Fundamental roles of aquaporin-1 channels in cell migration and morphology

aquaporin-1 通道在细胞迁移和形态学中的基本作用

• 批准号: DP190101745
• 负责人: Prof Andrea Yool
• 金额: $ 29.72万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101745
• 关键词: Fundamental; roles; aquaporin; channels; cell

This project aims to investigate cell migration mechanisms and the roles of aquaporin channels in controlling cell motility and morphology. The ability of cells to move and maintain proper shape is important for development, repair and survival in multicellular organisms. This project will test the role of mammalian aquaporin-1 channels in enabling rapid migration in normal and cancer cells, in repairing barrier layers in kidney and brain, and in allowing red blood cells to maintain the classic disk-shape needed for optimal transport. Outcomes will define features of aquaporin-1 that provide these functions, using molecular, optical and pharmacological tools. Results will define aquaporin channel properties that enable optimal cellular function.

该项目旨在研究细胞迁移机制和水通道在控制细胞运动和形态中的作用。细胞移动和保持适当形状的能力对多细胞生物体的发育、修复和生存至关重要。该项目将测试哺乳动物水通道-1通道在实现正常细胞和癌细胞的快速迁移、修复肾脏和大脑中的屏障层以及使红细胞保持最佳运输所需的经典盘状方面的作用。结果将利用分子、光学和药理学工具确定提供这些功能的水通道蛋白-1的特征。结果将定义使细胞功能最佳的水通道特性。