Conference on Gene-Based Vaccines

基因疫苗会议

• 批准号: 6446599
• 负责人: Margaret A. Liu
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6446599
• 关键词: immunology; meeting /conference /symposium; neoplasm /cancer vaccine; travel; vaccine development; vector vaccine

Gene-based vaccines (both plasmid- and vector-based) are considered a most promising approach for making both prophylactic and therapeutic vaccines against a number of infectious diseases and cancer. These vaccines can induce the cytolytic T cell responses thought to be critical for many viral and parasitic diseases and cancer more effectively than protein-based or killed-organism vaccines, yet do not have the potential risk that attenuated viruses must have. In addition, they may have a number of other technological advantages for vaccines needed on a global scale. They have likewise been utilized as tools to study fundamental immunological questions such as mechanisms of antigen processing and presentation, the interactions of the innate and adaptive immune systems, and the role of humoral vs. cellular immunity. However, a number of fundamental issues need to be addressed in order to fully exploit the potential of these vaccines, including increasing the potency of the vaccines by understanding the mechanisms of DNA uptake and antigen presentation, and determining how to harness the unexpected immunostimulatory effects of DNA itself, and understanding the mechanisms for the increased efficacy of the combined use of different gene-based vaccines. This meeting will provide a unique forum that attracts and is designed to promote the maximal multi-disciplinary interactions at various stages of research, that is, ranging from fundamental cell biology and immunology, to infectious disease and clinical trials that have been more focused on regulatory aspects of the clinical development of these vaccines, or upon the applications, this meeting will provide the opportunity to bring together scientists from a variety of fields (microbiology, virology, cell biology, vaccinology, gene therapy, oncology, infectious diseases, polymer chemistry) to address the fundamental cellular mechanisms involved, yet within the greater context of the vaccines and therapeutics.

基于基因的疫苗（基于质粒和基于载体）被认为是制造针对多种传染病和癌症的预防性和治疗性疫苗的最有前途的方法。这些疫苗可以比基于蛋白质或灭活生物体的疫苗更有效地诱导溶细胞 T 细胞反应，这种反应被认为对许多病毒和寄生虫疾病以及癌症至关重要，但不存在减毒病毒必须具有的潜在风险。此外，他们可能还拥有全球范围内所需疫苗的许多其他技术优势。它们同样被用作研究基本免疫学问题的工具，例如抗原加工和呈递机制、先天免疫系统和适应性免疫系统的相互作用以及体液免疫与细胞免疫的作用。然而，为了充分发挥这些疫苗的潜力，需要解决一些基本问题，包括通过了解 DNA 摄取和抗原呈递机制来提高疫苗的效力，确定如何利用 DNA 本身意想不到的免疫刺激作用，以及了解联合使用不同基因疫苗提高功效的机制。这次会议将提供一个独特的论坛，吸引并旨在促进各个研究阶段的最大程度的多学科互动，即从基础细胞生物学和免疫学，到传染病和临床试验，这些阶段更加关注这些疫苗临床开发的监管方面，或者在应用方面，这次会议将提供将来自各个领域（微生物学、病毒学、细胞学）的科学家聚集在一起的机会。 生物学、疫苗学、基因治疗、肿瘤学、传染病、高分子化学），以解决所涉及的基本细胞机制，但在疫苗和治疗的更大范围内。