BONE LEAD STORES AND PREGNANCY INDUCED HYPERTENSION

骨铅储存和妊娠引起的高血压

• 批准号: 6043910
• 负责人: JOHN D BOGDEN
• 金额: $ 27.95万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6043910
• 关键词: blood pressure; bone metabolism; calcium metabolism; dietary calcium; dietary mineral; gastrointestinal absorption /transport; laboratory rat; lead poisoning; nutrition related tag; osteocalcin; parathyroid hormones; pregnancy toxemia /hypertension; vitamin D

DESCRIPTION (Adapted from the Investigator's Abstract): Pregnancy-induced hypertension and preeclampsia remain leading causes of fetal and maternal morbidity and mortality, occurring in as many as 10% of pregnancies in the United States. They are a particular problem in first and adolescent pregnancies. The proposed study will investigate relationships during pregnancy among five factors: blood pressure, temporal changes in blood lead, dietary calcium intake, current lead ingestion, and bone lead mobilization. Rats will be exposed to lead prior to pregnancy, during pregnancy, or at both times, and will be fed a diet containing a low or normal concentration of calcium during pregnancy. Control groups of pregnant rats will not be exposed to lead and non-pregnant animals will also be studied. Variables to be measured include systolic blood pressure, blood and bone lead concentrations, and serum concentrations of parathormone, osteocalcin, and 25 and 1,25 dihydroxyvitamin D. The study will allow determination of whether the natural rise in blood lead late in pregnancy contributes to pregnancy-induced hypertension. It will also permit assessment of the relative effects of current lead exposure versus bone lead mobilization on blood lead and blood pressure during pregnancy. These studies will focus on quantifying blood lead/blood pressure relationships in the rat and investigation of factors that may influence this relationship during pregnancy. The concept that calcium supplementation is beneficial during pregnancy is not new. However, the proposed studies utilize lead exposure as a way to study if the mechanism of prevention of increases in blood pressure by dietary calcium during pregnancy is by suppression of lead absorption from the diet and/or suppression of bone lead mobilization. Thus, these studies may explain the variability of the results of other investigations that have assessed the independent effects of calcium and lead on blood pressure during pregnancy.

描述（改编自研究者摘要）：妊娠诱导

项目成果

Lead in breast milk and maternal bone turnover.

母乳和母亲骨转换中的铅。

• DOI: 10.1067/mob.[phone]
• 发表时间: 2002
• 期刊: American journal of obstetrics and gynecology
• 影响因子: 9.8
• 作者: Sowers,MaryFranR;Scholl,TheresaO;Hall,Gene;Jannausch,MaryL;Kemp,FrancisW;Li,Xinhua;Bogden,JohnD
• 通讯作者: Bogden,JohnD

Effects of weight loss and exercise on the distribution of lead and essential trace elements in rats with prior lead exposure.

减肥和运动对先前接触铅的大鼠中铅和必需微量元素分布的影响。

• DOI: 10.1289/ehp.99107657
• 发表时间: 1999
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Han,S;Li,W;Jamil,U;Dargan,K;Orefice,M;Kemp,FW;Bogden,JD
• 通讯作者: Bogden,JD

Effects of lead exposure before pregnancy and dietary calcium during pregnancy on fetal development and lead accumulation.

• DOI: 10.1289/ehp.00108527
• 发表时间: 2000-06
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Han S;Pfizenmaier DH;Garcia E;Eguez ML;Ling M;Kemp FW;Bogden JD
• 通讯作者: Bogden JD

Lead poisoning--one approach to a problem that won't go away.

铅中毒——解决这个无法消失的问题的一种方法。

• DOI: 10.1289/ehp.105-1470406
• 发表时间: 1997
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Bogden,JD;Oleske,JM;Louria,DB
• 通讯作者: Louria,DB