LONG-TERM EFFECTS OF TEMPORAL LOBE SURGERY

颞叶手术的长期影响

• 批准号: 2269224
• 负责人: H REBECCA RAUSCH
• 金额: $ 21.57万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-02 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2269224
• 关键词: behavior test; cognition disorders; electroencephalography; functional ability; human subject; human therapy evaluation; longitudinal human study; mental disorder diagnosis; neurosurgery; partial seizure; postoperative complications; postoperative state; preoperative state; prognosis; temporal lobe /cortex disorder

The proposed research is designed to provide an understanding of long- term behavioral effects of temporal lobectomy surgery for intractable- epilepsy. the occurrence of intractable-seizures is well-known to impact negatively upon several quality of life domains, including cognition, emotion and social function. Surgical intervention is now an accepted treatment for epilepsy which is refractory to pharmacologic therapy, and temporal lobectomy is the most frequently performed epilepsy surgery. The clinical results of such surgery on seizure control have been impressive. However, reports on the behavioral sequelae of surgery for epilepsy have been limited, with most studies aimed at only the first year after surgery. No comprehensive, long-term follow-up of the behavioral effects of temporal lobe surgery are available. Hence, we plan to undertake a systematic re-assessment of patients who had undergone temporal lobe surgery for intractable-epilepsy at one-, five-, ten-, and fifteen-years ago. These patients had all participated in a standardized clinical and psychological research protocol at our institution and have available the results of routine diagnostic evaluations done prior to surgery. Additional groups of epilepsy patients who (a) participated in pre-surgical evaluations but did not quality for/or refused surgery or (b) had extra-temporal lobe resections will also be followed for comparison. The proposed work will provide information regarding the long-term cognitive, emotional, and social effects of temporal lobectomy surgery as well as aiding in identification of those critical factors affecting clinical outcome. Such results will be invaluable to clinicians, neurobehaviorists, and general healthcare- providers involved in patient management decisions regarding surgical treatment for epilepsy. Moreover, the proposed data bank will provide new direction in developing more effective patient-rehabilitation services after surgery and may contribute to our further understanding of the sequelae and plasticity of human behaviors associated with specific brain lesions.

这项研究旨在提供对长期- 颞叶切除术对难治性- 癫痫 众所周知，难治性癫痫发作会影响 对几个生活质量领域产生负面影响，包括认知， 情感和社会功能。 手术治疗现在是一种公认的 药物治疗难治性癫痫的治疗，以及 颞叶切除术是最常进行的癫痫手术。 这种手术对癫痫控制的临床效果已经被证实。 人印象深刻. 然而，关于手术后行为后遗症的报道， 癫痫已经被限制，大多数研究只针对第一个 手术后一年。 没有全面、长期的后续行动， 颞叶手术对行为的影响 所以我们 计划对那些患有 在一岁五岁时接受了颞叶手术治疗顽固性癫痫 10年和15年前。 这些病人都参加了一个 标准化的临床和心理研究协议， 机构，并提供常规诊断结果 手术前进行评估。 癫痫的症状 患者（a）参加了术前评估，但未 质量不合格/或拒绝手术或（B）接受了颞叶外切除术 也将进行比较。 拟议的工作将提供 关于长期认知，情感和社会的信息 颞叶切除术的效果以及帮助识别 影响临床结果的关键因素。 这样的结果将 对临床医生、神经行为学家和一般医疗保健来说是无价的- 参与手术相关患者管理决策的提供者 癫痫的治疗方法 此外，拟议的数据库将提供 发展更有效病人康复的新方向 手术后的服务，并可能有助于我们进一步了解 人类行为的后遗症和可塑性， 特定的脑部病变