BASIC SCIENCE TRAINING IN ENDOCRINOLOGY & IMMUNOLOGY

该提案旨在提供广泛而彻底的科学培训 传统的医生研究生研究项目不提供 进入学术医学。 该提案结合了学术界 马萨诸塞州研究生课程和研究的卓越性 技术研究所具有精湛的临床优势 马萨诸塞州综合医院的环境和基础医学研究 医院。 发起人 Herman N. Eisen 博士是一位卓有成就的医生 在培训年轻研究人员方面拥有杰出经验的科学家。 设想两个阶段，随后或可能分开临床 内分泌学研究金。 第一阶段涉及研究生水平的课程作业 麻省理工学院的生物系、化学系和数学系。 研究于 艾森博士的实验室将围绕抗原受体的研究 T 淋巴细胞。 该实验室使用的技术 检查受体包括血清学方法以及重组方法 DNA 研究阐明了产量亚基的结构。 学习 使用以下领域的许多不同的工具和程序 免疫学和分子遗传学是该国最重要的学科之一 实验室将为未来的研究提供优秀的培训 膜受体。 更重要的是，艾森博士的赞助和 实验室和麻省理工学院的学术课程确保了严格的环境 成为一名有洞察力、有能力的科学家的过程。 进展 在第一阶段期间，将由一个由基础科学家组成的委员会进行评估 对医学教育和上述研究领域的承诺。 在第二阶段，第一阶段学到的方法将应用于 研究生理和环境下内分泌系统的受体 病理状况。 可能的第二阶段项目的一个例子是 淋巴细胞上甲状旁腺激素受体的研究。 可能的 这些受体的功能和调节引发了许多重要问题 直接的临床相关性。 确定的第二阶段赞助商将在 未来；此类工作将在博士的总体指导下进行。 亨利·克罗嫩伯格 (Henry Kronenberg)、吉诺·塞尔吉 (Gino Serge) 和约翰·波茨 (John Potts)，内分泌科的所有成员 麻省总医院单位

This proposal is designed to provide broad and thorough scientific training not available in traditional post-graduate research progrmas for physicians entering academic medicine. This proposal combines the scholarly excellence of graduate coursework and research at the Massachusetts Institute of Technology with the strengths of the superb clinical environment and basic medical research of the Massachusetts General Hospital. The sponsor, Dr. Herman N. Eisen, is an accomplished physician scientist who has had outstanding experience training young investigators. Two phases are envisioned, followed or perhaps split by a clinical fellowship in endocrinology. Phase I involves graduate level coursework in the departments of Biology, Chemistry and Mathematics at MIT. Research in Dr. Eisen's laboratory will center around the study of the antigen receptor of the T lymphocyte. The techniques being used in this laboratory to examine the receptor include serological approaches as well as recombinant DNA studies elucidating the structure of the Yield subunit. Learning to use a number of different tools and procedures from the fields of immunology and molecular genetics in one of the country's foremost laboratories will provide excellent training for future research with membrane receptors. More importantly, Dr. Eisen's sponsorship and laboratory, and the MIT academic offerings ensure a rigorous environment for the process of becoming a discerning competent scientist. Progress during Phase I will be evaluated by a committee of basic scientists with a commitment to medical education and the areas of research noted above. During Phase II, the approaches learned in Phase I will be applied to studying receptors of the endocrine system under both physiological and pathological conditions. An example of a possible Phase II project is the study of parathyroid hormone receptors on lymphocytes. The possible functions and regulation of these receptors raise many important issues of direct clinical relevance. A definite Phase II sponsor will be chosen in the future; such work would proceed under the general guidance of Drs. Henry Kronenberg, Gino Serge, and John Potts, all members of the Endocrine Unit at MGH