RELATION OF BLOOD PRESSURE AND RENAL HEMODYNAMIC RESPONSES TO LOSARTAN

血压与氯沙坦肾血流动力学反应的关系

• 批准号: 6117807
• 负责人: HOWARD PRATT
• 金额: $ 1.7万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117807
• 关键词: African American; angiotensinogen; antihypertensive agents; blood pressure; cardiovascular disorder chemotherapy; clinical research; drug screening /evaluation; hemodynamics; human subject; human therapy evaluation; hypertension; salt intake

The current proposal is directed at an understanding of the genetic causes of hypertension in blacks. There is evidence that blacks in comparison to whites have an increased sodium reabsorption that underlies an increased susceptibility to hypertension. We will study whether an increase in angiotension II acitvity within the kidney and/or an increase in reabsorption of sodium through the amiloride-sensitive epithelial sodium channel is associated with specific variants for the angiotensiogen and aniotension I AT1 receptor gene sand the genes for ENaC.

目前的提议旨在了解遗传原因 黑人高血压。 有证据表明黑人相比 白人的钠重吸收增加，这是增加 易患高血压。 我们将研究是否增加 肾脏内血管紧张素 II 活性和/或 通过阿米洛利敏感的上皮钠重吸收钠 通道与血管紧张素的特定变体相关， 抗血压 I AT1 受体基因和 ENaC 基因。