Conference on Gene-Based Vaccines

基于基因的疫苗（基于质粒和载体）被认为是最有前途的方法，用于制备针对许多传染病和癌症的预防性和治疗性疫苗。这些疫苗可以诱导细胞溶解性T细胞反应，被认为是许多病毒和寄生虫疾病和癌症的关键，比基于蛋白质或杀死生物体的疫苗更有效，但没有减毒病毒必须具有的潜在风险。此外，它们在生产全球范围所需疫苗方面可能具有其他一些技术优势。它们也被用作研究基本免疫学问题的工具，如抗原加工和呈递的机制，先天性和适应性免疫系统的相互作用，以及体液与细胞免疫的作用。然而，为了充分利用这些疫苗的潜力，需要解决一些基本问题，包括通过理解DNA摄取和抗原呈递的机制来提高疫苗的效力，并确定如何利用DNA本身的意外免疫刺激作用，以及理解不同基因疫苗联合使用的提高效力的机制。本次会议将提供一个独特的论坛，吸引并旨在促进研究各个阶段的最大多学科互动，即从基础细胞生物学和免疫学到传染病和临床试验，这些临床试验更侧重于这些疫苗临床开发的监管方面，或应用，这次会议将提供一个机会，使来自各个领域的科学家聚集在一起（微生物学、病毒学、细胞生物学、疫苗学、基因治疗、肿瘤学、感染性疾病、聚合物化学）以解决所涉及的基本细胞机制，然而在疫苗和治疗的更大背景下。

Gene-based vaccines (both plasmid- and vector-based) are considered a most promising approach for making both prophylactic and therapeutic vaccines against a number of infectious diseases and cancer. These vaccines can induce the cytolytic T cell responses thought to be critical for many viral and parasitic diseases and cancer more effectively than protein-based or killed-organism vaccines, yet do not have the potential risk that attenuated viruses must have. In addition, they may have a number of other technological advantages for vaccines needed on a global scale. They have likewise been utilized as tools to study fundamental immunological questions such as mechanisms of antigen processing and presentation, the interactions of the innate and adaptive immune systems, and the role of humoral vs. cellular immunity. However, a number of fundamental issues need to be addressed in order to fully exploit the potential of these vaccines, including increasing the potency of the vaccines by understanding the mechanisms of DNA uptake and antigen presentation, and determining how to harness the unexpected immunostimulatory effects of DNA itself, and understanding the mechanisms for the increased efficacy of the combined use of different gene-based vaccines. This meeting will provide a unique forum that attracts and is designed to promote the maximal multi-disciplinary interactions at various stages of research, that is, ranging from fundamental cell biology and immunology, to infectious disease and clinical trials that have been more focused on regulatory aspects of the clinical development of these vaccines, or upon the applications, this meeting will provide the opportunity to bring together scientists from a variety of fields (microbiology, virology, cell biology, vaccinology, gene therapy, oncology, infectious diseases, polymer chemistry) to address the fundamental cellular mechanisms involved, yet within the greater context of the vaccines and therapeutics.