Development of human tissue processing facilities to support research into composite biomarkers for disease detection

开发人体组织加工设施以支持疾病检测复合生物标志物的研究

• 批准号: 75955
• 金额: $ 8.6万
• 依托单位: UNIVERSITY OF OXFORD
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=75955
• 关键词: Development; human; tissue; processing; facilities

Collaboration between the academic and commercial sectors will be vital for the future of healthcare. Increasingly we are moving towards using software tools that combine the results of many different measurements and tests. This creates a comprehensive, overall picture of disease in an individual patient. These sophisticated tools provide valuable support and information for healthcare professionals to make clinical and treatment decisions. Collaboration between the academic and commercial sectors is necessary to develop these tools as they rely on both cutting-edge academic research in the understanding of disease, and their translation to the clinic as regulated products.We will second the manager of the Live Tissue Facility (LTF) in the Department of Oncology, University of Oxford to Perspectum Ltd. The LTF is a dedicated laboratory facility for processing and analysing human tissue samples (e.g. blood samples, tumour biopsy specimens) to support research. Perspectum are world leaders in using sophisticated magnetic resonance imaging (MRI) techniques to detect markers of disease.The work that we do will develop and adapt the LTF to make it accessible to Perspectum and suitable for their research needs. This will mostly involve changes in procedures and processes and so we will be able to use existing LTF funds to achieve this. The result will be a facility that is suitable and accessible for both institutions. Using this facility Perspectum will work towards combining human tissue data with their cutting-edge imaging technology, genetic information and pathology data to create sophisticated and innovative new software tools.The secondee will bring knowledge to Perspectum of how to process and analyse human tissue and how to equip a laboratory so that it is suitable for this work. They will also gain valuable experience of doing research in the commercial sector and take this knowledge back to the University. Here, they will use the knowledge to improve the LTF so that it is more attractive to other companies that may want to use it. The secondee will also learn to identify opportunities to commercialise the services provided by the LTF. This will generate income for the LTF and allow it to grow and expand into bigger and more impactful research projects. This will help generate more collaborations between the academic and commercial sectors and lead to faster advances in health care research.

学术和商业部门之间的合作对医疗保健的未来至关重要。我们越来越多地使用软件工具，将许多不同测量和测试的结果联合收割机结合起来。这创造了一个全面的，整体的疾病在个别病人的图片。这些复杂的工具为医疗保健专业人员提供了宝贵的支持和信息，以做出临床和治疗决策。为了开发这些工具，学术界和商业界之间的合作是必要的，因为它们依赖于对疾病的理解的尖端学术研究，以及将其作为受监管产品转化为临床。我们将借调肿瘤学系活组织设施（LTF）的经理，Perspectum LTF是一个专门用于处理和分析人体组织样本的实验室设施（例如血液样本、肿瘤活检标本）以支持研究。Perspectum是使用先进的磁共振成像（MRI）技术来检测疾病标志物的世界领导者。我们所做的工作将开发和调整LTF，使其可用于Perspectum并适合他们的研究需求。这将主要涉及程序和流程的变化，因此我们将能够使用现有的长期信托基金来实现这一目标。其结果将是一个适合两个机构的设施。Perspectum将利用该设施将人体组织数据与其尖端的成像技术、遗传信息和病理学数据相结合，以创建复杂和创新的新软件工具。借调人员将为Perspectum带来如何处理和分析人体组织的知识，以及如何配备适合这项工作的实验室。他们还将获得在商业领域进行研究的宝贵经验，并将这些知识带回大学。在这里，他们将利用这些知识来改进LTF，使其对其他可能希望使用它的公司更具吸引力。借调人员还将学习如何识别LTF提供的服务商业化的机会。这将为LTF带来收入，并使其能够发展和扩展到更大，更有影响力的研究项目。这将有助于学术和商业部门之间产生更多的合作，并导致医疗保健研究的更快发展。