LONG TERM EFFECTS OF TEMPORAL LOBE EPILEPSY

颞叶癫痫的长期影响

• 批准号: 2891857
• 负责人: H REBECCA RAUSCH
• 金额: $ 19.74万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-02 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2891857
• 关键词: aging; behavior; behavioral /social science research tag; clinical research; cognition; emotions; functional ability; human subject; human therapy evaluation; longitudinal human study; neuropsychological tests; neurosurgery; partial seizure; postoperative complications; postoperative state; social adjustment

DESCRIPTION: The major goal of the proposed research is to provide much needed information as to the long-term behavior effects of temporal-lobe surgery. Temporal lobe surgery is the most frequently performed epilepsy surgery procedure. The clinical results of such surgery have been impressive. However, reports of the behavioral sequelae of surgery are limited, with most studies performed within the first year after surgery. While improvement in emotional and social domains have been reported in the short-term follow-up in the successfully-treated patients, the behavioral sequelae is not always positive. No long-term longitudinal studies of the behavioral effects of temporal lobe surgery are available. The proposed research meets the need for a systematic investigation of the long-term impact of temporal lobe surgery on medical, social and emotional functioning. Studies are based on the longitudinal follow-up of persons who had intractable epilepsy and who underwent a standardized clinical and psychological evaluation in a large university surgical diagnostic center. Three groups of patients are followed: Patients who underwent a standardized temporal lobe resection, patients who underwent an extra- temporal lobe resection and a comparison group of patients who underwent the same pre-surgical evaluation but did not qualify for/or refused surgery. The proposed studies will determine the extent to which the changes seen one year and 5 years after temporal lobe surgery are similar to those seen greater than 9 years post surgery. The interrelationship of emotional, cognitive, and social changes and selected clinical measures will be determined. Finally, as these patients approach ages when normal aging process begin, potential late changes in behavior will be identified. These changes will be related to the impact of seizures and other related treatment effects. These findings will be invaluable to clinicians and general health-care providers involved in clinical decisions on the surgical treatment of epilepsy. Such information will also be important for neurobehavioral scientists interested in following the temporal sequelae of brain lesions with respect to increasing deficits and tot potential recovery mechanisms and neuronal plasticity. Finally, the proposed work will provide prognostic indices for those involved in providing patient rehabilitation services.

描述：拟议研究的主要目标是提供更多 关于颞叶长期行为影响的所需信息 做手术。颞叶手术是最常见的癫痫 手术程序。这种手术的临床结果是 令人印象深刻。然而，关于手术的行为后遗症的报道是 有限，大多数研究是在手术后第一年内进行的。 虽然在情感和社交领域的改善已经在 成功治疗的患者的短期随访， 行为后遗症并不总是积极的。没有长期的纵向 关于颞叶手术的行为影响的研究是可用的。 拟议的研究满足了对 颞叶手术对医学、社会和情绪的长期影响 功能正常。研究是基于对人的纵向跟踪 他患有顽固性癫痫，并接受了标准化的临床和 某大型高校外科诊断中心的心理测评。 对三组患者进行了跟踪：接受了 标准化的颞叶切除术，患者接受了额外的 颞叶切除和接受手术的对照组患者 同样的手术前评估，但不符合/或拒绝 做手术。拟议的研究将确定在多大程度上 颞叶手术后一年和五年的变化相似 对于术后超过9年的患者。的相互关系 情绪、认知和社会变化与选定的临床措施 将会被确定。最后，当这些患者接近正常年龄时 老龄化过程开始，潜在的后期行为变化将是 确认身份。这些变化将与癫痫发作的影响和 其他相关治疗效果。这些发现将对 参与临床工作的临床医生和一般医疗服务提供者 关于癫痫外科治疗的决定。这样的信息将 对于对以下内容感兴趣的神经行为科学家也很重要 脑部损伤与功能缺陷增加相关的暂时性后遗症 以及TOT电位恢复机制和神经元可塑性。最后， 拟议的工作将为那些参与其中的人提供预后指数 提供病人康复服务。