by health status, a reduction in symptoms or an improvement in functional status, an improvement of quality of life, and a reduction in healthcare utilization as measured by visits, tests, and contacts. diagnostic, management, and treatment pathways for cost-effective care for men with CPPS. This project will provide important new insights into the pathogenesis and management of men with CPPS.

描述（摘自申请人摘要） 慢性前列腺炎/慢性盆腔疼痛综合征（CPPS）影响所有男性 年龄 细胞因子是重要的炎症介质。 我们展示了一个 白细胞介素-1-β的水平之间的直接显着相关性 （IL-1-β）和白色血细胞。 此外，IL-1-β水平 前列腺液（EPS）的男性显着高于 炎症性CPPS。 具体目标是调查： 1. CPPS中的细胞因子。 我们将检验细胞因子是 通过测量IL-1-β、TNF-α（肿瘤坏死 从150例患者中收集的EPS和前列腺组织中的IL-6和IL-8 有CPPS的人 我们会将细胞因子水平症状尿动力学 研究结果，以及对行为改变和利用的反应， 对患者进行分类并确定抗细胞因子治疗的作用。 2. 传染性病原体和CPPS。 我们将检验这个假设， 感染因子在使用rRNA探针和聚合酶的CPPS中是重要的 链反应（PCR），以寻找苛养菌的存在， CPPS患者前列腺活检标本中的病毒。 我们将确定 与炎症性CPPS相关的微生物是否与那些 与非炎症性CPPS相关，并将这些发现与 细胞因子的存在。 这些发现将提供重要的新见解 研究CPPS的发病机制， CPPS的抗菌治疗。 3. 排尿功能障碍/生物反馈和CPPS。 我们将测试 假设CPPS患者排尿功能障碍， 可以通过生物反馈来改善。 男性将被随机分配到生物反馈组 或者没有生物反馈 这项研究将提供洞察关系 在CPPS中，尿动力学的临床指征在评价 患者，以及对这些患者行为改变的反应。 4a. 生物反馈治疗的效果。 我们将检验这个假设 接受生物反馈治疗的患者会有更好的结果， 以健康状况、症状减轻或 功能状态，生活质量的改善， 通过访问、测试和接触测量的医疗保健利用率。 诊断、管理和治疗途径，以提供具有成本效益的护理， 有CPPS的人 该项目将提供重要的新见解的发病机制， 管理CPPS患者。