BIOSTATISTICS SHARED RESOURCE

骑士癌症研究所（Knight）的生物统计学共享资源（BSR）是一个癌症中心， 共享资源，并为在OHSU和合作机构进行癌症研究的基础，临床和人口科学研究人员提供生物统计学支持（例如，波特兰VA医学中心，Kaiser Permanente健康研究中心）。除了为个人研究人员提供支持外，BSR还帮助其他Knight共享资源解决他们的生物统计需求。BSR致力于 通过在癌症研究的各个层次和阶段提供量身定制的专业咨询，提高癌症研究的科学质量和统计复杂性。通过利用CCSG的支持，骑士机构的承诺，和其他癌症特定的赠款支持，BSR提供了广泛的生物统计学专业知识，并以具有成本效益的方式支持癌症研究人员。支持活动分为四大类：（1）授标前支持，（2）授标后支持，（3）基础设施支持，以及（4）教育和培训。奖前支持包括对研究和实验设计、样本量和功效分析的咨询，以及对制药商发起的临床方案和赠款提案的统计分析计划。奖后支持包括方案实施、数据管理、统计分析和手稿准备。基础设施支持是指与其他共享资源的合作项目，以加强整体研究基础设施，包括为高通量遗传学/基因组学研究制定和实施统计方案，通过参与方案审查和评估系统（即，临床研究审查委员会和数据与安全性监查委员会）。教育和培训活动包括参加各种 癌症杂志俱乐部，研究进展会议，短期生物统计研讨会，临床试验和统计遗传学的教学课程，以及BSR成员的专业发展活动。BSR被高度利用，并为骑士进行的癌症研究做出了重大贡献。2009年，BSR共协助了来自所有四个研究项目的55名研究人员的129个项目， 2 562个咨询小时，用于开展支助活动。2005年至2010年间，BSR协助了65份癌症相关出版物（65份已出版，9份正在出版、修订或提交）。BSR强调在最早阶段进行研究合作，因为大多数富有成效的研究都是在合作研究环境下进行的

The Biostatistics Shared Resource (BSR) of the Knight Cancer Institute (Knight) is a cancer-center managed shared resource and provides biostatistics support to basic, clinical and population science researchers who conduct cancer research at OHSU and partner institutions (e.g., Portland VA Medical Center, Kaiser Permanente Center for Health Research). In addition to providing support to individual researchers, the BSR also assists other Knight shared resources in addressing their biostatistics needs. The BSR strives to enhance the scientific quality and statistical sophistication of cancer research through tailored professional consultation at every level and stage of cancer research. By leveraging CCSG support, the Knight institutional commitment, and other cancer specific grant support, the BSR provides a wide range of biostatistics expertise and supports cancer researchers in a cost-effective manner. Support activities are divided into four major categories: (1) pre-award support, (2) post-award support, (3) infrastructure support, and (4) education and training. Pre-award support includes consultation on study and experimental designs, sample size and power analysis, and statistical analysis plan for investigator-initiated clinical protocols and grant proposals. Post-award support includes protocol implementation, data management, statistical analysis, and manuscript preparation. Infrastructure support refers to collaborative projects with other shared resources to enhance the overall research infrastructure, including development and implementation of statistical protocols for high-throughput genetics/genomics studies, clinical research support through participation in the Protocol Review and Monitorihg^System (i.e., Clinical Research Review Committee and Data and Safety Monitoring Committee). Education and training activities include participation in various cancer journal clubs, research-in-progress meetings, short-term biostatistics workshops, didactic courses in clinical trials and statistical genetics, and professional development activities for BSR members. The BSR is highly utilized and has contributed significantly to cancer research conducted at the Knight. In 2009 the BSR assisted a total of 129 projects from 55 investigators from all four research programs, provided a total of 2,562 consulting hours for investigator-support activities. Between 2005 and 2010, the BSR assisted 65 cancer relevant publications (65 published, 9 in press, revision or submitted). The BSR emphasizes research collaboration at the earliest stage possible as most productive research is conducted under a collaborative research environment