DNA VACCINES--IMMUNE RESPONSES AND ANTIGEN PROCESSING

DNA 疫苗——免疫反应和抗原加工

• 批准号: 2765853
• 负责人: Margaret A. Liu
• 金额: $ 0.1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-23 至 2000-04-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2765853
• 关键词: antigen presentation; immunoregulation; meeting /conference /symposium; travel; vaccine development; vector vaccine

DNA vaccines contain genes encoding antigens, which upon administration to the host are expressed in situ leading to immune responses directed against the protein. This novel technology has proven to be a versatile and effective means of generating protective immunity including MHC Class I-restricted cytotoxic T lymphocytes (CTL), MHC Class II- restricted helper T cells, and antibodies. Recent advances in the field have been made in the areas of mechanisms by which DNA vaccines induce CTL responses, means to augment and manipulate specific types of responses, ways to more effectively deliver DNA vaccines, targeting antigens to various subcellular locations to alter the type of immune response, and adjuvanticity of the bacterial DNA sequences themselves. This meeting will bring together scientists who are using this powerful tool to further understand both how to direct antigen processing in order to generate or augment particular immune responses and how the form of antigen (including the presence of DNA sequences per se) affects immunogenicity. The meeting should also contribute significantly to the development of novel vaccine strategies.

DNA疫苗含有编码抗原的基因， 在原位表达，导致免疫应答针对 对抗蛋白质。 这项新技术已被证明是一种多功能的 和产生保护性免疫的有效手段，包括MHC I类限制性细胞毒性T淋巴细胞（CTL），MHC II类- 限制性辅助T细胞和抗体。 领域的最新进展 已经在DNA疫苗诱导的机制领域取得了进展， CTL应答，增加和操纵特定类型的CTL的手段， 如何更有效地提供DNA疫苗， 抗原的各种亚细胞位置，以改变免疫类型， 反应和细菌DNA序列本身的佐剂性。 这次会议将汇集科学家谁是使用这种强大的 工具，以进一步了解如何指导抗原加工， 以产生或增强特定的免疫反应，以及 抗原的形式（包括DNA序列本身的存在）影响 免疫原性 会议还应大力促进 开发新的疫苗策略。