Conference on Gene-Based Vaccines

基于基因的疫苗(包括基于质粒和载体的疫苗)被认为是制造预防和治疗多种传染病和癌症疫苗的最有前途的方法。这些疫苗可以比基于蛋白质或杀死生物的疫苗更有效地诱导被认为对许多病毒、寄生虫病和癌症至关重要的细胞溶解T细胞反应，但没有减毒病毒必须具有的潜在风险。此外，在全球范围内所需的疫苗方面，它们可能还有其他一些技术优势。它们同样被用作研究基本免疫学问题的工具，如抗原处理和提呈的机制，先天性和获得性免疫系统的相互作用，以及体液免疫与细胞免疫的作用。然而，为了充分挖掘这些疫苗的潜力，需要解决一些基本问题，包括通过了解DNA摄取和抗原呈递的机制来提高疫苗的效力，确定如何利用DNA本身的意外免疫刺激效应，以及了解不同基因疫苗联合使用提高效力的机制。这次会议将提供一个独特的论坛，吸引并旨在促进研究不同阶段的最大限度的多学科互动，即从基础细胞生物学和免疫学，到传染病和临床试验，这些研究更侧重于这些疫苗临床开发的监管方面，或关于这些疫苗的应用，这次会议将提供机会，将来自不同领域(微生物学、病毒学、细胞生物学、疫苗学、基因疗法、肿瘤学、传染病、聚合物化学)的科学家聚集在一起，讨论所涉及的基本细胞机制，但在疫苗和治疗学的更大范围内。

Gene-based vaccines (both plasmid- and vector-based) are considered a most promising approach for making both prophylactic and therapeutic vaccines against a number of infectious diseases and cancer. These vaccines can induce the cytolytic T cell responses thought to be critical for many viral and parasitic diseases and cancer more effectively than protein-based or killed-organism vaccines, yet do not have the potential risk that attenuated viruses must have. In addition, they may have a number of other technological advantages for vaccines needed on a global scale. They have likewise been utilized as tools to study fundamental immunological questions such as mechanisms of antigen processing and presentation, the interactions of the innate and adaptive immune systems, and the role of humoral vs. cellular immunity. However, a number of fundamental issues need to be addressed in order to fully exploit the potential of these vaccines, including increasing the potency of the vaccines by understanding the mechanisms of DNA uptake and antigen presentation, and determining how to harness the unexpected immunostimulatory effects of DNA itself, and understanding the mechanisms for the increased efficacy of the combined use of different gene-based vaccines. This meeting will provide a unique forum that attracts and is designed to promote the maximal multi-disciplinary interactions at various stages of research, that is, ranging from fundamental cell biology and immunology, to infectious disease and clinical trials that have been more focused on regulatory aspects of the clinical development of these vaccines, or upon the applications, this meeting will provide the opportunity to bring together scientists from a variety of fields (microbiology, virology, cell biology, vaccinology, gene therapy, oncology, infectious diseases, polymer chemistry) to address the fundamental cellular mechanisms involved, yet within the greater context of the vaccines and therapeutics.