BONE LEAD STORES AND PREGNANCY INDUCED HYPERTENSION

骨铅储存和妊娠引起的高血压

• 批准号: 2750562
• 负责人: JOHN D BOGDEN
• 金额: $ 27.14万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2750562
• 关键词: blood pressure; bone metabolism; calcium metabolism; dietary calcium; dietary mineral; gastrointestinal absorption /transport; laboratory rat; lead poisoning; nutrition related tag; osteocalcin; parathyroid hormones; pregnancy toxemia /hypertension; vitamin D

DESCRIPTION (Adapted from the Investigator's Abstract): Pregnancy-induced hypertension and preeclampsia remain leading causes of fetal and maternal morbidity and mortality, occurring in as many as 10% of pregnancies in the United States. They are a particular problem in first and adolescent pregnancies. The proposed study will investigate relationships during pregnancy among five factors: blood pressure, temporal changes in blood lead, dietary calcium intake, current lead ingestion, and bone lead mobilization. Rats will be exposed to lead prior to pregnancy, during pregnancy, or at both times, and will be fed a diet containing a low or normal concentration of calcium during pregnancy. Control groups of pregnant rats will not be exposed to lead and non-pregnant animals will also be studied. Variables to be measured include systolic blood pressure, blood and bone lead concentrations, and serum concentrations of parathormone, osteocalcin, and 25 and 1,25 dihydroxyvitamin D. The study will allow determination of whether the natural rise in blood lead late in pregnancy contributes to pregnancy-induced hypertension. It will also permit assessment of the relative effects of current lead exposure versus bone lead mobilization on blood lead and blood pressure during pregnancy. These studies will focus on quantifying blood lead/blood pressure relationships in the rat and investigation of factors that may influence this relationship during pregnancy. The concept that calcium supplementation is beneficial during pregnancy is not new. However, the proposed studies utilize lead exposure as a way to study if the mechanism of prevention of increases in blood pressure by dietary calcium during pregnancy is by suppression of lead absorption from the diet and/or suppression of bone lead mobilization. Thus, these studies may explain the variability of the results of other investigations that have assessed the independent effects of calcium and lead on blood pressure during pregnancy.

描述（改编自研究者摘要）：妊娠诱导 高血压和先兆子痫仍然是胎儿和母亲 发病率和死亡率，发生在多达10%的怀孕， 美国的 他们是一个特殊的问题，在第一和青少年 怀孕。 这项拟议的研究将调查 怀孕五个因素：血压，血液的时间变化 铅、膳食钙摄入量、当前铅摄入量和骨铅 动员。 大鼠将在怀孕前、怀孕期间和怀孕后暴露于铅。 怀孕，或在这两个时间，并将喂养饮食含有低或 怀孕期间钙的正常浓度。 的对照组 怀孕的老鼠不会接触到铅，而非怀孕的动物也会接触到铅。 被研究。 待测量的变量包括收缩压、血 和骨铅浓度，以及甲状旁腺激素的血清浓度， 骨钙素和25和1，25二羟维生素D。这项研究将使 测定血铅是否在妊娠后期自然上升 会导致妊娠高血压 它还将允许 评估当前铅暴露与骨铅暴露的相对影响 妊娠期血铅和血压的动员。 这些 研究将侧重于量化血铅/血压的关系， 对可能影响这种关系因素的评估和调查 孕期 补钙有益的概念 怀孕并不新鲜。 然而，拟议的研究使用铅 暴露作为一种方式来研究，如果机制的预防增加， 怀孕期间通过膳食钙来控制血压是通过抑制铅来实现的 从饮食中吸收和/或抑制骨铅动员。 因此，这些研究可以解释其他研究结果的变异性。 评估钙的独立影响的研究， 铅对怀孕期间血压的影响