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RELATION OF BLOOD PRESSURE AND RENAL HEMODYNAMIC RESPONSES TO LOSARTAN

RELATION OF BLOOD PRESSURE AND RENAL HEMODYNAMIC RESPONSES TO LOSARTAN
血压与氯沙坦肾血流动力学反应的关系
批准号：
6279002
负责人：
HOWARD PRATT
金额：
$1.68万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6279002
关键词：
African American angiotensinogen antihypertensive agents blood pressure cardiovascular disorder chemotherapy clinical research drug screening /evaluation hemodynamics human subject human therapy evaluation hypertension salt intake

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英文摘要
The current proposal is directed at an understanding of the genetic causes of hypertension in blacks. There is evidence that blacks in comparison to whites have an increased sodium reabsorption that underlies an increased susceptibility to hypertension. We will study whether an increase in angiotension II acitvity within the kidney and/or an increase in reabsorption of sodium through the amiloride-sensitive epithelial sodium channel is associated with specific variants for the angiotensiogen and aniotension I AT1 receptor gene sand the genes for ENaC.
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ASCERTAINMENT OF HYPERTENSIVE PATIENTS FOR GENETIC STUDIES
RELATION OF BLOOD PRESSURE AND RENAL HEMODYNAMIC RESPONSES TO LOSARTAN
RELATION OF BLOOD PRESSURE AND RENAL HEMODYNAMIC RESPONSES TO LOSARTAN
RELATIONSHIP OF RACE TO RENAL HEMODYNAMICS
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