IMPLICATIONS OF HLA POLYMORPHISM FOR DONOR RECRUITMENT

HLA 多态性对捐赠者招募的影响

• 批准号: 2685483
• 负责人: MOTOMI MORI
• 金额: $ 21.89万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2685483
• 关键词: alleles; bone marrow transplantation; clinical research; electron microscopy; genetic polymorphism; geographic site; histocompatibility antigens; histocompatibility typing; homologous transplantation; human subject; phenotype; racial /ethnic difference; statistics /biometry; tissue donors; tissue resource /registry

DESCRIPTION: (Adapted from Investigator's Abstract) During the last three decades, bone marrow transplantation (BMT) has become the standard care for the treatment of many hematological malignancies. The idea donor, one who possesses the same HLA-A, B, DR phenotype as that of the patient, is found less than 35% of the time among family members and less than 50% of the time among unrelated donors. Furthermore, minority patients have even lower probability of finding an HLA matched donor. The overall goals of this project are to evaluate the feasibility of finding unrelated matched donors for bone marrow transplant (BMT) patients as a function of HLA-A, B, DR phenotype, race and geographical location of recipient and donor, to develop projections which will facilitate management strategies for recruiting marrow donors on the basis of race and geographical location, and to develop tools which will permit analysis of clinical outcomes on the basis of the probability of haplotype match rather than phenotype match among unrelated BMT patients. Specific aims of the project are to: (1) compare HLA polymorphism among various racial groups and in different geographical regions of the United States; (2) estimate the probability of finding a 6/6 HLA-A, B, DR match and 6/6 or 5/6 match various racial groups as well as for geographically defined groups; (3) estimate the number of donors required from each racial group and geographical region in order to achieve equal access among various racial groups: (4) assess the extent to which European and other foreign marrow donor registries can assist U.S. patients in finding a matched donor by contributing to the diversity of phenotypes represented in the registry: (5) evaluate HLA polymorphism using DNA typing data and to estimate the probability of finding an HLA match at the level of allele rather than antigen for each racial group; (6) evaluate the impact of changes in matching criteria based on molecular determinations of phenotype upon the probability of finding a matched donor for each racial group; (7) develop tools which permit evaluation of impact of genotype match on clinical outcomes among unrelated BMT patients.

描述：（改编自研究者摘要） 三十年来，骨髓移植（BMT）已成为标准 护理治疗许多血液恶性肿瘤。 这个想法 捐献者，具有与捐献者相同的HLA-A、B、DR表型 患者中，不到 35% 的时间是在家庭成员中发现的，并且 在不相关的捐赠者中，这种情况的发生率低于 50%。 此外，少数 患者找到 HLA 匹配捐献者的可能性甚至更低。 该项目的总体目标是评估 寻找不相关的匹配捐献者进行骨髓移植 (BMT) 患者作为 HLA-A、B、DR 表型、种族和地理的函数 接受者和捐助者的位置，以制定预测 促进招募骨髓捐赠者的管理策略 种族和地理位置的基础，并开发工具 允许根据以下概率分析临床结果 不相关的 BMT 之间的单倍型匹配而不是表型匹配 患者。 该项目的具体目标是： (1) 比较 HLA 不同种族群体和不同地理区域之间的多态性 美国的地区； (2)估计发现的概率 6/6 HLA-A、B、DR 匹配以及 6/6 或 5/6 与不同种族群体匹配 以及地理上界定的群体； (3) 估计数量 需要每个种族群体和地理区域的捐助者按顺序 实现不同种族群体之间的平等机会：(4) 评估 欧洲和其他外国骨髓捐赠登记处可以在多大程度上 帮助美国患者找到匹配的捐赠者 注册表中表现型的多样性：(5) 评估 HLA 使用 DNA 分型数据进行多态性分析并估计概率 在等位基因水平而非抗原水平找到每个 HLA 匹配 种族群体； (6)评估匹配标准变化的影响 基于表型概率的分子测定 为每个种族群体寻找匹配的捐赠者； (7) 开发工具 允许评估基因型匹配对临床结果的影响 不相关的 BMT 患者。