Bedside to Bench and Back Again: Training Pediatricians in Translational Research

描述（由申请人提供）：本提案旨在明尼苏达大学（UM）医学院儿科系设立儿童健康研究职业发展奖。我们的长期目标是促进从事与儿童健康相关的基础和转化研究的医生调查人员的职业发展。UM在儿童健康研究方面有着悠久而丰富的历史，在获得NIH资助方面一直名列全国前20名。UM也有与业界建立伙伴关系的历史，将学术医学开发的创新技术提供给儿童的床边。儿科系目前正处于一个动态的增长阶段，在教师的显着扩张和一个新的儿童医院在UM校园的建设驱动。内部资助计划已经成功地为助理教授提供了指导性的学术培训，重点是UM指定的五个高优先级研究领域作为“研究走廊”：癌症，糖尿病，传染病，心血管健康和大脑疾病。这些努力产生了NIH资助的儿科研究人员，并在培训妇女方面取得了特别成功。为了满足学术儿科科学家在这里和其他地方的未来需求，我们目前的目标是通过资助2 CHRCDA学者/年扩大我们的培训计划的影响。儿科系保证为学者提供整整三年的75%受保护时间。一个强大的指导团队将致力于以下的学者CHRCDA培训完成后，在整个6-9年期间作为助理教授，直到晋升。该计划致力于吸引致力于学术医学的个人，提供科学丰富的环境，为儿科医生提供在发育生物学，遗传学，分子生物学，细胞生物学和转化研究方面拥有专业知识的成熟实验室进行培训的机会。除了20 NIH资助的儿科或附属导师（其中5人本身是R 01资助的前CHRCDA学者）部门，额外的计划教师将从不同的领域和部门在UM选择。外部和内部咨询委员会将定期监测该计划的进展情况。考虑到可用的教师，设施，课程和行政结构，正式的选择和评估过程，以及在招聘和整个培训期间的期望，该培训计划预计将使儿科的UM部门大大扩展现有的计划，我们的目标是继续保持我们在培养独立调查人员进行尖端儿童健康研究方面的良好记录。 公共卫生相关性：儿童疾病继续在全球造成重大痛苦和死亡。此外，许多成人疾病始于儿童时期，因此投资于儿科医学的生物医学研究是确保个人一生健康的一个重要目标。迫切需要产生关于儿童疾病的新知识，并将基本研究成果转化为更有效的疾病控制干预措施，以改善儿童和成人的健康。一群具有广泛研究专业知识的经验丰富的导师将教育从事学术医学职业的儿科医生如何进行对儿童健康重要的基础和转化研究，以提高我们对儿科疾病的理解和发现新疗法的目标。

DESCRIPTION (provided by applicant): This proposal seeks to establish a Child Health Research Career Development Award in the Department of Pediatrics at the University of Minnesota (UM) Medical School. Our long-term goal is to foster the career development of physician-investigators engaged in basic and translational research relevant to the health of children. UM has a long and rich history of child health research, consistently ranking in the top 20 nationally in securing funding from the NIH. UM also has a history of forging partnerships with industry to deliver innovative technologies developed in academic medicine to the bedside of children. The Department of Pediatrics is currently in a dynamic growth phase, driven by a significant expansion in faculty and the construction of a new children's hospital on the UM campus. Internal funding programs have been successful in providing mentored academic training for assistant professors, focused in five high-priority areas of research designated by the UM as "research corridors": cancer, diabetes, infectious diseases, cardiovascular health, and brain disorders. These efforts have produced NIH funded pediatric investigators, and have been particularly successful in training women. To meet future needs for academic pediatric scientists here and elsewhere, our current goal is to expand the impact of our training program by funding 2 CHRCDA Scholars/year. The Department of Pediatrics guarantees a full three years of 75% protected time for Scholars. A strong mentoring team will commit to following the Scholar after completion of CHRCDA training, throughout the 6-9 year period as an Assistant Professor, until promotion. This program strives to attract individuals with a commitment to academic medicine, providing a scientifically rich environment where pediatricians are afforded the opportunity of training in established laboratories with expertise in developmental biology, genetics, molecular biology, cell biology, and translational research. In addition to 20 NIH-funded Department of Pediatrics or affiliated mentors (5 of whom are themselves R01 funded former CHRCDA Scholars), additional program faculty will be chosen from diverse fields and departments at the UM. External and internal advisory committees will monitor progress of the program on a regular basis. Given the available faculty members, the facilities, the curricular and administrative structure, the formal selection and evaluation processes, and the expectations both at recruitment and throughout the training period, this training program is expected to enable the UM Department of Pediatrics to substantially expand existing programs, toward the goal of continuing our strong track record of producing independent investigators performing cutting-edge child health research. PUBLIC HEALTH RELEVANCE: Childhood diseases continue to cause significant suffering and death globally. In addition, many adult diseases have their beginnings in childhood, making investment in biomedical research in pediatric medicine an important goal for ensuring health throughout the lifetime of an individual. There is a critical need to generate new knowledge about childhood diseases, and translate basic research findings into more effective disease control interventions to improve the health of children and adults. A group of experienced mentors with extensive research expertise will educate pediatric physicians embarking on careers in academic medicine in how to conduct basic and translational research of importance to child health, toward the goals of improving our understanding of pediatric diseases and discovering novel therapies.