COGNITIVE & BRAIN CHANGES AFTER ADJUVANT THERAPY IN BREAST CANCER

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该研究探讨了乳腺癌辅助治疗后患者的认知和大脑改变。众所周知，许多女性在乳腺癌化疗期间会经历短暂的认知变化。我们的研究集中在标准的全身化疗结束后继续存在的残余认知变化。我们认为，通过核磁共振识别的大脑变化与这些长期认知变化有关。该研究为当前乳腺癌辅助治疗的长期效果提供了急需的信息。这些研究的结果可能会为这些患者带来新的治疗干预措施，从而影响他们的生活质量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study addresses cognitive and brain alterations in patients after adjuvant therapy for breast cancer. It is well known that many women experience transient cognitive changes during chemotherapy for breast cancer. Our research has focused on the residual cognitive changes that continue after standard systemic chemotherapy has ended. We propose that brain alterations as identified by MRI are associated with these long-term cognitive changes. The study provides much needed information on the long-term effects of current adjuvant treatment for breast cancer. The results from these studies may lead to new treatment interventions for these patients and thus affect their quality of life.