BASIC SCIENCE TRAINING IN ENDOCRINOLOGY & IMMUNOLOGY

内分泌学基础科学培训

• 批准号: 3085067
• 负责人: Margaret A. Liu
• 金额: $ 7.71万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1990-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3085067
• 关键词: T lymphocyte; biology; chemistry; endocrinology; genetic manipulation; health care personnel education; health science research; immunology; mathematics; parathyroid hormones; physicians; university

This proposal is designed to provide broad and thorough scientific training not available in traditional post-graduate research progrmas for physicians entering academic medicine. This proposal combines the scholarly excellence of graduate coursework and research at the Massachusetts Institute of Technology with the strengths of the superb clinical environment and basic medical research of the Massachusetts General Hospital. The sponsor, Dr. Herman N. Eisen, is an accomplished physician scientist who has had outstanding experience training young investigators. Two phases are envisioned, followed or perhaps split by a clinical fellowship in endocrinology. Phase I involves graduate level coursework in the departments of Biology, Chemistry and Mathematics at MIT. Research in Dr. Eisen's laboratory will center around the study of the antigen receptor of the T lymphocyte. The techniques being used in this laboratory to examine the receptor include serological approaches as well as recombinant DNA studies elucidating the structure of the Yield subunit. Learning to use a number of different tools and procedures from the fields of immunology and molecular genetics in one of the country's foremost laboratories will provide excellent training for future research with membrane receptors. More importantly, Dr. Eisen's sponsorship and laboratory, and the MIT academic offerings ensure a rigorous environment for the process of becoming a discerning competent scientist. Progress during Phase I will be evaluated by a committee of basic scientists with a commitment to medical education and the areas of research noted above. During Phase II, the approaches learned in Phase I will be applied to studying receptors of the endocrine system under both physiological and pathological conditions. An example of a possible Phase II project is the study of parathyroid hormone receptors on lymphocytes. The possible functions and regulation of these receptors raise many important issues of direct clinical relevance. A definite Phase II sponsor will be chosen in the future; such work would proceed under the general guidance of Drs. Henry Kronenberg, Gino Serge, and John Potts, all members of the Endocrine Unit at MGH

这项建议旨在提供广泛和全面的科学培训 在传统的医生研究生研究计划中不可用 进入学术医学。 该提案结合了学术 卓越的研究生课程和研究在马萨诸塞州 技术学院凭借精湛的临床实力 马萨诸塞州环境与基础医学研究 医院 申办者赫尔曼N.是一位有成就的内科医生 在培训年轻研究人员方面有着杰出经验的科学家。 设想了两个阶段，随后或可能分为临床 内分泌学奖学金 第一阶段涉及研究生水平的课程， 麻省理工学院的生物、化学和数学系。 研究 博士埃里森的实验室将以抗原受体的研究为中心 的T淋巴细胞。 这个实验室使用的技术 检测受体包括血清学方法以及重组 DNA研究阐明了产量亚基的结构。 学习 使用来自以下领域的许多不同工具和程序： 免疫学和分子遗传学在这个国家最重要的 实验室将为未来的研究提供良好的培训， 膜受体 更重要的是， 实验室和麻省理工学院的学术课程确保了严格的环境 成为一个有洞察力的合格科学家的过程。 进展 在第一阶段，将由一个基础科学家委员会进行评估， 致力于医学教育和上述研究领域。 在第二阶段，第一阶段学到的方法将应用于 研究生理和生理条件下内分泌系统的受体， 病理条件。 可能的第二阶段项目的一个例子是 淋巴细胞上甲状旁腺激素受体的研究。 可能的 这些受体的功能和调节提出了许多重要的问题， 直接临床相关性。 将选择一个明确的II期申办者， 未来;这些工作将在博士的一般指导下进行。 亨利克罗嫩伯格，吉诺塞尔日，和约翰波茨，所有的成员内分泌 MGH单位

项目成果

Effect of recombinant soluble CD4 on human peripheral blood lymphocyte responses in vitro.

重组可溶性CD4对体外人外周血淋巴细胞反应的影响。

• DOI: 10.1172/jci113842
• 发表时间: 1988
• 期刊: The Journal of clinical investigation
• 作者: Liu,MA;Liu,T
• 通讯作者: Liu,T