Bedside to Bench and Back Again: Training Pediatricians in Translational Research

描述(由申请人提供)：本提案寻求在明尼苏达大学医学院儿科设立儿童健康研究职业发展奖。我们的长期目标是促进从事与儿童健康相关的基础和转化性研究的医生-研究人员的职业发展。UM在儿童健康研究方面有着悠久而丰富的历史，在从NIH获得资金方面一直位居全国前20名。UM也有与业界建立合作伙伴关系的历史，以将学术医学开发的创新技术提供给儿童床边。儿科目前正处于一个动态的增长阶段，这是由教师的显著扩张和在密歇根大学校园内建造一所新的儿童医院推动的。内部资助项目成功地为助理教授提供了有指导的学术培训，重点放在密歇根大学指定的五个高度优先的研究领域：癌症、糖尿病、传染病、心血管健康和脑部疾病。这些努力产生了NIH资助的儿科研究人员，并在培训女性方面特别成功。为了满足这里和其他地方未来对学术儿科科学家的需求，我们目前的目标是通过资助2名CHRCDA学者/年来扩大我们培训计划的影响。儿科部门保证为学者提供整整三年75%的保护时间。一个强大的指导团队将致力于在完成CHRCDA培训后，在担任助理教授的6-9年期间跟踪该学者，直到晋升。该计划致力于吸引致力于学术医学的个人，提供一个科学丰富的环境，为儿科医生提供在具有发育生物学、遗传学、分子生物学、细胞生物学和转化研究专业知识的成熟实验室进行培训的机会。除了NIH资助的20名儿科或附属导师(其中5人本身就是R01资助的前CHRCDA学者)外，还将从UM的不同领域和部门挑选额外的项目教员。外部和内部咨询委员会将定期监测该方案的进展情况。考虑到现有的师资、设施、课程和行政结构、正式的遴选和评估过程，以及在招聘和整个培训期间的期望，这一培训计划有望使密歇根大学儿科系大幅扩展现有课程，朝着继续我们培养独立调查人员进行尖端儿童健康研究的良好记录的目标迈进。 公共卫生相关性：儿童疾病继续在全球造成重大痛苦和死亡。此外，许多成人疾病都始于儿童时期，这使得对儿科医学中的生物医学研究的投资成为确保个人一生健康的重要目标。迫切需要产生关于儿童疾病的新知识，并将基本研究成果转化为更有效的疾病控制干预措施，以改善儿童和成人的健康。一群具有广泛研究专业知识的经验丰富的导师将教育从事学术医学职业生涯的儿科医生如何进行对儿童健康重要的基础和转化性研究，以实现提高我们对儿科疾病的理解和发现新疗法的目标。

DESCRIPTION (provided by applicant): This proposal seeks to establish a Child Health Research Career Development Award in the Department of Pediatrics at the University of Minnesota (UM) Medical School. Our long-term goal is to foster the career development of physician-investigators engaged in basic and translational research relevant to the health of children. UM has a long and rich history of child health research, consistently ranking in the top 20 nationally in securing funding from the NIH. UM also has a history of forging partnerships with industry to deliver innovative technologies developed in academic medicine to the bedside of children. The Department of Pediatrics is currently in a dynamic growth phase, driven by a significant expansion in faculty and the construction of a new children's hospital on the UM campus. Internal funding programs have been successful in providing mentored academic training for assistant professors, focused in five high-priority areas of research designated by the UM as "research corridors": cancer, diabetes, infectious diseases, cardiovascular health, and brain disorders. These efforts have produced NIH funded pediatric investigators, and have been particularly successful in training women. To meet future needs for academic pediatric scientists here and elsewhere, our current goal is to expand the impact of our training program by funding 2 CHRCDA Scholars/year. The Department of Pediatrics guarantees a full three years of 75% protected time for Scholars. A strong mentoring team will commit to following the Scholar after completion of CHRCDA training, throughout the 6-9 year period as an Assistant Professor, until promotion. This program strives to attract individuals with a commitment to academic medicine, providing a scientifically rich environment where pediatricians are afforded the opportunity of training in established laboratories with expertise in developmental biology, genetics, molecular biology, cell biology, and translational research. In addition to 20 NIH-funded Department of Pediatrics or affiliated mentors (5 of whom are themselves R01 funded former CHRCDA Scholars), additional program faculty will be chosen from diverse fields and departments at the UM. External and internal advisory committees will monitor progress of the program on a regular basis. Given the available faculty members, the facilities, the curricular and administrative structure, the formal selection and evaluation processes, and the expectations both at recruitment and throughout the training period, this training program is expected to enable the UM Department of Pediatrics to substantially expand existing programs, toward the goal of continuing our strong track record of producing independent investigators performing cutting-edge child health research. PUBLIC HEALTH RELEVANCE: Childhood diseases continue to cause significant suffering and death globally. In addition, many adult diseases have their beginnings in childhood, making investment in biomedical research in pediatric medicine an important goal for ensuring health throughout the lifetime of an individual. There is a critical need to generate new knowledge about childhood diseases, and translate basic research findings into more effective disease control interventions to improve the health of children and adults. A group of experienced mentors with extensive research expertise will educate pediatric physicians embarking on careers in academic medicine in how to conduct basic and translational research of importance to child health, toward the goals of improving our understanding of pediatric diseases and discovering novel therapies.