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CARBOHYDRATE-BASED TUMOR VACCINES

CARBOHYDRATE-BASED TUMOR VACCINES
基于碳水化合物的肿瘤疫苗
批准号：
6173066
负责人：
KENNETH O LLOYD
金额：
$23.41万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
项目状态：
已结题
起止时间：
1996-09-01 至 2002-06-30
来源：
https://reporter.nih.gov/project-details/6173066
关键词：
chemical synthesis clinical research drug design /synthesis /production drug screening /evaluation female human subject immunoconjugates laboratory mouse laboratory rat neoplasm /cancer immunotherapy neoplasm /cancer vaccine oligosaccharides ovary neoplasms synthetic tumor antigen vaccine development

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中文摘要
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英文摘要
DESCRIPTION (Adapted from the Applicant's Abstract): In this application the investigator proposes to examine the use of Ley and globo H carbohydrate antigens as vaccines for the possible therapy of ovarian epithelial cancer. The aims are: 1) to synthesize Ley and globo H oligosaccaharides and to couple them to carrier proteins. 2) to pursue preclinical immunogenicity studies on these antigens to determine the best conjugates and most effective adjuvant to induce an antibody response reacting with tumor cells and 3) to possibly extend these studies to a clinical trial in high risk ovarian cancer patients to determine if an antibody response can be obtained in humans.
期刊论文(4)
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会议论文
Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens.
来自接受 Globo H 匙孔血蓝蛋白疫苗免疫的患者的多克隆抗体：通过使用完全合成的固定化肿瘤抗原来分离、定量和表征免疫反应。
DOI： 10.1073/pnas.97.6.2719
发表时间： 2000
期刊： Proceedings of the National Academy of Sciences of the United States of America
影响因子： 11.1
作者： [Wang,ZG, Williams,LJ, Zhang,XF, Zatorski,A, Kudryashov,V, Ragupathi,G, Spassova,M, Bornmann,W, Slovin,SF, Scher,HI, Livingston,PO, Lloyd,KO, Danishefsky,SJ]
通讯作者： Danishefsky,SJ
IMMUNOLOGICAL, BIOCHEMICAL, AND MOLECULAR STUDIES ON EPITHELIAL OVARIAN CANCER
CORE--CELL CULTURE, ANTIBODY, AND BIOCHEMISTRY CORE
IMMUNOLOGICAL, BIOCHEMICAL, AND MOLECULAR STUDIES ON EPITHELIAL OVARIAN CANCER
CORE--CELL CULTURE, ANTIBODY, AND BIOCHEMISTRY CORE
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