IMPLICATIONS OF HLA POLYMORPHISM FOR DONOR RECRUITMENT

HLA 多态性对捐赠者招募的影响

• 批准号: 2685483
• 负责人: MOTOMI MORI
• 金额: $ 21.89万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2685483
• 关键词: alleles; bone marrow transplantation; clinical research; electron microscopy; genetic polymorphism; geographic site; histocompatibility antigens; histocompatibility typing; homologous transplantation; human subject; phenotype; racial /ethnic difference; statistics /biometry; tissue donors; tissue resource /registry

DESCRIPTION: (Adapted from Investigator's Abstract) During the last three decades, bone marrow transplantation (BMT) has become the standard care for the treatment of many hematological malignancies. The idea donor, one who possesses the same HLA-A, B, DR phenotype as that of the patient, is found less than 35% of the time among family members and less than 50% of the time among unrelated donors. Furthermore, minority patients have even lower probability of finding an HLA matched donor. The overall goals of this project are to evaluate the feasibility of finding unrelated matched donors for bone marrow transplant (BMT) patients as a function of HLA-A, B, DR phenotype, race and geographical location of recipient and donor, to develop projections which will facilitate management strategies for recruiting marrow donors on the basis of race and geographical location, and to develop tools which will permit analysis of clinical outcomes on the basis of the probability of haplotype match rather than phenotype match among unrelated BMT patients. Specific aims of the project are to: (1) compare HLA polymorphism among various racial groups and in different geographical regions of the United States; (2) estimate the probability of finding a 6/6 HLA-A, B, DR match and 6/6 or 5/6 match various racial groups as well as for geographically defined groups; (3) estimate the number of donors required from each racial group and geographical region in order to achieve equal access among various racial groups: (4) assess the extent to which European and other foreign marrow donor registries can assist U.S. patients in finding a matched donor by contributing to the diversity of phenotypes represented in the registry: (5) evaluate HLA polymorphism using DNA typing data and to estimate the probability of finding an HLA match at the level of allele rather than antigen for each racial group; (6) evaluate the impact of changes in matching criteria based on molecular determinations of phenotype upon the probability of finding a matched donor for each racial group; (7) develop tools which permit evaluation of impact of genotype match on clinical outcomes among unrelated BMT patients.

描述：(改编自《调查者摘要》) 三十年来，骨髓移植(BMT)已经成为标准 治疗多种恶性血液病。这个想法 供者，具有与患者相同的人类白细胞抗原A、B、DR表型的人 患者，在家庭成员中被发现的几率不到35%， 在无血缘关系的捐赠者中，不到50%的时间。此外，少数族裔 患者找到匹配的捐献者的可能性甚至更低。 该项目的总体目标是评估以下项目的可行性 寻找无血缘关系的匹配供者进行骨髓移植 患者受人类白细胞抗原-A、B、DR表型、种族和地域的影响 接受者和捐赠者的位置，以制定预测，以 促进招募骨髓捐赠者的管理策略 基于种族和地理位置，并开发工具，以满足 允许根据以下概率对临床结果进行分析 无关骨髓移植患者的单倍型匹配而不是表型匹配 病人。本项目的具体目标是：(1)比较人类白细胞抗原 不同种族、不同地域人群的多态性 美国各地区；(2)估计发现的概率 A 6/6与人类白细胞抗原A、B、DR匹配，6/6或5/6与不同种族匹配 以及地理上定义的群体；(3)估计 需要来自每个种族群体和地理区域的捐赠者 实现不同种族群体之间的平等机会：(4)评估 欧洲和其他外国骨髓捐赠者登记可以达到的程度 帮助美国患者找到匹配的捐赠者 注册表型的多样性：(5)评估人类白细胞抗原 利用DNA分型数据进行多态分析，并估计 在等位基因而不是抗原水平上为每个人找到匹配的人类白细胞抗原 种族群体；(6)评估匹配标准变化的影响 基于表型的分子决定的可能性 为每个种族找到匹配的捐赠者；(7)开发工具，以 允许评估基因匹配对临床结果的影响 无血缘关系的骨髓移植患者。