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CARBOHYDRATE-BASED TUMOR VACCINES

CARBOHYDRATE-BASED TUMOR VACCINES
基于碳水化合物的肿瘤疫苗
批准号：
2733247
负责人：
KENNETH O LLOYD
金额：
$22.16万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
项目状态：
已结题
起止时间：
1996-09-01 至 2001-06-30
来源：
https://reporter.nih.gov/project-details/2733247
关键词：
chemical synthesis clinical research drug design /synthesis /production drug screening /evaluation female human subject immunoconjugates laboratory mouse laboratory rat neoplasm /cancer immunotherapy neoplasm /cancer vaccine oligosaccharides ovary neoplasms synthetic tumor antigen vaccine development

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中文摘要
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英文摘要
DESCRIPTION (Adapted from the Applicant's Abstract): In this application the investigator proposes to examine the use of Ley and globo H carbohydrate antigens as vaccines for the possible therapy of ovarian epithelial cancer. The aims are: 1) to synthesize Ley and globo H oligosaccaharides and to couple them to carrier proteins. 2) to pursue preclinical immunogenicity studies on these antigens to determine the best conjugates and most effective adjuvant to induce an antibody response reacting with tumor cells and 3) to possibly extend these studies to a clinical trial in high risk ovarian cancer patients to determine if an antibody response can be obtained in humans.
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会议论文
IMMUNOLOGICAL, BIOCHEMICAL, AND MOLECULAR STUDIES ON EPITHELIAL OVARIAN CANCER
CORE--CELL CULTURE, ANTIBODY, AND BIOCHEMISTRY CORE
IMMUNOLOGICAL, BIOCHEMICAL, AND MOLECULAR STUDIES ON EPITHELIAL OVARIAN CANCER
CORE--CELL CULTURE, ANTIBODY, AND BIOCHEMISTRY CORE
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