RELATION OF BLOOD PRESSURE AND RENAL HEMODYNAMIC RESPONSES TO LOSARTAN

目前的建议是针对遗传原因的理解 黑人的高血压。 有证据表明，与黑人相比， 白人的钠重吸收增加， 易患高血压。 我们将研究是否增加 肾内血管紧张素II活性和/或 钠通过阿米洛利敏感的上皮钠重吸收 通道与血管紧张素原的特定变体相关， 血管紧张素Ⅱ AT1受体基因和ENaC基因。

The current proposal is directed at an understanding of the genetic causes of hypertension in blacks. There is evidence that blacks in comparison to whites have an increased sodium reabsorption that underlies an increased susceptibility to hypertension. We will study whether an increase in angiotension II acitvity within the kidney and/or an increase in reabsorption of sodium through the amiloride-sensitive epithelial sodium channel is associated with specific variants for the angiotensiogen and aniotension I AT1 receptor gene sand the genes for ENaC.