CHILDREN'S CANCER GROUP

儿童癌症组

• 批准号: 2607960
• 负责人: Joseph P Neglia
• 金额: $ 39.1万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2607960
• 关键词: Ewing's tumor; Wilms' tumor; acute lymphocytic leukemia; acute myelogenous leukemia; antineoplastics; biological response modifiers; bone marrow transplantation; child (0-11); clinical trials; combination cancer therapy; combination chemotherapy; cooperative study; human subject; human therapy evaluation; longitudinal human study; neoplasm /cancer chemotherapy; neoplasm /cancer epidemiology; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; osteosarcoma; pediatric neoplasm /cancer; pharmacokinetics; retinoblastoma; tumor antigens

This grant is aimed at facilitating the continued involvement of investigators at the University of Minnesota in the multi-institutional cooperative therapeutic and non-therapeutic studies conducted by the Childrens Cancer Group (CCG). During the past five years, the University of Minnesota has maintained its role as a leading institution in CCG, both logistically and scientifically. Since 1983, there has been a 50% increase in the number of patients placed on study by the University of Minnesota network such that by 1992 over 125 new patients are expected on 1st line studies and 1,117 patients will be in active follow-up, placing the University of Minnesota third among CCG's 33 principal institutions in both categories. Scientifically, the University of Minnesota investigators have been leaders in various aspects of CCG studies, including treatment of acute lymphocytic leukemia, acute myeloid leukemia, and neuroblastoma; investigation of new agents and pharmacokinetics of anti-cancer drugs; bone marrow transplantation for leukemia, neuroblastoma, and other childhood solid tumors; radiation therapy, including total body irradiation; characterization of cancer cells, including cytogenetics and cell surface antigen determinations; cancer epidemiology; and studies investigating the late effects of childhood cancer and its treatment. Twenty-one University of Minnesota investigators hold positions on CCG study committees, strategy groups, scientific committees, discipline committees, or administrative committees. Furthermore, 15 of these investigators have been chairpersons of various CCG committees, documenting that the University of Minnesota is among the top CCG institutions in scientific leadership. CCG studies are conducted using a "team approach" which involves individuals from a wide range of disciplines including oncologists, radiation therapists, surgeons, immunologists, pathologists, cytogeneticists, pharmacologists, and epidemiologists. University of Minnesota investigators are involved in virtually all areas of CCG interest and our involvement in future CCG studies will continue to grow. This grant requests personnel support for Minnesota investigators and personnel key to the maintenance of effective data management and quality control for CCG studies; travel for Minnesota investigators; and miscellaneous expenses for administering our continued involvement in both scientific input and the direction, planning, development, and conduct of clinical investigation and ancillary studies to be conducted by the Childrens Cancer Group.

这笔赠款旨在促进继续参与 明尼苏达大学的多机构研究人员 由以下机构进行的合作治疗性和非治疗性研究 儿童癌症小组 (CCG)。过去五年，大学 明尼苏达大学一直保持其作为 CCG 领先机构的地位， 逻辑上和科学上。自1983年以来，增长了50% 明尼苏达大学安排进行研究的患者数量 到 1992 年，第一线预计将有超过 125 名新患者 研究将对 1,117 名患者进行积极随访，将 明尼苏达大学在 CCG 的 33 所主要院校中排名第三 两个类别。从科学角度来说，明尼苏达大学的研究人员 一直是 CCG 研究各个方面的领导者，包括治疗 急性淋巴细胞白血病、急性髓细胞白血病和神经母细胞瘤； 抗癌药物新药及药代动力学研究； 骨髓移植治疗白血病、神经母细胞瘤等 儿童实体瘤；放射治疗，包括全身 辐照；癌细胞的特征，包括细胞遗传学和 细胞表面抗原测定；癌症流行病学；和研究 研究儿童癌症的晚期影响及其治疗。 21 名明尼苏达大学调查员在 CCG 上任职 研究委员会、战略小组、科学委员会、学科 委员会，或行政委员会。此外，其中 15 个 调查人员曾担任多个 CCG 委员会的主席， 记录明尼苏达大学跻身顶尖 CCG 之列 科学领导机构。 CCG 研究是使用 “团队方法”，涉及来自广泛领域的个人 学科包括肿瘤科医生、放射治疗师、外科医生、 免疫学家、病理学家、细胞遗传学家、药理学家和 流行病学家。明尼苏达大学调查人员参与 几乎所有 CCG 感兴趣的领域以及我们未来 CCG 的参与 研究将继续增长。此项拨款要求人员支持 明尼苏达州的调查人员和人员对于维持有效的调查至关重要 CCG 研究的数据管理和质量控制；明尼苏达州旅行 调查员；以及管理我们持续的杂项费用 参与科学投入和指导、规划、 临床调查和辅助研究的开发和实施 由儿童癌症小组进行。