FHS--MOLECULAR GENETICS LABORATORY

FHS--分子遗传学实验室

• 批准号: 2750560
• 负责人: MARK LEPPERT
• 金额: $ 48.91万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-15 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2750560
• 关键词: African American; atherosclerosis; biomedical facility; cardiovascular disorder epidemiology; clinical research; cooperative study; coronary disorder; family genetics; gene frequency; genetic mapping; genetic markers; human data; human genetic material tag; human population genetics; molecular genetics

DESCRIPTION (Adapted from the applicants' abstract) FHS: Molecular Genetics and Genetic Epidemiology is submitted collaboratively by seven research groups including four clinical sites (University of North Carolina; Boston University; University of Minnesota; and University of Utah), a molecular biology laboratory (University of Utah), a coordinating center (Washington University, St. Louis, MO), a chemistry laboratory (University of Minnesota). The proposed study will perform state-of-the-art molecular genetic and genetic epidemiology studies using the extensive data on family and medical histories, risk factors, life style, blood specimens and banked DNA, previously collected by the Family Heart Study (FHS). The purpose is to identify and characterize genes of coronary heart disease (CHD) and atherosclerosis, familial environmental factors and behavioral characteristics, and to advance our understanding of how they interact with one another in the development of clinical outcomes.

描述(摘自申请者的摘要)FHS：分子遗传学 基因流行病学由七项研究合作提交 小组包括四个临床站点(北卡罗来纳大学；波士顿 明尼苏达大学和犹他大学)，一种分子 生物实验室(犹他大学)，协调中心(华盛顿 密苏里州圣路易斯大学)，一个化学实验室(密苏里州圣路易斯大学 明尼苏达州)。这项拟议的研究将执行最先进的分子 利用广泛的家庭数据进行遗传和遗传流行病学研究 和病史，危险因素，生活方式，血液样本和银行 DNA，之前由家庭心脏研究(FHS)收集。其目的是 鉴定和鉴定冠心病(CHD)基因和 动脉粥样硬化、家族性环境因素与行为 特征，并增进我们对它们如何与 在临床结果的发展中相互作用。