Research Training in Inherited Neurological Disease

描述（由申请人提供） 这是一份修改后的申请，用于创建一个研究项目 在犹他州大学接受遗传性神经疾病培训。十九 教师担任研究导师的学员，和教师 由物理科学家和基础科学家组成。研究小组 参加培训计划的包括神经肌肉科（部门）。 神经病学）;医学遗传学部（部。儿科）;以及 人类遗传学系、神经生物学系、解剖学系和眼科学系。 代表的领域包括运动障碍的遗传学， 脱髓鞘疾病，病毒介导的基因转移的研究， 通过同源重组进行靶向基因破坏。研究 受训人员的机会包括接触大型Kinematic， 定位和基因型/表型相关性研究，以及暴露于现代 分子生物学技术，遗传流行病学，连锁分析， 基因组分析 提出了一个为期两年的高度集中的博士后培养计划 计划，与教学课程的一部分，第一年将 为学员提供必要的背景和知识基础， 临床研究此应用程序请求支持一个 第一年有一名医生-科学家博士后实习生， 在随后的每一年。此外，针对《公约》中的评论， 前审查，资金支持是两个博士候选人的要求 每年，将从大学的 多学科神经科学和分子生物学课程。

DESCRIPTION (provided by applicant) This is a revised application for a grant to create a program in Research Training in Inherited Neurologic Diseases at the University of Utah. Nineteen faculty members serve as research preceptors for trainees, and the faculty consists of both physician-scientists and basic scientists. Research groups participating in the Training Program include the Neuromuscular Division (Dept. of Neurology); the Division of Medical Genetics (Dept. of Pediatrics); and the Departments of Human Genetics, Neurobiology and Anatomy, and Ophthalmology. Areas represented include genetics of movement disorders, genetics of demyelinating disorders, studies of virally-mediated gene transfer, and targeted gene disruption through homologous recombination. Research opportunities for trainees include exposure to large kindreds for linkage mapping and genotype/phenotype correlation studies, and exposure to modern techniques of molecular biology, genetic epidemiology, linkage analysis, and genomic analysis. A plan is presented for a highly focused two-year postdoctoral training program, with a didactic curriculum as part of the first year which will provide the trainee with the necessary background and knowledge base for clinical research. This application requests support for one physician-scientist post-doctoral trainee in the first year, and two trainees in each of the subsequent years. In addition, in response to comments in the previous review, funding support is requested for two predoctoral candidates per year, to be competitively selected from trainees within the University's multidisciplinary Neuroscience and Molecular Biology programs.