Biostatistics Shared Resources Core

生物统计学共享资源核心

• 批准号: 10116300
• 负责人: MOTOMI MORI
• 金额: $ 83.52万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10116300
• 关键词: Acute Lymphocytic Leukemia; Adherence; Affect; Anus; Basic Science; Big Data; Biological; Biometry; Biostatistics Shared Resource; Blood; Bone Density; Bone Mineral Contents; Cancer Center Support Grant; Cancer Control; Child; Childhood Acute Lymphocytic Leukemia; Clinical Investigator; Clinical Oncology; Clinical Research; Clinical Trials; Clinical assessments; Collaborations; Complex; Computer Systems; Computer software; Consult; Consultations; Data; Data Analyses; Department chair; Development; Diagnosis; Disease Marker; Dose; Drug Kinetics; Educational Status; Educational workshop; Enrollment; Ensure; Faculty; Follow-Up Studies; Frequencies; Funding; Genes; Genetic; Genetic Markers; Genomics; Goals; Growth; Immunotherapy; Information Services; Infrastructure; Journals; Laboratories; Late Effects; Life Cycle Stages; Malignant Childhood Neoplasm; Malignant Neoplasms; Measures; Methodology; Methods; Mission; Molecular; Motivation; Mutation; Nature; Neuropathy; Newly Diagnosed; Oncology; Outcome; Paper; Patients; Physical Function; Physical activity; Physical therapy; Population; Process; Publications; Quality of life; Radiation exposure; Radiology Specialty; Randomized; Remission Induction; Research; Research Design; Research Personnel; Research Project Grants; Residual Neoplasm; Resource Sharing; Risk; Saint Jude Children' s Research Hospital; Scientific Advances and Accomplishments; Severities; Survivors; System; Therapeutic; Therapeutic Intervention; Time; Translating; United States; Update; Vincristine; Work; anticancer research; base; cancer clinical trial; cohort; design; disorder subtype; electronic data capture system; exercise intensity; experience; improved; indexing; lectures; leukemia treatment; medulloblastoma; member; multi-site trial; neurotoxicity; personalized medicine; precision medicine; programs; recruit; relapse risk; sound; survivorship; translational scientist; treatment as usual

PROJECT SUMMARY/ABSTRACT— Biostatistics Shared Resource The Biostatistics Shared Resource (BSR) is a SJCCC managed shared resource with the overarching mission of impacting pediatric cancer through biostatistics collaboration and consulting, and through comprehensive, effective, and timely biostatistical support to Center members. BSR has a highly experienced and interactive team of biostatisticians who work collaboratively with researchers who are conducting leading edge basic science, clinical research, and population and survivorship research from the 5 SJCCC Programs. This is evidenced by the high level of collaborative publications and key scientific contributions in high-impact journals such as Journal of Clinical Oncology (n=31), Cancer (n=31), Nature Genetics (n=9), and Lancet Oncology (n=4). In addition, BSR biostatisticians are well integrated into the clinical trial teams providing statistical support throughout the life cycle of the research project from concept development through publication. During the last funding period, 85% of all SJCCC publications used the BSR and 77% (n=358/468) of all collaborative publications with a biostatistician as a co-author were associated with SJCCC programs. These included papers from all 5 of the programs: CCSP (n = 103), CBP (n = 1), DBSTP (n = 66), NBTP (n = 83), and HMP (n = 105). A total of 125 St. Jude investigators and their staff used the BSR during the index year (FY2017). Of those, 71 (57%) were SJCCC members. The BSR faculty also offer workshops, office consultations, lectures, seminars, Grand Rounds, and courses on study design, analysis methods, and software implementation to fellows, research staff, and faculty. The BSR is led by Dr. Deo Kumar Srivastava who has more than 23 years' experience in the statistical design and analysis of cancer research and cancer clinical trials. He is supported by 9 faculty biostatisticians and 13 master's-level trained staff, ensuring that BSR support is available to investigators throughout all 5 programs. During our most recent funding period, BSR has witnessed growth driven by the strengthening of the scientific programs, research in genomic characterization of pediatric cancers, and focus on complex precision medicine SJCCC investigator-initiated multisite trials. Goals for the next funding period include continuing to provide state-of-the-art statistical support to all SJCCC investigators including new investigators, and targeted recruitment of biostatisticians to strengthen expertise in personalized medicine, immunotherapy, and in expansion of high-throughput big data. Lastly, BSR will closely partner with the Information Services department in the implementation of the new software provided by the Clinical Trials Management System.

项目摘要/摘要 — 生物统计学共享资源 生物统计共享资源 (BSR) 是 SJCCC 管理的共享资源，其首要任务是 通过生物统计学合作和咨询，以及通过全面、 为中心成员提供有效、及时的生物统计支持。 BSR 拥有经验丰富、互动性强的团队 生物统计学家团队与正在进行前沿基础研究的研究人员合作 5 个 SJCCC 项目的科学、临床研究以及人口和生存研究。这是 高影响力期刊上的高水平合作出版物和关键科学贡献证明了这一点 例如《临床肿瘤学杂志》(n=31)、《癌症》(n=31)、《自然遗传学》(n=9) 和《柳叶刀肿瘤学》(n=4)。 此外，BSR生物统计学家很好地融入了临床试验团队，提供统计支持 贯穿研究项目从概念开发到出版的整个生命周期。最后期间 资助期内，85% 的 SJCCC 出版物使用了 BSR，77% (n=358/468) 的所有协作出版物使用了 BSR 由生物统计学家作为合著者的出版物与 SJCCC 项目相关。这些包括论文 来自所有 5 个计划：CCSP (n = 103)、CBP (n = 1)、DBSTP (n = 66)、NBTP (n = 83) 和 HMP (n = 105)。 在索引年（2017 财年），共有 125 名 St. Jude 调查员及其工作人员使用了 BSR。其中，71 (57%) 是 SJCCC 会员。 BSR 教师还提供讲习班、办公室咨询、讲座、研讨会、 大查房，以及为研究员提供的研究设计、分析方法和软件实施课程， 研究人员和教师。 BSR 由 Deo Kumar Srivastava 博士领导，他拥有超过 23 年的丰富经验 在癌症研究和癌症临床试验的统计设计和分析方面拥有丰富的经验。他的支持者是 9 名生物统计学家和 13 名经过硕士培训的工作人员，确保 BSR 支持 所有 5 个项目的调查员。在我们最近的融资期间，BSR 见证了增长 在加强科学计划、儿科癌症基因组特征研究的推动下， 并专注于复杂的精准医学 SJCCC 研究者发起的多中心试验。下一次融资的目标 期间包括继续向所有 SJCCC 调查员提供最先进的统计支持，包括新的调查员 研究人员，并有针对性地招募生物统计学家以加强个性化医疗的专业知识， 免疫疗法，以及高通量大数据的扩展。最后，BSR 将与 信息服务部门实施临床试验提供的新软件 管理系统。