CARBOHYDRATE-BASED TUMOR VACCINES

基于碳水化合物的肿瘤疫苗

• 批准号: 2733247
• 负责人: KENNETH O LLOYD
• 金额: $ 22.16万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2733247
• 关键词: chemical synthesis; clinical research; drug design /synthesis /production; drug screening /evaluation; female; human subject; immunoconjugates; laboratory mouse; laboratory rat; neoplasm /cancer immunotherapy; neoplasm /cancer vaccine; oligosaccharides; ovary neoplasms; synthetic tumor antigen; vaccine development

DESCRIPTION (Adapted from the Applicant's Abstract): In this application the investigator proposes to examine the use of Ley and globo H carbohydrate antigens as vaccines for the possible therapy of ovarian epithelial cancer. The aims are: 1) to synthesize Ley and globo H oligosaccaharides and to couple them to carrier proteins. 2) to pursue preclinical immunogenicity studies on these antigens to determine the best conjugates and most effective adjuvant to induce an antibody response reacting with tumor cells and 3) to possibly extend these studies to a clinical trial in high risk ovarian cancer patients to determine if an antibody response can be obtained in humans.

描述（改编自申请人的摘要）：在本申请中， 研究者建议检查Ley和globo H碳水化合物的使用 抗原作为疫苗用于卵巢上皮癌的可能治疗。 目的是：1）合成Ley和globo H低聚糖， 将它们与载体蛋白结合。 2)研究临床前免疫原性 对这些抗原的研究，以确定最好的缀合物和最 诱导与肿瘤细胞反应的抗体应答的有效佐剂 和3）可能将这些研究扩展到高风险的临床试验 卵巢癌患者，以确定是否可以获得抗体反应， 在人类身上。