SECOND MALIGNANT NEOPLASMS FOLLOWING CHILDHOOD LEUKEMIA
SECOND MALIGNANT NEOPLASMS FOLLOWING CHILDHOOD LEUKEMIA
批准号:
3079745
负责人:
Joseph P Neglia
金额:
$7.46万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-02-01 至 1992-01-31
关键词:
cancer registry /resource cancer risk child (0-11) drug related neoplasm /cancer embryo /fetus toxicology environment related neoplasm /cancer female fibroblasts human subject longitudinal human study lymphocytic leukemia neoplasm /cancer chemotherapy neoplasm /cancer genetics neoplasm /cancer radiation therapy neoplasm /cancer relapse /recurrence neuroblastoma patient /disease registry pediatric neoplasm /cancer perinatal radiation related neoplasm /cancer
中文摘要
急性淋巴细胞白血病(ALL)是最常见的
英文摘要
Acute lymphoblastic leukemia (ALL) is the most common
malignancy of childhood with and estimated 2000 new cases in the
United States each year. With current therapy over half of these
children will be cured of their disease and will be at risk for the
late effects of their therapy. We propose a multi-faceted study
of Second Malignant Neoplasms (SMN's) occurring after childhood
ALL. The first phase of the study will identify all cases of SMN's
occurring in children with ALL registered with the Childrens
Cancer Study Group (CCSG) since 1972. The estimated risk of
developing a SMN following childhood ALL will be calculated and
patient characteristics of this group of patients described.
Cohort analysis will be performed in an effort to identify patient
characteristics present at the time of diagnosis of ALL that may
be predictive of increased risk for the occurrence of SMN's. In
the second phase of the study two case-control studies will be
conducted. The first of these case-control studies will examine
risk associated with patient characteristics at diagnosis and the
specific effects of chemotherapies and radiation therapy on the
occurrence of second malignant neoplasms. Information regarding
age, sex, WBC count, morphology, and immunologic characteristic
of the leukemic cells are maintained for all patients by the CCSG
and will be made available to this study for analysis. Therapy
records for cases and controls will be reviewed for analysis of the
effects of specific chemotherapeutic agents and radiation
therapy. The second case-control study will test the hypothesis
that a population at risk for the development of SMN's can be
described by the patients past medical history, family history, or
exposures. Telephone interviews will be conducted for cases and
controls and data obtained regarding multiple parameters
including family cancer history, other significant family disease
history, patental exposures and occupations, patients exposures,
pre-natal and peri-natal events, and pre-existing patient illnesses.
These data will then be analyzed in an effort to identify any
parameters that may define an at risk population. The
information gained from this study will contribute important
information as modification are made to decrease the toxicity
while preserving the efficacy of existing treatment protocols for
childhood ALL.
A case-controls study will also be undertaken in an effort to
identify pre-natal and peri-natal risk factors for neuroblastoma,
the most common malignancy in the first year of life. This study
will utilize information coded on birth certificates and
supplemental information forms for cases of neuroblastoma
identified and born in Minnesota and matched controls. The
results of this study can provide valuable insight into pre-natal
and peri-natal influences of several pediatric neoplasms.
期刊论文(10)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
A reply to M. F. Greaves: toward a testable etiology of childhood acute lymphoblastic leukemia.
对 M. F. Greaves 的回复:针对儿童急性淋巴细胞白血病的可测试病因学。
DOI:
--
发表时间:
1990
期刊:
Leukemia
影响因子:
11.4
作者:
[Neglia,JP, Severson,RK, Linet,MS]
通讯作者:
Linet,MS
Epidemiology of the childhood acute leukemias.
儿童急性白血病的流行病学。
DOI:
10.1016/s0031-3955(16)36505-1
发表时间:
1988
期刊:
Pediatric clinics of North America
影响因子:
2.6
作者:
[Neglia,JP, Robison,LL]
通讯作者:
Robison,LL
DOI:
10.1136/jmg.27.2.130
发表时间:
1990-02
期刊:
Journal of Medical Genetics
影响因子:
4
作者:
[M. Nance;J. Neglia;Dinesh Talwar;S. Berry;Dillon M. Nance]
通讯作者:
M. Nance;J. Neglia;Dinesh Talwar;S. Berry;Dillon M. Nance
Detection of metastatic neuroblastoma in bone marrow biopsy specimens with an antibody to neuron-specific enolase.
使用神经元特异性烯醇化酶抗体检测骨髓活检标本中的转移性神经母细胞瘤。
DOI:
--
发表时间:
1992
期刊:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子:
--
作者:
[Crary,GS, Singleton,TP, Neglia,JP, Swanson,PE, Strickler,JG]
通讯作者:
Strickler,JG
Kidney size at diagnosis of childhood acute lymphocytic leukemia: lack of prognostic significance for outcome.
儿童急性淋巴细胞白血病诊断时的肾脏大小:对结果缺乏预后意义。
DOI:
10.1097/00043426-198824000-00005
发表时间:
1988
期刊:
The American journal of pediatric hematology/oncology
影响因子:
--
作者:
[Neglia,JP, Day,DL, Swanson,TV, Ramsay,NK, Robison,LL, NesbitJr,ME]
通讯作者:
NesbitJr,ME
Bedside to Bench and Back Again: Training Pediatricians in Translational Research
-
批准号:8083376
-
项目类别:
-
资助金额:$43.08万
-
财政年份:2010
-
负责人:Joseph P Neglia
-
依托单位:
Bedside to Bench and Back Again: Training Pediatricians in Translational Research
-
批准号:8402155
-
项目类别:
-
资助金额:$26.51万
-
财政年份:2010
-
负责人:Joseph P Neglia
-
依托单位:
Bedside to Bench and Back Again: Training Pediatricians in Translational Research
-
批准号:8604167
-
项目类别:
-
资助金额:$42.19万
-
财政年份:2010
-
负责人:Joseph P Neglia
-
依托单位:
Bedside to Bench and Back Again: Training Pediatricians in Translational Research
-
批准号:8209130
-
项目类别:
-
资助金额:$42.9万
-
财政年份:2010
-
负责人:Joseph P Neglia
-
依托单位:
SECOND MALIGNANT NEOPLASMS FOLLOWING CHILDHOOD LEUKEMIA
-
批准号:3079744
-
项目类别:
-
资助金额:$7.51万
-
财政年份:1987
-
负责人:Joseph P Neglia
-
依托单位:
SECOND MALIGNANT NEOPLASMS FOLLOWING CHILDHOOD LEUKEMIA
-
批准号:3079743
-
项目类别:
-
资助金额:$7.01万
-
财政年份:1987
-
负责人:Joseph P Neglia
-
依托单位:
SECOND MALIGNANT NEOPLASMS FOLLOWING CHILDHOOD LEUKEMIA
-
批准号:3079742
-
项目类别:
-
资助金额:$5.67万
-
财政年份:1987
-
负责人:Joseph P Neglia
-
依托单位:
SECOND MALIGNANT NEOPLASMS FOLLOWING CHILDHOOD LEUKEMIA
-
批准号:3079741
-
项目类别:
-
资助金额:$4.86万
-
财政年份:1987
-
负责人:Joseph P Neglia
-
依托单位:
CHILDRENS CANCER GROUP
-
批准号:6124403
-
项目类别:
-
资助金额:$29.62万
-
财政年份:1976
-
负责人:Joseph P Neglia
-
依托单位:
CHILDREN'S CANCER GROUP
-
批准号:2607960
-
项目类别:
-
资助金额:$39.1万
-
财政年份:1976
-
负责人:Joseph P Neglia
-
依托单位:
CHILDRENS CANCER GROUP
-
批准号:6328853
-
项目类别:
-
资助金额:$31.05万
-
财政年份:1976
-
负责人:Joseph P Neglia
-
依托单位:
CHILDREN'S CANCER GROUP
-
批准号:2007065
-
项目类别:
-
资助金额:$37.85万
-
财政年份:1976
-
负责人:Joseph P Neglia
-
依托单位:
CHILDRENS CANCER GROUP
-
批准号:6475715
-
项目类别:
-
资助金额:$31.98万
-
财政年份:1976
-
负责人:Joseph P Neglia
-
依托单位:
CHILDRENS CANCER GROUP
-
批准号:2742535
-
项目类别:
-
资助金额:$31.15万
-
财政年份:1976
-
负责人:Joseph P Neglia
-
依托单位:
海外基金