Research Training in Inherited Neurological Disease

描述(由申请人提供) 这是一份修订后的拨款申请，用于创建一个研究项目 犹他大学的遗传性神经疾病培训。十九 教职员工是学员的研究导师，教职员工 由内科科学家和基础科学家组成。研究小组 参加培训计划的包括神经肌肉科(科室) 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--文摘内容儿科)；以及 人类遗传学，神经生物学和解剖学，以及眼科。 所代表的领域包括运动障碍的遗传学、 脱髓鞘障碍，病毒介导的基因转移的研究，以及 通过同源重组进行靶向基因破坏。研究 实习生的机会包括接触大家庭以建立联系 测绘和基因/表型相关性研究，以及接触现代 分子生物学、遗传流行病学、连锁分析和 基因组分析。 提出了一个高度集中的两年博士后培训计划。 课程，作为第一年的教学课程的一部分，将 为受训人员提供必要的背景知识和知识基础 临床研究。此应用程序请求支持一个 医生-科学家博士后第一年实习生，以及两个实习生 在接下来的每一年。此外，为回应《 之前的审查，为两名博士前候选人申请了资金支持 每年，以竞争性方式从大学的 多学科神经科学和分子生物学课程。

DESCRIPTION (provided by applicant) This is a revised application for a grant to create a program in Research Training in Inherited Neurologic Diseases at the University of Utah. Nineteen faculty members serve as research preceptors for trainees, and the faculty consists of both physician-scientists and basic scientists. Research groups participating in the Training Program include the Neuromuscular Division (Dept. of Neurology); the Division of Medical Genetics (Dept. of Pediatrics); and the Departments of Human Genetics, Neurobiology and Anatomy, and Ophthalmology. Areas represented include genetics of movement disorders, genetics of demyelinating disorders, studies of virally-mediated gene transfer, and targeted gene disruption through homologous recombination. Research opportunities for trainees include exposure to large kindreds for linkage mapping and genotype/phenotype correlation studies, and exposure to modern techniques of molecular biology, genetic epidemiology, linkage analysis, and genomic analysis. A plan is presented for a highly focused two-year postdoctoral training program, with a didactic curriculum as part of the first year which will provide the trainee with the necessary background and knowledge base for clinical research. This application requests support for one physician-scientist post-doctoral trainee in the first year, and two trainees in each of the subsequent years. In addition, in response to comments in the previous review, funding support is requested for two predoctoral candidates per year, to be competitively selected from trainees within the University's multidisciplinary Neuroscience and Molecular Biology programs.