LONG TERM EFFECTS OF TEMPORAL LOBE EPILEPSY

颞叶癫痫的长期影响

• 批准号: 2704713
• 负责人: H REBECCA RAUSCH
• 金额: $ 20.46万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-02 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2704713
• 关键词: aging; behavior; behavioral /social science research tag; clinical research; cognition; emotions; functional ability; human subject; human therapy evaluation; longitudinal human study; neuropsychological tests; neurosurgery; partial seizure; postoperative complications; postoperative state; social adjustment

DESCRIPTION: The major goal of the proposed research is to provide much needed information as to the long-term behavior effects of temporal-lobe surgery. Temporal lobe surgery is the most frequently performed epilepsy surgery procedure. The clinical results of such surgery have been impressive. However, reports of the behavioral sequelae of surgery are limited, with most studies performed within the first year after surgery. While improvement in emotional and social domains have been reported in the short-term follow-up in the successfully-treated patients, the behavioral sequelae is not always positive. No long-term longitudinal studies of the behavioral effects of temporal lobe surgery are available. The proposed research meets the need for a systematic investigation of the long-term impact of temporal lobe surgery on medical, social and emotional functioning. Studies are based on the longitudinal follow-up of persons who had intractable epilepsy and who underwent a standardized clinical and psychological evaluation in a large university surgical diagnostic center. Three groups of patients are followed: Patients who underwent a standardized temporal lobe resection, patients who underwent an extra- temporal lobe resection and a comparison group of patients who underwent the same pre-surgical evaluation but did not qualify for/or refused surgery. The proposed studies will determine the extent to which the changes seen one year and 5 years after temporal lobe surgery are similar to those seen greater than 9 years post surgery. The interrelationship of emotional, cognitive, and social changes and selected clinical measures will be determined. Finally, as these patients approach ages when normal aging process begin, potential late changes in behavior will be identified. These changes will be related to the impact of seizures and other related treatment effects. These findings will be invaluable to clinicians and general health-care providers involved in clinical decisions on the surgical treatment of epilepsy. Such information will also be important for neurobehavioral scientists interested in following the temporal sequelae of brain lesions with respect to increasing deficits and tot potential recovery mechanisms and neuronal plasticity. Finally, the proposed work will provide prognostic indices for those involved in providing patient rehabilitation services.

描述：拟议研究的主要目标是提供 需要关于颞叶的长期行为影响的信息 手术颞叶手术是最常进行的癫痫 外科手术这种手术的临床结果已经被 人印象深刻.然而，关于手术后行为后遗症的报道 有限，大多数研究在手术后第一年内进行。 虽然情绪和社会领域的改善已报告， 对治疗成功的患者进行短期随访， 行为后遗症并不总是积极的。无长期纵向 对颞叶手术的行为影响的研究是可用的。 该研究满足了系统调查 颞叶手术对医疗、社会和情感的长期影响 功能研究是基于对个人的纵向跟踪， 他们患有难治性癫痫， 在一所大型大学外科诊断中心进行心理评估。 以下三组患者： 标准化颞叶切除术，接受额外- 颞叶切除术和对照组的患者， 相同的术前评价，但不符合/或被拒绝 手术拟议的研究将确定 颞叶手术后1年和5年的变化相似 手术后9年以上的患者。的相互关系 情绪、认知和社会变化以及选定的临床指标 将被确定。最后，当这些患者接近正常年龄时， 衰老过程开始，潜在的后期行为变化将 鉴定这些变化将与缉获量的影响有关， 其他相关的治疗效果。这些发现将是非常宝贵的， 临床医生和一般保健提供者参与临床 癫痫的治疗方法有哪些？这些信息将 对于那些有兴趣研究 大脑损伤的暂时性后遗症， 以及潜在的恢复机制和神经元可塑性。最后， 建议的工作将为那些参与 提供病人康复服务。