IMMUNE DISREGULATION IN MALARIA AND CONCOMMITANT MEASLES

描述 初步研究：2005年，村庄的疟疾寄生虫率为57%。 儿童和41%的成年人。 记录在案的病例增加了30%， 在1995年到1996年之间。 1995年5月爆发麻疹， mortality. 死亡率通常与继发性细菌感染有关。 感染，因此怀疑免疫抑制。 Quakyi博士提出， 疟疾引起的TH 1反应和 麻疹可能导致无反应性。 ELISA法检测的抗疟抗体相似 然而，在麻疹和非麻疹人群中， 在疟疾寄生虫血症患者中， 寄生虫阴性。 这些发现对地方性流行病具有重要的公共卫生指示意义。 麻疹疫苗接种如果在接种期间进行， 因此，在寄生虫血症高发季节，应在低寄生虫血症季节给予 疟疾季节 在雅温得医院接种麻疹疫苗的儿童将被邀请 并定期抽血，以确定 麻疹和疟疾抗体的水平和持续时间， 通过细胞因子和同种型测定对TH 1/TH 2应答进行分类，以及 PBMC对麻疹和疟疾抗原的增殖反应。 这 工作将有望导致足够的数据形式的基础上，一个区域办事处1 应用程序.

DESCRIPTION Preliminary studies: Malarial parasite rates in villages were 57% in children and 41% in adults. A 30% increase in recorded cases was seen between 1995 and 1996. In May 1995 there was a measles outbreak with 29% mortality. Mortality was often associated with secondary bacterial infections, thus immunosuppression was suspected. Dr. Quakyi proposed that the TH1 responses elicited by malaria and the TH2 responses elicited by measles may result in anergy. Malarial AMA antibodies were similar by ELISA in both measles and non-measles groups, however, lower measles antibodies were observed for people with malaria parasitemia, than people who were parasite negative. These findings have an important public health indication for the endemic area Measles vaccinations will probably be less effective if given during the high parasitemia season, therefore, they should be given at the low malaria season. Children being vaccinated for measles at Yaounde hospital will be invited to return and have their blood drawn at regular intervals in order to determine the levels and duration of measles and malarial antibodies, the categorization of TH1/TH2 responses via cytokine and isotyping assays, and the proliferative responses of PBMC to measles and malarial antigens. This work will hopefully lead to enough data form the basis for a RO1 application.