RELATION OF BLOOD PRESSURE AND RENAL HEMODYNAMIC RESPONSES TO LOSARTAN

目前的建议是针对遗传原因的理解 黑人患高血压的风险。有证据表明，与黑人相比， 白人的钠重吸收增加，这是增加的基础 易患高血压。我们会研究是否会增加 血管紧张素II在肾脏内的活性和/或增加 阿米洛利敏感上皮钠对钠的重吸收 通道与血管紧张素原和 血管紧张素-1受体基因和ENaC基因。

The current proposal is directed at an understanding of the genetic causes of hypertension in blacks. There is evidence that blacks in comparison to whites have an increased sodium reabsorption that underlies an increased susceptibility to hypertension. We will study whether an increase in angiotension II acitvity within the kidney and/or an increase in reabsorption of sodium through the amiloride-sensitive epithelial sodium channel is associated with specific variants for the angiotensiogen and aniotension I AT1 receptor gene sand the genes for ENaC.