Intravital Microscopy Biomedical Resource Core

项目摘要/摘要(活体显微生物医学资源核心) 自2002年作为NIDDK资助的P50中心成立以来，印第安纳奥布莱恩中心的使命是 对于先进的肾脏显微镜检查已经为肾脏研究人员提供了有效的途径来获得先进的 显微镜的形式。在过去20年的持续资助中，伊利诺伊州奥布莱恩中心开创了 已应用的多光子活体显微技术新方法的发展和推广 与来自世界各地的研究人员合作研究肾脏生理学和病理生理学。这个 活体显微生物医学资源核心将为肾脏研究社区提供访问 IU O‘Brien中心的专业知识和资源，以支持大鼠和小鼠的活体显微镜研究 肾脏。活体显微生物医学资源核心的具体目标是：(1)提供肾脏 具有专家活体显微镜服务的研究社区，以支持生理学的定量研究 以及(2)提供活体显微镜和成像方法方面的培训 这样，只要有可能，研究人员就能够进行活体显微镜研究 在他们自己的机构里独立工作。

Project Summary/Abstract (Intravital Microscopy Biomedical Resource Core) From its inception as an NIDDK-funded P50 Center in 2002, the mission of the Indiana O’Brien Center for Advanced Renal Microscopy has been to provide renal researchers with effective access to advanced forms of microscopy. Over the past 20 years of continuous funding, the IU O’Brien Center has pioneered the development and dissemination of novel methods of multiphoton intravital microscopy that have been applied in collaborative studies of renal physiology and pathophysiology with investigators from around the world. The Intravital Microscopy Biomedical Resource Core will provide the renal research community with access to the expertise and resources of the IU O’Brien Center to support intravital microscopy studies of the rat and mouse kidney. The specific aims of the Intravital Microscopy Biomedical Resource Core are to (1) provide the renal research community with expert intravital microscopy services to support quantitative studies of the physiology and cell biology of mice and rats and (2) provide training in methods of intravital microscopy and image analysis so that, wherever possible, investigators are capable of conducting intravital microscopy studies independently at their home institutions.